EHT1864
- CAS No.
- 754240-09-0
- Chemical Name:
- EHT1864
- Synonyms
- CS-1343;CS-1239;EHT 1864;EHT-1864 2HCl;EHT 1864, >=98%;EHT1864 USP/EP/BP;EHT-1864;EHT-1864;EHT-1864Dihydrochloride;5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride;2-(morpholin-4-ylmethyl)-5-[5-[7-(trifluoromethyl)quinolin-4-yl]sulfanylpentoxy]pyran-4-one,dihydrochloride
- CBNumber:
- CB12095478
- Molecular Formula:
- C25H27F3N2O4S2HCl
- Molecular Weight:
- 0
- MDL Number:
- MFCD11114384
- MOL File:
- 754240-09-0.mol
- MSDS File:
- SDS
| Melting point | >195°C (dec.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: soluble10mg/mL, clear |
| form | powder |
| color | white to beige |
| CAS DataBase Reference | 754240-09-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
EHT1864 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E1657 | EHT 1864 ≥98% (HPLC) | 754240-09-0 | 10mg | $689 | 2024-03-01 | Buy |
| Cayman Chemical | 17258 | EHT 1864 ≥98% | 754240-09-0 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17258 | EHT 1864 ≥98% | 754240-09-0 | 5mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 17258 | EHT 1864 ≥98% | 754240-09-0 | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 17258 | EHT 1864 ≥98% | 754240-09-0 | 50mg | $911 | 2024-03-01 | Buy |
EHT1864 Chemical Properties,Uses,Production
Uses
EHT 1864 is an inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively. It can reverse transformation of NIH 3T3 fibroblasts caused by constitutively activated Rac1, as well as Rac-dependent transformation caused by Tiam1 or Ras. EHT 1864 inhibits APP processing by γ-secretase, reducing Αβ40 and Αβ42 accumulation. It blocks breast cancer cell invasion in a collagen matrix assay and, at 10 μM, increases the size but decreases the density of dendritic spines of hippocampal neurons in culture.
Uses
EHT 1864 has been used to study the regulation of the adapter protein dishevelled-1 ubiquitylation by Rac1 activity.
Uses
EHT 1864 is a potent Rac family GTPase inhibitor.
Biological Activity
Inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (K D values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces β -amyloid peptide production in vivo .
Biochem/physiol Actions
EHT 1864 inhibits Rac function. It prevents Aβ40 and Aβ42 production in vitro without direct inhibition of g-secretase.
storage
Store at +4°C
References
[1] shutes a, onesto c, picard v, et al. specificity and mechanism of action of eht 1864, a novel small molecule inhibitor of rac family small gtpases. journal of biological chemistry, 2007, 282(49): 35666-35678.
EHT1864 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5905 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
