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EHT1864

CAS No.
754240-09-0
Chemical Name:
EHT1864
Synonyms
CS-1343;CS-1239;EHT 1864;EHT-1864 2HCl;EHT 1864, >=98%;EHT1864 USP/EP/BP;EHT-1864;EHT-1864;5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride;2-(morpholin-4-ylmethyl)-5-[5-[7-(trifluoromethyl)quinolin-4-yl]sulfanylpentoxy]pyran-4-one,dihydrochloride;2-(Morpholinomethyl)-5-((5-((7-(trifluoromethyl)quinolin-4-yl)thio)pentyl)oxy)-4H-pyran-4-one dihydrochloride
CBNumber:
CB12095478
Molecular Formula:
C25H27F3N2O4S2HCl
Molecular Weight:
0
MDL Number:
MFCD11114384
MOL File:
754240-09-0.mol
MSDS File:
SDS
Modify Date:2022-11-11 13:01:00

EHT1864 Properties

Melting point >195°C (dec.)
storage temp. 2-8°C
solubility H2O: soluble10mg/mL, clear
form powder
color white to beige
CAS DataBase Reference 754240-09-0

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3

EHT1864 price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E1657 EHT 1864 ≥98% (HPLC) 754240-09-0 10mg $629 2022-05-15 Buy
Cayman Chemical 17258 EHT 1864 ≥98% 754240-09-0 1mg $28 2022-04-27 Buy
Cayman Chemical 17258 EHT 1864 ≥98% 754240-09-0 5mg $107 2022-04-27 Buy
Cayman Chemical 17258 EHT 1864 ≥98% 754240-09-0 10mg $190 2022-04-27 Buy
Cayman Chemical 17258 EHT 1864 ≥98% 754240-09-0 50mg $811 2022-04-27 Buy
Product number Packaging Price Buy
E1657 10mg $629 Buy
17258 1mg $28 Buy
17258 5mg $107 Buy
17258 10mg $190 Buy
17258 50mg $811 Buy

EHT1864 Chemical Properties,Uses,Production

Uses

EHT 1864 is a potent Rac family GTPase inhibitor.

Uses

EHT 1864 is an inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively. It can reverse transformation of NIH 3T3 fibroblasts caused by constitutively activated Rac1, as well as Rac-dependent transformation caused by Tiam1 or Ras. EHT 1864 inhibits APP processing by γ-secretase, reducing Αβ40 and Αβ42 accumulation. It blocks breast cancer cell invasion in a collagen matrix assay and, at 10 μM, increases the size but decreases the density of dendritic spines of hippocampal neurons in culture.

Uses

EHT 1864 has been used to study the regulation of the adapter protein dishevelled-1 ubiquitylation by Rac1 activity.

Biological Activity

Inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (K D values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces β -amyloid peptide production in vivo .

Biochem/physiol Actions

EHT 1864 inhibits Rac function. It prevents Aβ40 and Aβ42 production in vitro without direct inhibition of g-secretase.

EHT1864 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 82)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
21-51619050 ivan@atkchemical.com China 31212 60
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22973 58
career henan chemical co
+86-0371-86658258 factory@coreychem.com China 29828 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 Service@dideu.com China 29991 58
Hefei Hirisun Pharmatech Co., Ltd
+8615056975894 shawn@hirisunpharm.com CHINA 9923 58
InvivoChem
+1-708-3101919 sales@invivochem.net United States 6395 58
Golden Pharma Co., Limited
+undefined13575724153 sales1@zjgoldpharm.com China 5552 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+8617767106207 sales@molcore.com China 49756 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19995 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 132094 58

View Lastest Price from EHT1864 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2019-12-31 EHT 1864
754240-09-0
US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • EHT 1864
    754240-09-0
  • US $1.00 / KG
  • Min98% HPLC
  • Career Henan Chemical Co

EHT1864 Spectrum

5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride EHT 1864 2-(4-morpholinylmethyl)-5-[[5-[[7-(trifluoromethyl)-4-quinolinyl]thio]pentyl]oxy]-4H-pyran-4-one,hydrochloride (1:2) EHT 1864, >=98% 2-(morpholin-4-ylmethyl)-5-[5-[7-(trifluoromethyl)quinolin-4-yl]sulfanylpentoxy]pyran-4-one,dihydrochloride CS-1239 CS-1343 EHT-1864;EHT-1864 EHT-1864 2HCl EHT1864 USP/EP/BP 4H-Pyran-4-one,2-(4-morpholinylmethyl)-5-[[5-[[7-(trifluoromethyl)-4-quinolinyl]thio]pentyl]oxy]-,hydrochloride (1:2) 2-(Morpholinomethyl)-5-((5-((7-(trifluoromethyl)quinolin-4-yl)thio)pentyl)oxy)-4H-pyran-4-one dihydrochloride 754240-09-0 C25H29Cl2F3N2O4S C25H27F3N2O4S2HCl Inhibitors