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Lecithin

Lecithin
Lecithin structure
CAS No.
8002-43-5
Chemical Name:
Lecithin
Synonyms
PC;kelecin;LECITHIN;froM Egg;Alcolec-S;granulestin;LIPOID(R)E80;L-α-Lecithin;Lecithin, NF;Phospholutein
CBNumber:
CB1242041
Molecular Formula:
C42H80NO8P
Formula Weight:
758.06
MOL File:
8002-43-5.mol

Lecithin Properties

Density 
d424 1.0305
Flash point:
57 °C
storage temp. 
-20°C
solubility 
chloroform: 0.1 g/mL, slightly hazy, slightly yellow to deep orange
form 
solution
color 
Pale Brown to Yellow
Water Solubility 
NEGLIGIBLE
Merck 
14,5429
BRN 
5209585
Stability:
Stable, but light, heat, moisture and air-sensitive. Incompatible with strong oxidizing agents.
InChIKey
FWMYJLDHIVCJCT-VSZGHEPYSA-N
CAS DataBase Reference
8002-43-5
FDA 21 CFR
184.1400; 582.1400; 175.300; 310.545
Substances Added to Food (formerly EAFUS)
LECITHIN
SCOGS (Select Committee on GRAS Substances)
Lecithin
EWG's Food Scores
1-3
FDA UNII
1T6N4D9YV6
EPA Substance Registry System
Lecithins (8002-43-5)
Pesticides: Freedom of Information Act (FOIA)
Lecithin
Cosmetics Info
Lecithin
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS08,GHS02,GHS07
Signal word  Danger
Hazard statements  H302-H315-H319-H331-H336-H351-H361d-H372-H225
Precautionary statements  P201-P261-P304+P340+P312-P305+P351+P338-P308+P313-P403+P233-P210-P280-P337+P313-P403+P235
Hazard Codes 
Risk Statements 
Safety Statements 
WGK Germany  3
RTECS  OG7565000
1-8-10
TSCA  Yes
HS Code  29239000
Toxicity LD50 oral in rat: > 8mL/kg
NFPA 704
0
1 0

Lecithin price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 429415 L-α-Lecithin, Soybean 8002-43-5 100gm $271 2021-12-16 Buy
Sigma-Aldrich 44924 L-α-Phosphatidylcholine for microbiology 8002-43-5 500g $1620 2021-12-16 Buy
TCI Chemical L0023 Lecithin from Soybean 8002-43-5 25g $26 2021-12-16 Buy
TCI Chemical L0023 Lecithin from Soybean 8002-43-5 500g $42 2021-12-16 Buy
Alfa Aesar 036486 Lecithin, Refined 8002-43-5 250g $57.3 2021-12-16 Buy

Lecithin Chemical Properties,Uses,Production

Description

Food-grade lecithin is obtained from soybeans and other plant sources. It is a complex mixture of acetone-insoluble phosphatides that consists chiefly of phosphatidyl choline, phosphatidyl etha nolamine, and phosphatidyl inositol, combined with various amounts of other substances such as triglycerides, fatty acids, and carbohydrates. Refined grades of lecithin may contain any of these components in varying proportions and combinations depending on the type of fractionation used. In its oil-free form, the prepon-derance of triglycerides and fatty acids is removed and the product contains 90% or more of phosphatides representing all or certain fractions of the total phosphatide complex. The consistency of both natural grades and refined grades of lecithin may vary from plastic to fluid, depending upon free fatty acid and oil content, and upon the presence or absence of other diluents. Its color varies from light yellow to brown, depending on the source, on crop variations, and on whether it is bleached or unbleached. It is odorless or has a characteristic, slight nutlike odor and a bland taste. Edible diluents, such as cocoa butter and vegetable oils, often replace soybean oil to improve functional and flavor characteris tics. Lecithin is only partially soluble in water, but it readily hydrates to form emulsions. The oil-free phosphatides are soluble in fatty acids, but are practically insoluble in fixed oils. When all phosphatide fractions are present, lecithin is partially soluble in alcohol and practically insoluble in acetone.

Description

Phosphatidylcholine is the most abundant phospholipid in mammalian, plant, and yeast cells. It is found mainly in the outer leaflet of cell membranes and can make up approximately half of the total phospholipids. In mammalian tissues, phosphatidylcholine commonly contains a saturated and unsaturated fatty acid at the C-1 and C-2 positions of glycerol, respectively. It is a substrate for various enzymes in cell signaling pathways that is cleaved by phospholipases into diacylglycerol and phosphocholine or phosphatidic acid and choline. Phosphatidylcholines (egg) is a mixture of phosphatidylcholines isolated from chicken egg with fatty acids of variable chain lengths acylated to the sn-1 and sn-2 positions. [Matreya, LLC. Catalog No. 1044]

Chemical Properties

Lecithins vary greatly in their physical form, from viscous semiliquids to powders, depending upon the free fatty acid content. They may also vary in color from brown to light yellow, depending upon whether they are bleached or unbleached or on the degree of purity. When they are exposed to air, rapid oxidation occurs, also resulting in a dark yellow or brown color.
Lecithins have practically no odor. Those derived from vegetable sources have a bland or nutlike taste, similar to that of soybean oil.

Chemical Properties

solid

Occurrence

Lecithin is found in foods such as eggs, beef liver, and peanuts. Commercial sources are available

Uses

Edible and digestible surfactant and emulsifier of natural origin. Used in margarine, chocolate and in the food industry in general. In pharmaceuticals and cosmetics. Many other industrial uses, e.g. treating leather and textiles.

Uses

lecithin (hydrogenated) is an emulsifier.

Uses

lecithin is a natural emollient, emulsifier, anti-oxidant, and spreading agent, lecithin is a hydrophilic ingredient that attracts water and acts as a moisturizer. generally obtained for cosmetic products from eggs and soybeans, it is found in all living organisms.

Uses

egg lecithin is emollient and particularly recommended for sensitive skin.

Uses

Lecithin is an emulsifier that is a mixture of phosphatides which are typically surface-active. it is now commercially obtained from soy- beans; previously it was obtained from egg yolk. it is used in marga- rine as an emulsifier and antispatter agent; in chocolate manufacture it controls flow properties by reducing viscosity and reducing the cocoa butter content from 3 to 5%; it is used as a wetting agent in cocoa powder, fillings, and beverage powders; an antisticking agent in griddling fat; and in baked goods to assist the shortening mix with other dough ingredients and to stabilize air cells. typical usage levels range from 0.1 to 1.0%.

Definition

ChEBI: A glycerophosphocholine compound having O-acyl substituents at both the 1- and 2-positions of the glycerol. It is a major constituent of cell membranes.

Production Methods

Lecithins are essential components of cell membranes and, in principle, may be obtained from a wide variety of living matter. In practice, however, lecithins are usually obtained from vegetable products such as soybean, peanut, cottonseed, sunflower, rapeseed, corn, or groundnut oils. Soybean lecithin is the most commercially important vegetable lecithin. Lecithin obtained from eggs is also commercially important and was the first lecithin to be discovered.
Vegetable lecithins are obtained as a by-product in the vegetable oil refining process. Polar lipids are extracted with hexane and, after removal of the solvent, a crude vegetable oil is obtained. Lecithin is then removed from the crude oil by water extraction. Following drying, the lecithin may be further purified.
With egg lecithin, a different manufacturing process must be used since the lecithin in egg yolks is more tightly bound to proteins than in vegetable sources. Egg lecithin is thus obtained by solvent extraction from liquid egg yolks using acetone or from freeze-dried egg yolks using ethanol (95%).
Synthetic lecithins may also be produced.

General Description

Phosphatidylcholine belongs to the class of glycerophoshpolipids and contains choline as the head-group. Choline is attached to the glycerol of fatty acids ester-bound to backbone. It is the major phospholipid found in eukaryotic organism.

Pharmaceutical Applications

Lecithins are used in a wide variety of pharmaceutical applications. They are also used in cosmetics and food products.
Lecithins are mainly used in pharmaceutical products as dispersing, emulsifying, and stabilizing agents, and are included in intramuscular and intravenous injections, parenteral nutrition formulations, and topical products such as creams and ointments.
Lecithins are also used in suppository bases, to reduce the brittleness of suppositories, and have been investigated for their absorption-enhancing properties in an intranasal insulin formulation. Lecithins are also commonly used as a component of enteral and parenteral nutrition formulations.
There is evidence that phosphatidylcholine (a major component of lecithin) is important as a nutritional supplement to fetal and infant development. Furthermore, choline is a required component of FDA-approved infant formulas. Other studies have indicated that lecithin can protect against alcohol cirrhosis of the liver, lower serum cholesterol levels, and improve mental and physical performance.
Liposomes in which lecithin is included as a component of the bilayer have been used to encapsulate drug substances; their potential as novel delivery systems has been investigated. This application generally requires purified lecithins combined in specific proportions.
Therapeutically, lecithin and derivatives have been used as a pulmonary surfactant in the treatment of neonatal respiratory distress syndrome.

Biochem/physiol Actions

It also acts as a source of lipid messengers/ bioactive lipids including: lysophosphatidylcholine, diacylglycerol, phosphatidic acid, lysophosphatidylcholine, arachidonic acid and platelet activating factor. Phosphatidylcholine is produced in the liver by the CDP-choline (cytidine diphosphocholine) pathway.

Safety

Lecithin is a component of cell membranes and is therefore consumed as a normal part of the diet. Although excessive consumption may be harmful, it is highly biocompatible and oral doses of up to 80 g daily have been used therapeutically in the treatment of tardive dyskinesia. When used in topical formulations, lecithin is generally regarded as a nonirritant and nonsensitizing material. The Cosmetic Ingredients Review Expert Panel (CIR) has reviewed lecithin and issued a tentative report revising the safe concentration of the material from 1.95% to 15.0% in rinse-off and leave-in products. They note, however, that there are insufficient data to rule on products that are likely to be inhaled.

storage

Lecithins decompose at extreme pH. They are also hygroscopic and subject to microbial degradation. When heated, lecithins oxidize, darken, and decompose. Temperatures of 160–180°C will cause degradation within 24 hours.
Fluid or waxy lecithin grades should be stored at room temperature or above; temperatures below 10°C may cause separation.
All lecithin grades should be stored in well-closed containers protected from light and oxidation. Purified solid lecithins should be stored in tightly closed containers at subfreezing temperatures.

Purification Methods

Lecithin from hen egg white is purified by solvent extraction and chromatography on alumina. It is suspended in H2O and kept frozen until required [Lee & Hunt J Am Chem Soc 106 7411 1984, Singleton et al. J Am Oil Chem Soc 42 53 1965]. For purification of commercial egg lecithin, see Pangborn [J Biol Chem 188 471 1951].

Incompatibilities

Incompatible with esterases owing to hydrolysis.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; IM and IV injections; otic preparations; oral capsules, suspensions and tablets; rectal, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Lecithin Preparation Products And Raw materials

Raw materials

Preparation Products


Lecithin Suppliers

Global( 459)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
Qingdao Trust Agri Chemical Co.,Ltd
13573296305 008613573296305
0532-87927000 aroma@qdtrustagri.com CHINA 190 58
Baoji Guokang Healthchem co.,ltd
09178656283
cngksw@aliyun.com CHINA 9466 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9128 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1011 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
+8619933070948
claire@hbyingong.com China 684 58

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View Lastest Price from Lecithin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-20 food additives Soya Lecithin with best price
8002-43-5
US $1.00 / KG 1KG 99% 20tons Shanxi Naipu Import and Export Co.,Ltd
2022-01-20 food additives Soya Lecithin with best price
8002-43-5
US $1.00 / KG 1KG 99% 20tons Shanxi Naipu Import and Export Co.,Ltd
2022-01-20 Lecithins
8002-43-5
US $1.00 / g 10g 99.5% 1000kg Guangzhou Biocar Biotechnology Co.,Ltd.

Lecithin Spectrum


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