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Nicardipine hydrochloride

Nicardipine hydrochloride
Nicardipine hydrochloride
CAS No.
54527-84-3
Chemical Name:
Nicardipine hydrochloride
Synonyms
YC-93;dafil;dagan;loxen;lincil;Vasonas;Dacarel;Barizin;Aprovan;NICODEL
CBNumber:
CB1244267
Molecular Formula:
C26H30ClN3O6
Formula Weight:
515.99
MOL File:
54527-84-3.mol

Nicardipine hydrochloride Properties

Melting point:
176-1780C
storage temp. 
2-8°C
solubility 
DMSO: ~1 mg/mL
form 
powder
color 
yellow
Merck 
14,6495
CAS DataBase Reference
54527-84-3(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  23/24/25
Safety Statements  36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  US7972100
HazardClass  6.1(b)
PackingGroup  III
Toxicity LD50 in male, female rats (mg/kg): 634, 557 orally; 18.1, 25.0 i.v.; in male, female mice: 634, 650 orally; 20.7, 19.9 i.v. (Odani, Sado)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

Nicardipine hydrochloride price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N7510 Nicardipine hydrochloride powder, ≥98% 54527-84-3 1g $103 2018-11-13 Buy
Sigma-Aldrich 1463224 Nicardipine hydrochloride United States Pharmacopeia (USP) Reference Standard 54527-84-3 200mg $348 2018-11-13 Buy
TCI Chemical N0635 Nicardipine Hydrochloride >98.0%(HPLC)(T) 54527-84-3 5g $115 2018-11-22 Buy
TCI Chemical N0635 Nicardipine Hydrochloride >98.0%(HPLC)(T) 54527-84-3 25g $336 2018-11-22 Buy
Alfa Aesar J61269 Nicardipine hydrochloride, 98% 54527-84-3 5g $263 2018-11-13 Buy

Nicardipine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Uses

anesthetic (topical)

Uses

Dihydropyridine calcium channel blocker. Antianginal; antihypertensive

Uses

Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).

brand name

Cardene(PDL Biopharma); Cardene (Roche).

Nicardipine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Nicardipine hydrochloride Suppliers

Global( 119)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2548 55
Hubei Jusheng Technology Co.,Ltd.
86-155-27864001
peter@hubeijusheng.com CHINA 18004 58
Haihang Industry Co.,Ltd
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+86 531 8582 1093 export@haihangchem.com CHINA 4530 58
Shenzhen Nexconn Pharmatechs Ltd
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Shenzhen Nexconn Pharmatechs Ltd. 0755-89396975/0755-89396905
+86-755-22712255 admin@nexconn.com China 294 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40395 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15926 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24648 81

Nicardipine hydrochloride Spectrum


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