Pirenzepine hydrochloride
- CAS No.
- 29868-97-1
- Chemical Name:
- Pirenzepine hydrochloride
- Synonyms
- Tabe;Maghen;Leblon;l-s519;Ulcosan;Renzepin;Gasteril;ls519cl2;Bisvanil;Gastricur
- CBNumber:
- CB1245572
- Molecular Formula:
- C19H22ClN5O2
- Molecular Weight:
- 387.87
- MDL Number:
- MFCD00055214
- MOL File:
- 29868-97-1.mol
- MSDS File:
- SDS
| Melting point | 248-250°C |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | white |
| Water Solubility | Soluble to 100 mM in water |
| Sensitive | Hygroscopic |
| CAS DataBase Reference | 29868-97-1(CAS DataBase Reference) |
| FDA UNII | 10YM403FLS |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H317-H402 | |||||||||
| Precautionary statements | P501-P261-P273-P272-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P333+P313-P301+P312+P330 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | UU7883000 | |||||||||
| HS Code | 2933.99.7500 | |||||||||
| Toxicity | dog,LD50,intravenous,62500ug/kg (62.5mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988. | |||||||||
| NFPA 704 |
|
Pirenzepine hydrochloride price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P7412 | Pirenzepine dihydrochloride ≥98% (TLC), powder | 29868-97-1 | 500mg | $113 | 2024-03-01 | Buy |
| Sigma-Aldrich | P7412 | Pirenzepine dihydrochloride ≥98% (TLC), powder | 29868-97-1 | 1g | $200 | 2024-03-01 | Buy |
| TCI Chemical | P2457 | Pirenzepine Dihydrochloride | 29868-97-1 | 200MG | $42 | 2024-03-01 | Buy |
| TCI Chemical | P2457 | Pirenzepine Dihydrochloride | 29868-97-1 | 1G | $165 | 2024-03-01 | Buy |
| Alfa Aesar | J62252 | Pirenzepine dihydrochloride, 99% | 29868-97-1 | 1g | $172 | 2024-03-01 | Buy |
Pirenzepine hydrochloride Chemical Properties,Uses,Production
Description
Pirenzepine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 11.48 nM). It is selective for M1 over M2, M3, and M4 receptors (Kis = 602.56, 151.36, and 199.53 nM, respectively). Pirenzepine inhibits ascending reflex contraction of the circular smooth muscle in isolated guinea pig ileal segments induced by intraluminal balloon inflation (IC50 = 501.19 nM). It inhibits methacholine-induced increases in ileal pressure in guinea pigs (ID50 = 724.44 nmol/kg). Pirenzepine inhibits oxotremorine-induced gastric ulcer, gastric acid secretion, and salivation in rats (ED50s = 13, 37.5, and 620 μg/kg i.v., respectively). It prevents form-deprivation myopia (FDM) in a chick model of experimental myopia.
Chemical Properties
Solid
Originator
Microsules Bernabo, Microsules Bernabo
Uses
An antiulcerative. Tricyclic gastric-acid inhibitor.
Uses
Antiulcerative;M1 antagonist
Manufacturing Process
48.4 g of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzo-diazepin-6-one were refluxed in 900 ml of absolute dioxane for 15 minutes. Thereafter, over a period of 45 minutes, 28 ml of chloroacetyl chloride and 52 ml of triethylamine were simultaneously added dropwise to the mixture. The mixture was refluxed for eight hours and then vacuum-filtered after having cooled. The filtrate was evaporated in vacuum. The crystalline residue was recrystallized from acetonitrile in the presence of activated charcoal. MP: 212°-213°C (with decomposition). Yield: 85% of theory.
A mixture of 67.5 g of 11-chloroacetyl-5,11-dihydro-6H-pyrido[2,3b][1,4]benzodiazepin-6-one, 183 ml of N-methylpiperazine and 1.37 liters of absolute benzene was refluxed for 18 hours. Thereafter, the crystalline precipitate was vacuum filtered off, dissolved in aqueous 20% hydrochloric acid, the solution was evaporated in vacuum, the crystalline residue wasdissolved in 250 ml of water while heating, the solution was admixed with 150 ml of isopropanol and active charcoal, filtered, and 2.5 liters of isopropanol were added to the filtrate. After cooling, the precipitate was vacuum filtered off, yielding 70% of theory of the 5,11-dihydro-11-[(4'-methyl-1'-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride, M.P. 257259°C (decomp.).
The free base of pirenzepine, obtained from the dihydrochloride by making an aqueous solution thereof alkaline with dilute sodium hydroxide and extracting it with chloroform, had MP: 226°-228°C after recrystallization from methanol/ether.
Therapeutic Function
Antiulcer, Antiemetic
General Description
Pirenzepine dihydrochloride is an anticholinergic agent. It is also considered as an antiulcer drug. It is used to treat myopia, gastric and duodenal ulcers. Pirenzepine dihydrochloride induces the dimerization of muscarinic M1 receptors.
Biochem/physiol Actions
Selective M1 muscarinic acetylcholine receptor antagonist.
storage
Store at RT
Pirenzepine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3632 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
View Lastest Price from Pirenzepine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-23 | Pirenzepine hydrochloride
29868-97-1
|
US $30.00 / kg | 1kg | 99% | 1000tons | Henan Bao Enluo International TradeCo.，LTD | |
 |
2021-09-29 | Pirenzepine hydrochloride
29868-97-1
|
US $0.00 / Kg/Bag | 100g | 98.5%-101%; JP | 50kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2021-08-12 | Pirenzepine hydrochloride
29868-97-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Pirenzepine hydrochloride
29868-97-1
- US $30.00 / kg
- 99%
- Henan Bao Enluo International TradeCo.，LTD
-
- Pirenzepine hydrochloride
29868-97-1
- US $0.00 / Kg/Bag
- 98.5%-101%; JP
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Pirenzepine hydrochloride
29868-97-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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