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ChemicalBook >> CAS DataBase List >>2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione

2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione

2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Structure
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione structure
CAS No.
446292-07-5
Chemical Name:
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
Synonyms
C21H2IN3Os .;2-Amino-12-picoline;Rivaroxaban Impurity 50;Rivaroxaban interMediate B;Intermediate of Rivaroxaban 4;-2-(2-Hydroxy-3-((4-(3-oxomorpholino);Rivaroxaban Phthalimido Descarbonyl Impurity;2-[(2R)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}pr...;4-[((2R)-Hydroxy-3-phthaliMido)propylaMine]phenyl-3-Morpholinone;2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-
CBNumber:
CB12468597
Molecular Formula:
C21H21N3O5
Molecular Weight:
395.41
MDL Number:
MFCD11977664
MOL File:
446292-07-5.mol
Last updated:2023-12-26 11:56:33
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2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Properties

Melting point 208-211°C
Boiling point 734.9±60.0 °C(Predicted)
Density 1.421
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO (Slightly), Methanol (Slightly, Heated)
pka 13.91±0.20(Predicted)
form Solid
color White to Off-White
Water Solubility 37mg/L at 20℃
LogP 0.6 at 25℃
CAS DataBase Reference 446292-07-5

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501
HS Code  2922498590

2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC H948920 4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone 446292-07-5 25mg $385 2021-12-16 Buy
TRC H948920 4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone 446292-07-5 50mg $725 2021-12-16 Buy
AK Scientific Z3537 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-mopholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2h)-dione 446292-07-5 100mg $82 2021-12-16 Buy
American Custom Chemicals Corporation CCH0032813 (R)-2-(2-HYDROXY-3-((4-(3-OXOMORPHOLINO)PHENYL)AMINO)PROPYL)ISOINDOLINE-1,3-DIONE 95.00% 446292-07-5 1G $402.15 2021-12-16 Buy
AK Scientific Z3537 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-mopholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2h)-dione 446292-07-5 1g $139 2021-12-16 Buy
Product number Packaging Price Buy
H948920 25mg $385 Buy
H948920 50mg $725 Buy
Z3537 100mg $82 Buy
CCH0032813 1G $402.15 Buy
Z3537 1g $139 Buy

2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Rivaroxaban intermediate.

Uses

4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone is a Rivaroxaban (R538000(P)) intermediate. Rivaroxaban is a novel antithrombotic agent. It is also a highly potent and selective, direct FXa inhibitor.

Flammability and Explosibility

Non flammable

2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione synthesis

161596-47-0
438056-69-0
446292-07-5
Synthesis of 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione from (S)-(+)-Glycidyl Phthalimide and 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE

2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Preparation Products And Raw materials

Raw materials

4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)aMino)phenyl]Morpholin-3-one (S)-(+)-Glycidyl Phthalimide 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE 3-Morpholinone, 4-phenyl- 4-(4-NITROPHENYL)MORPHOLIN-3-ONE
N-(2,3-EPOXYPROPYL)PHTHALIMIDE 2-Anilinoethanol p-Phenylenediamine 1H-Isoindol-1-one, 3-hydroxy- Potassium phthalimide

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Preparation Products

2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Suppliers

Global( 243)Suppliers
Supplier Tel Email Country ProdList Advantage
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 885 50
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Anqing Chico Pharmaceutical Co., Ltd. 		15380796838 chloewu@chicopharm.cn CHINA 341 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shanghai Arbor Chemical Co., Ltd. 		021-60451682 act@arborchemical.com CHINA 906 58
Anhui Dexinjia Biopharm Co., Ltd 		+86-531-82375818 +86-15064153060 alice@jndxj.com China 309 58
Supplier Advantage
Frapp's ChemicalNFTZ Co., Ltd. 		50
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Anqing Chico Pharmaceutical Co., Ltd. 		58
career henan chemical co 		58
Shanghai Arbor Chemical Co., Ltd. 		58
Anhui Dexinjia Biopharm Co., Ltd 		58

View Lastest Price from 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione pictures 2024-04-24 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
446292-07-5
 US $100.00-2500.00 / KG 1KG 99% 2MT per month Anhui Dexinjia Biopharm Co., Ltd
2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-1H-ISOINDOLE- 1,3(2H)-DIONE pictures 2023-05-26 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-1H-ISOINDOLE- 1,3(2H)-DIONE
446292-07-5
 US $0.00-0.00 / Kg 1Kg 99% 1-10000kgs Changzhou Rokechem Technology Co., Ltd.
1H-isoindole-1,3(2H) -Dione, 2-[(2R) -2-Hydroxy-3 -[[4-(3-OXO-4-morpholinyl)PHENYL]AMINO]PROPYL]- pictures 2022-10-07 1H-isoindole-1,3(2H) -Dione, 2-[(2R) -2-Hydroxy-3 -[[4-(3-OXO-4-morpholinyl)PHENYL]AMINO]PROPYL]-
446292-07-5
 US $30.00-28.00 / Kg 1Kg 99.0% up 50 tons per month Xinxiang Hongqi District Houyuan Trading Co.,Ltd

446292-07-5(2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione)Related Search:

1,2-BenzenedicarboxaMide, N1,N2-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 2-QuinazolineMethanol, 4-Methyl- Rivaroxaban Impurity 34 (R)-N-Glycidylphthalimide 4,5-DICHLOROTHIOPHENE-2-CARBOXYLIC ACID
2-Thiophenecarboxylic acid 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- Rivaroxaban POLYSTYRENE IODOSOACETATE 1,2-Cyclohexanedione
(S)-(+)-Epichlorohydrin 4-(4-NITROPHENYL)MORPHOLIN-3-ONE (S)-(+)-Glycidyl Phthalimide 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)aMino)phenyl]Morpholin-3-one (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl
5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]-

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1H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]- 4-[((2R)-Hydroxy-3-phthaliMido)propylaMine]phenyl-3-Morpholinone 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2H)-dione 2-[(2R)-2-hydroxy-3-{[4-(3-oxoMorpholin-4-yl)phenyl]aMino}p ropyl]-1H-isoindole-1,3(2H)-dione (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)-amino)propyl)isoindoline-1,3-dione Rivaroxaban interMediate B 2-[(2R)-2-hydroxy-3-[4-(3-oxomorpholin-4-yl)anilino]propyl]isoindole-1,3-dione Rivaroxaban Phthalimido Descarbonyl Impurity 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]- -2-(2-Hydroxy-3-((4-(3-oxomorpholino) Rivaroxaban Impurity 10/4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone Rivaroxaban Impurity 50 H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]- R –(2-Hydroxy-3-((4-(3-Oxo morpholino) Phenyl) Amino) Propyl) Isoindoline-1,3-dione 2-Amino-12-picoline 2-[(2R)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}pr... TIANFUCHEM--446292-07-5---1H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]- C21H2IN3Os . Intermediate of Rivaroxaban 4 446292-07-5 Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Intermediate of Rivaroxaban