N-Tosyl-4-bromo-2-iodo-7-azaindole
- CAS No.
- 480423-17-4
- Chemical Name:
- N-Tosyl-4-bromo-2-iodo-7-azaindole
- Synonyms
- N-Tosyl-4-bromo-2-iodo-7-azaindole;4-bromo-2-iodo-1-tosyl-7-azaindole;4-Bromo-2-iodo-N-tosyl-7-azaindole;4-Bromo-2-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine;4-bromo-2-iodo-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine;4-Bromo-2-iodo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 4-broMo-2-iodo-1-[(4-Methylphenyl)sulfonyl]-
- CBNumber:
- CB12471359
- Molecular Formula:
- C14H10BrIN2O2S
- Molecular Weight:
- 477.11
- MDL Number:
- MFCD11109388
- MOL File:
- 480423-17-4.mol
- MSDS File:
- SDS
N-Tosyl-4-bromo-2-iodo-7-azaindole price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FB152554 | 4-Bromo-2-iodo-N-tosyl-7-azaindole | 480423-17-4 | 2mg | $59 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB152554 | 4-Bromo-2-iodo-N-tosyl-7-azaindole | 480423-17-4 | 5mg | $117 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB152554 | 4-Bromo-2-iodo-N-tosyl-7-azaindole | 480423-17-4 | 10mg | $203 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB152554 | 4-Bromo-2-iodo-N-tosyl-7-azaindole | 480423-17-4 | 25mg | $405 | 2021-12-16 | Buy |
| AK Scientific | 6664DD | 4-Bromo-2-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine | 480423-17-4 | 25mg | $596 | 2021-12-16 | Buy |
N-Tosyl-4-bromo-2-iodo-7-azaindole Chemical Properties,Uses,Production
Synthesis
![4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE](/CAS/GIF/348640-07-3.gif)
348640-07-3
480423-17-4
A hexane solution of n-butyllithium (1.6 M, 41.1 mL, 65.8 mmol) was added dropwise over 5 min to a solution of diisopropylamine (10.5 mL, 74.7 mmol) in 2-methyltetrahydrofuran (100 mL) under nitrogen protection, keeping the temperature at -78 °C. After stirring for 60 min, the resulting solution was transferred via cannula to a solution of 4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine (21 g, 60 mmol) in 2-methyltetrahydrofuran (700 mL). Stirring was continued at -78 °C for 90 min. Subsequently, solid iodine (21.3 g, 83.7 mmol) was added all at once and stirred at -78 °C for 60 min, after which it was slowly warmed to -10 °C. The reaction mixture was quenched with saturated aqueous ammonium chloride solution (1 L) and the organic layer was washed sequentially with saturated aqueous sodium bisulfite solution (750 mL) and saturated aqueous sodium chloride solution (50 mL). The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by fast silica gel chromatography using a 20% tert-butyl methyl ether solution in heptane as eluent. The product grades were collected and concentrated to dryness to afford 4-bromo-2-iodo-N-tosyl-7-azaindole (27 g, 93%) as an off-white solid.1H NMR (400 MHz, DMSO-d6, 30 °C): δ 2.35 (s, 3H), 7.16 (s, 1H), 7.41-7.49 (m, 2H), 7.55 (d, J = 5.2 Hz, 1H), 7.95 (d, J = 8.4 Hz, 2H), 8.19 (d, J = 5.2 Hz, 1H). m/z: ES+ [M + H]+ 477.
References
[1] Tetrahedron Letters, 2016, vol. 57, # 42, p. 4718 - 4722
[2] Patent: WO2008/34860, 2008, A1. Location in patent: Page/Page column 94
[3] Patent: WO2008/145688, 2008, A2. Location in patent: Page/Page column 42; 90
[4] Patent: WO2014/139328, 2014, A1. Location in patent: Page/Page column 455
[5] Patent: US2014/275153, 2014, A1. Location in patent: Paragraph 0617
N-Tosyl-4-bromo-2-iodo-7-azaindole Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
N-Tosyl-4-bromo-2-iodo-7-azaindole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Mainchem Co., Ltd. | -- | sarah@mainchem.com | China | 6547 | 58 |
| BeiJing Hwrk Chemicals Limted | 0757-86329057 18934348241 | sales4.gd@hwrkchemical.com | China | 14063 | 55 |