AMG-706
- CAS No.
- 857876-30-3
- Chemical Name:
- AMG-706
- Synonyms
- CS-459;AMG-706;Unii-T6Q3060U91;Diphosphate salt;AMG-706 USP/EP/BP;Motesanib(AMG-706);Motesanib phosphate;Motesanib diphosphate;AMG706; AMG 706; AMG-706;Motesanib, Diphosphate Salt
- CBNumber:
- CB12473858
- Molecular Formula:
- C22H29N5O9P2
- Molecular Weight:
- 569.441282
- MDL Number:
- MFCD12407403
- MOL File:
- 857876-30-3.mol
- MSDS File:
- SDS
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| solubility | ≥28.45 mg/mL in DMSO; insoluble in H2O; ≥3.47 mg/mL in EtOH with ultrasonic |
| form | Powder |
| NCI Dictionary of Cancer Terms | AMG 706 |
| FDA UNII | T6Q3060U91 |
| NCI Drug Dictionary | motesanib diphosphate |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
AMG-706 price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17671 | AMG 706 ≥98% | 857876-30-3 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17671 | AMG 706 ≥98% | 857876-30-3 | 5mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 17671 | AMG 706 ≥98% | 857876-30-3 | 10mg | $211 | 2024-03-01 | Buy |
| Cayman Chemical | 17671 | AMG 706 ≥98% | 857876-30-3 | 50mg | $660 | 2024-03-01 | Buy |
| Usbiological | 474141 | Motesanib diphosphate | 857876-30-3 | 100mg | $1805 | 2021-12-16 | Buy |
AMG-706 Chemical Properties,Uses,Production
Uses
An oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.
Uses
Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.
Biological Activity
motesanib diphosphate is a diphosphate form of motesanib. it is a potent atp-competitive inhibitor of vegfr1/2/3 with ic50 of 2 nm/3 nm/6 nm, respectively [1].vascular endothelial growth factor (vegf) is an important signaling protein involved in both vasculogenesis (the formation of the circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). motesanib (amg 706) is an orally administered small molecule belonging to angiokinase inhibitor class which acts as an antagonist of vegf receptors, platelet-derived growth factor receptors, and stem cell factor receptors.
in vitro
motesanib diphosphate has broad activity against the human vegfr family, and displays >1000 selectivity against egfr, src, and p38 kinase. motesanib diphosphate significantly inhibits vegf-induced cellular proliferation of huvecs with an ic50 of 10 nm, while displaying little effect at bfgf-induced proliferation with an ic50 of >3,000 nm. motesanib diphosphate also potently inhibits pdgf-induced proliferation and scf-induced c-kit phosphorylation with ic50 of 207 nm and 37 nm, respectively, but not effective against the egf-induced egfr phosphorylation and cell viability of a431 cells [1]. althouth displaying little antiproliferative activity on cell growth of huvecs alone, motesanib diphosphate treatment significantly sensitizes the cells to fractionated radiation [2].
in vivo
oral administration of amg 706 potently inhibited vegf-induced angiogenesis in the rat corneal model and induced regression of established a431 xenografts. amg 706 was well tolerated and had no significant effects o amg 706n body weight or on the general health of the animals. histologic analysis of tumor xenografts from amg 706–treated animals revealed an increase in endothelial apoptosis and a reduction in blood vessel area that preceded an increase in tumor cell apoptosis. in summary, amg 706 is an orally bioavailable, well-tolerated multikinase inhibitor that is presently under clinical investigation for the treatment of human malignancies [1].
target
VEGFR
AMG-706 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29525 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
