ChemicalBook >> CAS DataBase List >>4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide

4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide

4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide structure

CAS No.: 870223-96-4

Chemical Name:: 4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide

Synonyms: AMG-Tie2;AMG-Tie2-1;PubChem22413;AMG-Tie-2-1,AMGTie21,AMG Tie2 1;4-Methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)b;4-methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide;4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide;Benzamide, 4-methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-;870223-96-4; AMG-TIE2; AMG-TIE2-1; 4-METHYL-3-(3-(2-(METHYLAMINO)PYRIMIDIN-4-YL)PYRIDIN-2-YLOXY)-N-(3-(TRIFLUOROMETHYL)PHENYL)BENZAMIDE; 4-METHYL-3-[[3-[2-(METHYLAMINO)-4-PYRIMIDINYL]-2-PYRIDINYL]OXY]-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE; PUBCHEM22413

CBNumber:: CB12484979

Molecular Formula:: C25H20F3N5O2

Molecular Weight:: 479.45

MDL Number:: MFCD16038641

MOL File:: 870223-96-4.mol

MSDS File:: SDS

Last updated:2023-05-21 10:59:17

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4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide Properties

Density	1.357
storage temp.	Store at -20°C
solubility	DMF: 10mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL
form	A solid

4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	28850	AMG-Tie2-1	870223-96-4	1mg	$44	2024-03-01	Buy
Cayman Chemical	28850	AMG-Tie2-1	870223-96-4	25mg	$745	2024-03-01	Buy
Cayman Chemical	28850	AMG-Tie2-1	870223-96-4	5mg	$202	2024-03-01	Buy
Cayman Chemical	28850	AMG-Tie2-1	870223-96-4	10mg	$384	2024-03-01	Buy
Adipogen Life Sciences	SYN-1008-M005	AMG-Tie2-1 ≥95%	870223-96-4	5mg	$421	2021-12-16	Buy

Product number	Packaging	Price	Buy
28850	1mg	$44	Buy
28850	25mg	$745	Buy
28850	5mg	$202	Buy
28850	10mg	$384	Buy
SYN-1008-M005	5mg	$421	Buy

4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide Chemical Properties,Uses,Production

Description

AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2) with IC₅₀ values of 1 and 3 nM, respectively, in a homogenous time-resolved fluorescence (HTRF) assay. It inhibits angiopoietin 1-induced Tie2 autophosphorylation in EA.hy926 human endothelial cells (IC₅₀ = 10 nM).

Uses

AMG-Tie 2-1 is a pyridinyltriazine Tie-2 kinase inhibitor. A useful research chemical for cancer metabolism research studies.

4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide Suppliers

Global( 51)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Xi’an chemsoar Medical Technology Co., ltd	029-86538357		China	234	57
NCE Biomedical Co.,Ltd.	4000-027-021 \|24 +86-13986109188 \| +86-15623472865 \| +81-08033611988		China	1494	55
SYN\|thesis med chem P/L	+86-021-50720296	service@synkinase.com	China	266	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
InvivoChem	58
LEAPCHEM CO., LTD.	58
Amadis Chemical Company Limited	58
Xi’an chemsoar Medical Technology Co., ltd	57
NCE Biomedical Co.,Ltd.	55
SYN\|thesis med chem P/L	58

4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide AMG-Tie2-1 AMG-Tie2 4-methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide 4-Methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)b 870223-96-4; AMG-TIE2; AMG-TIE2-1; 4-METHYL-3-(3-(2-(METHYLAMINO)PYRIMIDIN-4-YL)PYRIDIN-2-YLOXY)-N-(3-(TRIFLUOROMETHYL)PHENYL)BENZAMIDE; 4-METHYL-3-[[3-[2-(METHYLAMINO)-4-PYRIMIDINYL]-2-PYRIDINYL]OXY]-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE; PUBCHEM22413 PubChem22413 Benzamide, 4-methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]- AMG-Tie-2-1,AMGTie21,AMG Tie2 1 870223-96-4 C25H20F3N5O2