ChemicalBook >> CAS DataBase List >>Brivanib alaninate
Brivanib alaninate
- CAS No.
- 649735-63-7
- Chemical Name:
- Brivanib alaninate
- Synonyms
- CS-362;Bms582664;Bms 582664;Neopterin-13C5;Unii-U2Y5ofn795;Brivanib alaninate;[14C]-Brivanib alaninate;Unii-U2Y5ofn795 USP/EP/BP;Brivanib alaninate BMS-540215;Brivanib alaninate(BMS-582664)
- CBNumber:
- CB12497201
- Molecular Formula:
- C22H24FN5O4
- Molecular Weight:
- 441.46
- MDL Number:
- MFCD22577162
- MOL File:
- 649735-63-7.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:02:57
| Density | 1.42±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | ≥22.05 mg/mL in DMSO; insoluble in H2O; ≥10.03 mg/mL in EtOH |
| form | Yellow powder. |
| pka | 16.08±0.30(Predicted) |
| NCI Dictionary of Cancer Terms | brivanib alaninate |
| FDA UNII | U2Y5OFN795 |
| NCI Drug Dictionary | brivanib alaninate |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H361-H302-H360 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501 | |||||||||
| NFPA 704 |
|
Brivanib alaninate price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26081 | Brivanib Alaninate | 649735-63-7 | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 26081 | Brivanib Alaninate | 649735-63-7 | 50mg | $926 | 2024-03-01 | Buy |
| Cayman Chemical | 26081 | Brivanib Alaninate | 649735-63-7 | 10mg | $209 | 2024-03-01 | Buy |
| Cayman Chemical | 26081 | Brivanib Alaninate | 649735-63-7 | 25mg | $492 | 2024-03-01 | Buy |
| TRC | B677640 | BrivanibAlaninate | 649735-63-7 | 50mg | $875 | 2021-12-16 | Buy |
Brivanib alaninate Chemical Properties,Uses,Production
Uses
BMS-582664 is an oral VEGFR/FGFR inhibitor for VEGFR2, Flk1, VEGFR1 and FGFR1 with IC50 of 25 nM, 89 nM, 380 nM and 148 nM, respectively.
Uses
A novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor.
Definition
ChEBI: Brivanib alaninate is a carboxylic ester resulting from the formal condensation of the carboxy group of L-alanine with the hydroxy group of brivanib. It is a prodrug of brivanib (BMS-540215), a potent oral dual inhibitor of VEGFR-2 and FGFR-1 (IC50 of 25 nM and 148 nM, respectively) and was in development for the treatment of hepatocellular and colon carcinomas. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, a prodrug, an apoptosis inducer, a fibroblast growth factor receptor antagonist and an angiogenesis inhibitor. It is a pyrrolotriazine, an aromatic ether, a fluoroindole, a diether, a carboxylic ester and a L-alanine derivative. It is functionally related to a brivanib.
target
VEGFR2
Brivanib alaninate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 148)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
View Lastest Price from Brivanib alaninate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-25 | Unii-U2Y5ofn795
649735-63-7
|
US $0.10 / KG | 1KG | 95%-99% | 1kg; 100kg; 1000kg | Career Henan Chemical Co |
-
- Unii-U2Y5ofn795
649735-63-7
- US $0.10 / KG
- 95%-99%
- Career Henan Chemical Co
649735-63-7(Brivanib alaninate)Related Search:
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Brivanib alaninate BMS-540215
(1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester Brivanib alaninate (BMS-582664)
Bms 582664
Bms582664
Brivanib alaninate
L-Alanine, (1R)-2-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo(2,1-F)(1,2,4)triazin-6-yl)oxy)-1-methylethyl ester
Unii-U2Y5ofn795
(1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester
[14C]-Brivanib alaninate
(S)-(R)-1-((4-((5-Fluoro-2-methyl-1H-indol-6-yl)oxy)-5-methylpyrrolo-[2,1-f][1,2,4]triazin-6-y
Brivanib alaninate(BMS-582664)
BMS-582664;BMS 582664;BMS582664
CS-362
Unii-U2Y5ofn795 USP/EP/BP
(R)-(S)-1-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)propan-2-yl 2-aminopropanoate
Neopterin-13C5
649735-63-7
C22H24FN5O4
Inhibitors
Anti-cancer & immunity
Aromatics
Chiral Reagents
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals