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Piperine

Piperine
Piperine structure
CAS No.
94-62-2
Chemical Name:
Piperine
Synonyms
Piperin;PIPERINE;FEMA 2909;Bioperine;NSC 21727;PIPERLINE;PIPERINE(P);Piperine,99%;Piperine,98%;PIPERINE(RG)
CBNumber:
CB1249813
Molecular Formula:
C17H19NO3
Formula Weight:
285.34
MOL File:
94-62-2.mol

Piperine Properties

Melting point:
131-135 °C(lit.)
Boiling point:
427.77°C (rough estimate)
Density 
1.0864 (rough estimate)
refractive index 
1.5400 (estimate)
FEMA 
2909 | PIPERINE
storage temp. 
Refrigerator
solubility 
0.04g/l
form 
Crystalline Powder
pka
12.22(at 18℃)
color 
Off-white to tan or yellow-tan
Water Solubility 
40 mg/L (18 ºC)
Merck 
14,7472
JECFA Number
1600
BRN 
90741
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
MXXWOMGUGJBKIW-YPCIICBESA-N
CAS DataBase Reference
94-62-2(CAS DataBase Reference)
NIST Chemistry Reference
Piperine(94-62-2)
EPA Substance Registry System
Piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol- 5-yl)-1-oxo-2,4-pentadienyl]- (94-62-2)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi,N
Risk Statements  22-21/22-20/21/22-51/53
Safety Statements  22-24/25-36/37-36-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS  TN2321500
Hazard Note  Irritant
TSCA  Yes
HS Code  29399990
Toxicity LD50 orally in Rabbit: 514 mg/kg
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P201 Obtain special instructions before use.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Piperine price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 75047 Piperine analytical standard 94-62-2 50mg $65.9 2018-11-20 Buy
Sigma-Aldrich 1543200 Piperine United States Pharmacopeia (USP) Reference Standard 94-62-2 20mg $308.7 2018-11-20 Buy
TCI Chemical P0460 Piperine >97.0%(HPLC)(N) 94-62-2 1g $20 2018-11-22 Buy
TCI Chemical P0460 Piperine >97.0%(HPLC)(N) 94-62-2 5g $59 2018-11-22 Buy
Alfa Aesar A13510 Piperine, 98% 94-62-2 5g $25.1 2018-11-13 Buy

Piperine Chemical Properties,Uses,Production

Description

Piperine is an alkaloid responsible for the taste and fl avor of pepper. In pure form it exists as a yellow to pale-yellow crystal, with a burning taste and pungent order. It is found naturally in plants in the Piperaceae family, particularly Piper nigrum (black pepper) and Piper longum (Indian long pepper). Piper nigrum is a perennial woody vine that grows to approximately 30 feet. It produces spikelike flowers that hold berries called peppercorns.

Chemical Properties

light yellow powder

History

Hans Christian Oersted (1777 1851) isolated piperine from black pepper in 1819 and published his findings in 1820. Oersted extracted a resin from pepper plants with alcohol, formed a soluble saltby adding hydrochloric acid with alcohol, and then separated piperine from solution by precipitation and distillation. In 1882, Leopold Rügheimer (1850 1917) synthesized piperine from piperinic acid chloride and piperidine. The complete synthesis of piperine was reported in 1894 by Albert Ladenburg (1842 1911) and M. Scholtz. Ladenburg and Scholtz used piperonal (C8H6O3) and acetaldehyde (CH3CHO) to produce piperinic acid (C12H10O4), which was then reacted with thionyl chloride (COCl2) and piperidine (C5H11N) to produce piperine.

Uses

Piperine is used in granular formulations as a pesticide against small animals such as dogs, cats, skunks, raccoons, and squirrels. Piperine pesticides are nontoxic and operate as a repellant when animals smell or test them. Piperine is also incorporated with other compounds to make insecticides; it is effective against houseflies, lice, and various other pests.
Piperine has been used medicinally for thousands of years and this continues today. It is used to treat asthma and chronic bronchitis. It also has putative analgesic and antiinfl ammatory properties that stem from its antioxidant properties. Research is examining the use of piperine in treating malaria. Antiepilepsirine is a derivative of piperine that is used to treat different types of epilepsy, especially in China. A current area of interest is the efficacy of piperine in increasing the bioavailability of certain nutrients and drugs. It is thought to possibly aid digestion and increase the absorption in the digestive tract of numerous drugs used as cancer treatments, antihistamines, steroidal inflammation reducers, and antibiotics.

Uses

The alkaloid which gives pepper its spiciness, and has been used as an organic insecticide.

Uses

analeptic, antibacterial

Uses

antipsychotic

Uses

A black pepper extract TRPV1 activator

Safety Profile

Poison by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Piperine crystallises as light yellow crystals from EtOH or EtOAc (m 132o), aqueous EtOH (m 128-129o), Et2O (m129o), or*benzene/ligroin. [Beilstein 20 H 79, 20 I 23, 20 II 53, 20 III/IV 1341, 20/3 V 469.]

Piperine Preparation Products And Raw materials

Raw materials

Preparation Products


Piperine Suppliers

Global( 233)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19954 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2238 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2982 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20243 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19997 58

View Lastest Price from Piperine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-24 Piperine
94-62-2
US $1.00 / kg 1g 99% 100KG career henan chemical co
2018-10-10 Hot sale Piperine 90%min CAS NO.94-62-2
94-62-2
US $1.00 / G 100G 99.9% 50000 tons Hebei Ruishun Trade Co.,Ltd

Piperine Spectrum


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