3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
- CAS No.
- 198474-05-4
- Chemical Name:
- 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
- Synonyms
- EOS200271;PF-06840003;EOS200271 PF-06840003;PF-06840003 (racemate);PF 06840003;PF-06840003;PF-06840003 (EOS-200271);3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione;3-(5-Fluoro-1H-indol-3-yl)-2,5-pyrrolidinedione;3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione;2,5-Pyrrolidinedione, 3-(5-fluoro-1H-indol-3-yl)-
- CBNumber:
- CB12523559
- Molecular Formula:
- C12H9FN2O2
- Molecular Weight:
- 232.21
- MDL Number:
- MFCD25121820
- MOL File:
- 198474-05-4.mol
| Melting point | 190-195 °C |
|---|---|
| Boiling point | 533.2±50.0 °C(Predicted) |
| Density | 1.464±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) |
| form | solid |
| pka | 9.13±0.50(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| FDA UNII | 5K1FUI0T2C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25003 | EOS200271 ≥98% | 198474-05-4 | 5mg | $26 | 2024-03-01 | Buy |
| Cayman Chemical | 25003 | EOS200271 ≥98% | 198474-05-4 | 1mg | $39 | 2023-01-06 | Buy |
| Cayman Chemical | 25003 | EOS200271 ≥98% | 198474-05-4 | 10mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 25003 | EOS200271 ≥98% | 198474-05-4 | 25mg | $90 | 2024-03-01 | Buy |
| TRC | P293790 | PF-06840003 | 198474-05-4 | 100mg | $90 | 2021-12-16 | Buy |
3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione Chemical Properties,Uses,Production
Description
PF-06840003 (198474-05-4) is a potent (IC50?= 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1?In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2?PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3
Uses
PF-06840003 is a potential clinical candidate as a novel and selective Indoleamine 2,3-dioxygenase inhibitor. Highly selective and orally bioavailable IDO-1 inhibitor.
References
1) Crosignani?et al.?(2017),?Discovery of a Novel and Selective Indoleamine-2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EROS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate;?J. Med. Chem.?60?9617 2) Gomes?et al.?(2018),?Characterization of the Selective Indoleamine-2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy;?Mol. Cancer Ther.?9?2530 3) Blair?et al.?(2019),?IDO1 inhibition potentiates vaccine-induced immunity against pancreatic adenocarcinoma;?J. Clin. Invest.?129?1742
3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12431 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19639 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
View Lastest Price from 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-26 | 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
198474-05-4
|
US $1.00 / KG | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co |
-
- 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
198474-05-4
- US $1.00 / KG
- 97%-99.9%
- Career Henan Chemical Co