A 419259 trihydrochloride
- CAS No.
- 364042-47-7
- Chemical Name:
- A 419259 trihydrochloride
- Synonyms
- A419259;RK20449;RK-20449;RK 20449;A-419259;A 419259;A-419259 HCl;A 419259 trihydrochloride;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-;7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- CBNumber:
- CB12535657
- Molecular Formula:
- C29H34N6O
- Molecular Weight:
- 482.62
- MDL Number:
- MFCD28155266
- MOL File:
- 364042-47-7.mol
- MSDS File:
- SDS
A 419259 trihydrochloride price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0446 | A-419259 trihydrochloride ≥98% (HPLC) | 364042-47-7 | 5mg | $207 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0446 | A-419259 trihydrochloride ≥98% (HPLC) | 364042-47-7 | 25mg | $870 | 2024-03-01 | Buy |
| Cayman Chemical | 25605 | A-419259 ≥98% | 364042-47-7 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 25605 | A-419259 ≥98% | 364042-47-7 | 500μg | $35 | 2021-12-16 | Buy |
| Cayman Chemical | 25605 | A-419259 ≥98% | 364042-47-7 | 5mg | $199 | 2024-03-01 | Buy |
A 419259 trihydrochloride Chemical Properties,Uses,Production
Description
A-419259 is an inhibitor of Src family kinases, including Src, LCK, Lyn, and Hck (IC50s = 9, <3, <3, and 11.26 nM, respectively)., It is selective for these kinases over c-Abl (IC50 = 3,000 nM) and PKC (IC50 = >33 μM). A-419259 inhibits growth of Philadelphia chromosome-positive (Ph+) K-562 and Meg-01 myeloid leukemia cells (IC50s = 0.1-0.3 and 0.1 μM, respectively), but not Ph- TF-1 and HEL cells. It induces apoptosis in K-562 cells in a concentration-dependent manner. A-419259 (300 nM) inhibits differentiation of murine embryonic stem cells while maintaining pluripotency. It reduces the total number of acute myeloid leukemia (AML) cells, as well as AML stem cells, in the bone marrow and spleen in mouse patient-derived xenograft (PDX) models of AML when administered at a dose of 30 mg/kg twice daily.
Uses
A 419259 Trihydrochloride is the hydrochloride form of A 419259 which is a Src kinase inhibitor and can be used in treatment of chronic myelogenous leukemia, lymphangioleiomyomatosis and tuberous sclerosis.
A 419259 trihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
A 419259 trihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3419 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 | sale1@shzysw.net | China | 9763 | 58 |