JZL 184
- CAS No.
- 1101854-58-3
- Chemical Name:
- JZL 184
- Synonyms
- CS-815;CS-1861;JZL 184;JZL-184; JZL 184;JZL 184 JZL184 JZL-184;JZL184 (with 15% inorganics);MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem;4-Nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)Methyl]-1-piperidinecarboxylate;4-Nitrophenyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate;4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester
- CBNumber:
- CB12535677
- Molecular Formula:
- C27H24N2O9
- Molecular Weight:
- 520.49
- MDL Number:
- MOL File:
- 1101854-58-3.mol
- MSDS File:
- SDS
| Melting point | 116-120°C |
|---|---|
| Boiling point | 706.4±60.0 °C(Predicted) |
| Density | 1.467±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | White to off-white solid |
| pka | 13.32±0.29(Predicted) |
| color | light yellow to yellow-green |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months |
| CAS DataBase Reference | 1101854-58-3 |
| FDA UNII | 7MZ1I2J68A |
JZL 184 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 475741 | MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem The MAGL Inhibitor III, JZL184, also referenced under CAS 1101854-58-3, controls the biological activity of MAGL. |
1101854-58-3 | 10mg | $159 | 2024-03-01 | Buy |
| Sigma-Aldrich | J3455 | JZL 184 hydrate ≥97% (HPLC) | 1101854-58-3 | 5MG | $170 | 2023-06-20 | Buy |
| Cayman Chemical | 13158 | JZL 184 ≥97% | 1101854-58-3 | 5mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 13158 | JZL 184 ≥97% | 1101854-58-3 | 10mg | $74 | 2024-03-01 | Buy |
| Cayman Chemical | 13158 | JZL 184 ≥97% | 1101854-58-3 | 50mg | $299 | 2024-03-01 | Buy |
JZL 184 Chemical Properties,Uses,Production
Description
Endocannabinoids such as 2-
Uses
JZL184 is a strong and selective inhibitor of Monoglyceride Lipase.
Uses
JZL 184 hydrate has been used as an inhibitor of monoacylglycerol lipase to study its effect on human osteoblast differentiation and proliferation and postsynaptic neurons.
Definition
ChEBI: 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]-1-piperidinecarboxylic acid (4-nitrophenyl) ester is a member of benzodioxoles.
Biochem/physiol Actions
JZL184 selectively inhibits MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). Anandamide and 2-AG are the two endogenous endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Anandamide is predominantly metabolized by fatty acid amide hydrolase (FAAH), whereas monoacylglycerol lipase (MAGL) is thought to be the enzyme primarily responsible for the degradation of 2-AG. It is difficult to separate the activities of the two because most currently available inhibitors of MAGL are not selective, and also inhibit FAAH or other enzymes. JZL 184 is the first selective inhibitor of MAGL with nanomolar portency and over 200-fold selectivity for MAGL vs FAAH. When administered to mice, JZL184 increased levels of 2-arachidonoylglycerol in the brain by about 8-fold, with no effect on levels of anandamide.
storage
Store at -20°C
References
1) Long et al. (2009), Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects; Nat. Chem. Biol.,5 37 2) Pan et al. (2009), Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxyl)methyl)piperidine-1-carboxylate (JZL 184) enhances retrograde endocannabinoid signaling; J. Pharmacol. Exp. Ther., 331 591 3) Kinsey et al. (2009), Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain; J. Pharmacol. Exp. Ther., 330 902
JZL 184 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
