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ChemicalBook >> CAS DataBase List >>1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)

1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)

1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) Structure
1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) structure
CAS No.
140681-55-6
Chemical Name:
1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)
Synonyms
Selectfluor;Selectfluoro;1-(chloroMethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diiuM;selectfluor fluorinating reagent;1-(ChloroMethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diiuM tetrafluoroborate;selectfluor fluorinating;SELECTFLUOR I;1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane ditetrafluoroborate;Selecetfluor;fluorinating reagent
CBNumber:
CB1254109
Molecular Formula:
C7H14B2ClF9N2
Molecular Weight:
354.26
MDL Number:
MFCD00142607
MOL File:
140681-55-6.mol
MSDS File:
SDS
Last updated:2024-03-07 16:58:36
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1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) Properties

Melting point 260 °C(lit.)
Density 1.71 at 20℃
vapor pressure 0.001Pa at 25℃
storage temp. 2-8°C
solubility Acetonitrile (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated), Water
form Powder
color White
Water Solubility soluble
Sensitive Moisture Sensitive
Merck 14,8425
BRN 5368649
InChIKey ZQGDSZPGKPJABN-UHFFFAOYSA-N
LogP -3.39 at 20℃
Surface tension 73.1mN/m at 1g/L and 19℃
CAS DataBase Reference 140681-55-6(CAS DataBase Reference)
FDA UNII 4P1ZA6R76D
EPA Substance Registry System 1,4-Diazoniabicyclo[2.2.2]octane, 1-(chloromethyl)-4-fluoro-, bis[tetrafluoroborate(1-)] (140681-55-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H317-H318-H412
Precautionary statements  P261-P273-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn,O,F,Xi
Risk Statements  22-36/37/38-41-52/53-43
Safety Statements  26-36/37/39-61-21
RIDADR  UN 3088 4.2/PG 2
WGK Germany  2
Hazard Note  Oxidising Agent
TSCA  T
HazardClass  8
PackingGroup  II
HS Code  29335990
Toxicity LD50 in male rats: 640 mg/kg orally; >2 g/kg dermally (Banks, 1998)
NFPA 704
0
2 0

1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 439479 Selectfluor? fluorinating reagent >95% in F+ active 140681-55-6 5g $40.1 2024-03-01 Buy
Sigma-Aldrich 439479 Selectfluor? fluorinating reagent >95% in F+ active 140681-55-6 25g $119 2024-03-01 Buy
TCI Chemical F0358 N-Fluoro-N'-(chloromethyl)triethylenediamine Bis(tetrafluoroborate) >95.0%(T) 140681-55-6 5g $32 2024-03-01 Buy
TCI Chemical F0358 N-Fluoro-N'-(chloromethyl)triethylenediamine Bis(tetrafluoroborate) >95.0%(T) 140681-55-6 25g $94 2024-03-01 Buy
Alfa Aesar L17003 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), 98+% 140681-55-6 5g $55.5 2024-03-01 Buy
Product number Packaging Price Buy
439479 5g $40.1 Buy
439479 25g $119 Buy
F0358 5g $32 Buy
F0358 25g $94 Buy
L17003 5g $55.5 Buy

1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) Chemical Properties,Uses,Production

Tetrafluoroborate

1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), with the formula C7H14B2ClF9N2, is a selective fluorine reagent which is white crystal at room temperature. It is mainly used asfluorinating agent to make single fluoridation with electronic double bond, silyl enol ether and enol lithium salt and so on. It can be used in the preparation of fluorinated steroid drugs, etc.

Reaction

1. It is one of the most efficient and popular reagents for electrophilic fluorination. The product is also useful as a reagent, or catalyst, for oxidative transformations, coupling reactions and halogenations.
2. Useful for the direct electrophilic fluorination of ketones, ketals and enamides.
3. Ritter-type C-H amination of unactivated sp3. Reactions of 140681-55-6

Main Usage

It is mainly used as fluorinating agent to make single fluoridation with electronic double bond, silyl enol ether and enol lithium salt and so on. It can be used in the preparation of fluorinated steroid drugs, etc.

Description

1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)(Selectfluor) is a white solid (mp 190 °C), stable in air and to moisture. It is a dicationic salt soluble in cold water or dilute hydrochloric acid. However, it decomposes in dilute sodium hydroxide and reacts with cold DMSO (rapidly and exothermally) and with DMF (slowly on heating). It is moderately soluble in acetonitrile but only slightly soluble in lower alcohols and acetone, which makes the former the solvent of choice. Occasionally, reactions in these solvents were accelerated by adding a small amount of water or trifluoroacetic acid. Bulk quantities of Selectfluor should be stored in a cool, dry place and not heated above 80 °C. Fainzil’berg et al. have measured the reduction potentials of Selectfluor and other N-F compounds. With a positive reduction potential, E1/2 ) 0.33 V, Selectfluor is predicted to be a more reactive fluorinating reagent than, e.g., N-fluorobenzenesulfonimide, with E1/2 ) -1.24 V[1].

Chemical Properties

White powder

Uses

Effective electrophilic fluorinating reagent for a wide variety of substrates such as aromatics, alkenes, carbohydrates, etc.

Uses

Mild, versatile fluorinating reagent used in pharmaceutical and agricultural applications.

General Description

This product is a fluorine donor also called Selectfluor and has been enhanced for catalysis.

Toxicology

1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (F-TEDA-BF4) is moderately toxic (male rat oral LD50 640 mg kg?1; female rat 350–500 mg kg?1), and is an irritant to the eye and respiratory system. Always use approved dust mask (or respirator), gloves, and safety glasses when handling the solid. Carry out solubility tests on a sensible scale when seeking alternative solvents (note the problem with DMSO referred to above).

Advantages

As the advantages of non-toxicity, non-corrosion and chemical stability, 1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) have been widely used in industry and public life.

References

[1] Rajendra P. Singh, Jean’ne M. Shreeve. “Recent Highlights in Electrophilic Fluorination with 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane Bis(tetrafluoroborate).” ChemInform 35 16 (2004).

1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) Preparation Products And Raw materials

Raw materials

Fluorine

Preparation Products

PyriMidine, 2-[4-(1-piperazinyl)phenyl]-

1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) Suppliers

Global( 369)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Didu New Materials Co. Ltd 		+86-89586680 +86-13289823923 1026@dideu.com China 9116 58
Shandong Juchuang Chemical Co., LTD 		+86-18885615001 +86-18885615001 admin@juchuangchem.com China 387 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Fluoropharm Co., Ltd. 		+86-0571-85586753; +8613336034509 sales@fluoropharm.com China 1290 60
Zjartschem 		+86-571-8723 8903 jocelynpan@zjarts.com jocelynpan@zjarts.com CHINA 993 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Tianjin Huiren Chemtech Co., Ltd 		+86-86-22-23707858 +86-86-13672008665 huirentech@foxmail.com China 169 58
Supplier Advantage
Shaanxi Didu New Materials Co. Ltd 		58
Shandong Juchuang Chemical Co., LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Fluoropharm Co., Ltd. 		60
Zjartschem 		58
career henan chemical co 		58
Tianjin Huiren Chemtech Co., Ltd 		58

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View Lastest Price from 1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) pictures 2024-03-11 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)
140681-55-6
 US $50.00-20.00 / kg 500kg 99.9 200tons Shandong Juchuang Chemical Co., LTD
-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) pictures 2023-10-21 -Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)
140681-55-6
 US $0.00 / kg 25kg 99.0% 20mt Shaanxi Didu New Materials Co. Ltd
1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) pictures 2022-10-10 1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)
140681-55-6
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) Spectrum

1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)(140681-55-6)IR11-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)(140681-55-6)IR2

140681-55-6(1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate))Related Search:

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1of4

N-FLUORO-N'-(CHLOROMETHYL)TRIETHYLENEDIAMINE BIS(TETRAFLUOROBORATE) N-CHLOROMETHYL-N'-FLUOROTRIETHYLENEDIAMMONIUM BIS (TETRAFLUOROBORATE) SELECTFLUOR F-TEDA-BF4 SELECTFLUOR(R) REAGENT SELECTFLUOR(TM) FLUORINATING REAGENT 1-CHLOROMETHYL-4-FLUORO-1,4-DIAZONIABICYCLO[2.2.2]OCTANE BIS f-teda-bf_4 4-(chloromethyl)-1-fluoro-1,4-diazoniabicyclo[2,2,2]octane tetrafluoroboron N-Fluoro-N'-chloromethyltriethylenediamine 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), 98+% F-TEDA, 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), N-Chloromethyl-Nμ-fluorotriethylenediammonium bis(tetrafluoroborate) Selectfluor(R) fluorinating reagent F-TEDA, N-Chloromethyl-Nμ-fluorotriethylenediammonium bis(tetrafluoroborate) 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo2.2.2 aoctane bis(tetrafluoroborate), 96% 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo2.2.2üoctane bis(tetrafluoroborate), 98+% 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate),96% 1-chloromethy 1-4-fluoro-1, 4-diazoniabicyclo〔2.2.2〕octanebis(tetrafluoroborate) 1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]oc F-TEDA F-TEDA-BF4 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) N-Chloromethyl-N′-fluorotriethylenediammonium bis(tetrafluoroborate) 1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo Selectfluor (Air Prods. Chem.) 4-diazoniabicyclo[2.2.2]octane,1-(chloromethyl)-4-fluoro-bis[tetrafluorobo 4-diazoniabicyclo[2.2.2]octane,1-(chloromethyl)-4-fluoro-bis[tetrafluoroborate(1-)] rate(1-)] 1-CHLOROMETHYL-4-FLUORO-1,4-DIAZONIABICYCLO[2.2.2]OCTANE BIS(TETRAFLUOROBORATE) N-Fluoro-N'-chloromethyltriethylenediaminebis(tetrafluoroborate)(SELECTFLUORTM) 1-chlorome.-4-fluoro-1,4-diazoniabicyclo octane bis(bf4) F-TEDA-BF_4~SELECTFLUOR(rg Fluorinating 1-CHLOROME.-4-FLUORO-1,4-DIAZONIABICYCLO SELECTFLUOR FLUORINATING REAGENT, >95% F + ACTIVE Selectfluor fluorinating reagent,1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), N-Chloromethyl-N′-fluorotriethylenediammonium bis(tetrafluoroborate), F-TEDA 2-(chloroMethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diiuM diboranuide 1-CHLOROMETHYL-4-FLUORO-1,4-DIAZONIABICYCLO[2.2.2]OCTANE BIS(TETRAFLUOROB+) T 1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane Bis(tetrafluoroborate) F-TEDA-BF4 Selectfluor® N-Fluoro-N-chloroMethyltriethylenediaMine bis(tetrafluoroborate), (Selectfluor) 1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]oCLane bis(tetrafluoroborate) 1,4-Diazoniabicyclo2.2.2octane, 1-(chloromethyl)-4-fluoro-, bistetrafluoroborate(1-) 1-CHLOROMETHYL-4-FLUOR-1,4-DIAZONIABICYCLO 2.2.2. OCTANE BIS (TETRAFLUOROBORATE) 1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane FTB Selectfluor Selectfluor(R) fluorinating reagent >95% in F+ active 1-ChloroMethyl-4-fluoro-1,4-1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), 96% 1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), min. 97% SelectFluor(R) 1-(CHLOROMETHYL)-4-FLUORO-1,4-DIAZABICYCLO[2.2.2]OCTANE-1,4-DIIUM; BIS(TETRAFLUOROBORANUIDE) bis(tetrafluoroboranuide) 1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), min. 97% SelectFluor SELECTFLUOR(TM) o[2.2.2]octane bis(tetrafL uoro-1,4-diazoniabicycL [tris(λ2-fluoranidyl)-λ1-boranetriiumyl]-λ2-fluoranide 4-(chloromethyl)-1-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)(SelectFluor) N-Fluoro-N'-(chloromethyl)triethylenediamineBis(tetrafluoroborate)> SELECTFLUOR FLUORINATING REAGENT (Selectfluor) 1,4-Diazoniabicyclo[2.2.2]octane, 1-(chloromethyl)-4-fluoro-, tetrafluoroborate(1-) (1:2) 1- Chloromethyl-4-fluoro-1, 4-diazabicyclic [2.2.2] octane bis (tetrafluoroborate) salt