CCT241533
- CAS No.
- 1262849-73-9
- Chemical Name:
- CCT241533
- Synonyms
- CS-198;CCT241533;CCT241533 (CCT 241533;4-Fluoro-2-(4-(((3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl)amino)-6,7-dimethoxyquinazolin-2-yl)phenol;3-Pyrrolidinemethanol, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-, (3R,4S)-;(3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-alpha,alpha-dimethyl-3-pyrrolidinemethanol
- CBNumber:
- CB12570371
- Molecular Formula:
- C23H27FN4O4
- Molecular Weight:
- 442.4832832
- MDL Number:
- MFCD22417095
- MOL File:
- 1262849-73-9.mol
- MSDS File:
- SDS
| Boiling point | 569.4±50.0 °C(Predicted) |
|---|---|
| Density | 1.327 |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | crystalline solid |
| pka | 8.18±0.48(Predicted) |
| FDA UNII | 79D8PWX59X |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
CCT241533 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C227905 | CCT241533 | 1262849-73-9 | 50mg | $815 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611866 | CCT241533 >98% | 1262849-73-9 | 50mg | $994.5 | 2021-12-16 | Buy |
| ApexBio Technology | A3291 | CCT241533 | 1262849-73-9 | 50mg | $1559 | 2021-12-16 | Buy |
| ApexBio Technology | A3291 | CCT241533 | 1262849-73-9 | 2mg | $134 | 2021-12-16 | Buy |
| ApexBio Technology | A3291 | CCT241533 | 1262849-73-9 | 5mg | $202 | 2021-12-16 | Buy |
CCT241533 Chemical Properties,Uses,Production
Uses
CCT241533 is an inhibitor of checkpoint kinase 2, which is a potential antitumor and radioprotectant.
Biological Activity
chk2 is a checkpoint kinase involved in the atm-mediated response to double-strand dna breaks. inhibitors of chk2 may increase the efficacy of genotoxic cancer therapies. cct241533 has been identified and characterized as a novel chk2 kinase inhibitor.in silico: x-ray crystallography confirmed that cct241533 bound to chk2 in the atp pocket. overall, the binding mode was found to be very highly conserved relative to previous compounds, with all of the key hydrogen bond interactions maintained. the potency gained with cct241533 therefore appears to be due to the presence of the two methoxy substituents occupying the solvent exposed region of the enzyme, and contributions from the isopropyl alcohol substituent, which may participate in a second intramolecular hydrogen bond to the quinazoline exocyclicnh [2].
in vitro
cct241533 inhibits chk2 with an ic50 of 3 nmol/l and shows minimal cross-reactivity against a panel of kinases at 1 mmol/l. cct241533 did not potentiate the cytotoxicity of a selection of genotoxic agents in several cell lines [1]. moreover, as the most potent chk2 inhibitor identified in the series, cct241533 shows potent selectivity (63-fold) over chk1 and low herg inhibition (hergic50=22 μm) [2].
References
[1] anderson ve, walton mi, eve pd, boxall kj, antoni l, caldwell jj, aherne w, pearl lh, oliver aw, collins i, garrett md. cct241533 is a potent and selective inhibitor of chk2 that potentiates the cytotoxicity of parp inhibitors. cancer res. 2011;71(2):463-72.
[2] caldwell jj, welsh ej, matijssen c, anderson ve, antoni l, boxall k, urban f, hayes a, raynaud fi, rigoreau lj, raynham t, aherne gw, pearl lh, oliver aw, garrett md, collins i. structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. j med chem. 2011;54(2):580-90.
CCT241533 Preparation Products And Raw materials
Raw materials
Preparation Products
CCT241533 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 | |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7893 | 56 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
