ChemicalBook
Chinese Japanese Germany Korea

GABEXATE

GABEXATE
GABEXATE structure
CAS No.
39492-01-8
Chemical Name:
GABEXATE
Synonyms
GABEXATE;Gabexate USP/EP/BP;GabexateMesylateBase;4-[(6-Guanidinohexanoyl)oxy]benzoic acid ethyl ester;diaminomethylidene-[6-(4-ethoxycarbonylphenoxy)-6-oxohexyl]ammonium;4-[[6-[[Amino(imino)methyl]amino]-1-oxohexyl]oxy]benzoic acid ethyl ester;Benzoic acid, 4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethylester;[N'-[5-(4-ethoxycarbonylphenoxy)carbonylpentyl]carbamimidoyl]azanium methanesulfonate
CBNumber:
CB1258637
Molecular Formula:
C16H23N3O4
Formula Weight:
321.37
MOL File:
39492-01-8.mol

GABEXATE Properties

Boiling point:
472.2±55.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
Desiccate at RT
pka
13.83±0.70(Predicted)
FDA UNII
4V7M9137X9

GABEXATE price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC G122803 Gabexate mesylate 39492-01-8 10mg $50 2021-12-16 Buy
AK Scientific 8132AH Gabexate 39492-01-8 100mg $144 2021-12-16 Buy
American Custom Chemicals Corporation API0002787 GABEXATE 95.00% 39492-01-8 50MG $976.27 2021-12-16 Buy
Medical Isotopes, Inc. 18645 Gabexate 39492-01-8 25 mg $1500 2021-12-16 Buy
AvaChem 2815B Gabexate 39492-01-8 1g $245 2021-12-16 Buy

GABEXATE Chemical Properties,Uses,Production

Originator

Gabexate Mesylate,Shangai Lansheng

Uses

Gabexate mesylate is used in combination with somatostatin and octreotide in the treatment of severe acute pancreatitis in elderly patients.

Manufacturing Process

Guanidinocaproic acid p-tosyl salt and thionyl chloride were mixed together to react at the room temperature. An endothermic reaction occurred and the caproic acid gradually dissolved. Then the reaction mixture was left standing for 1 to 2 h and was extracted with ether. The lower oily layer and the ether layer were separated from each other and the lower layer was repeatedly washed with ether. Then the oily substance (caproic acid chloride) was added with benzoic acid ethyl ester in tetrahydrofuran, and the mixture was stirred. After the mixture became a uniform solution, of pyridine were gradually added. An exothermic reaction occurred and an oily substance came to be separated in the lower layer. After the completion of the reaction, the oily substance was washed with water and then recrystallized from hot water once or twice. Thus 4-(6-guanidino-hexanoyloxy)-benzoic acid ethyl ester salt was obtained as white crystals.
To obtained the base 4-(6-guanidino-hexanoyloxy)-benzoic acid ethyl ester the 4-(6-guanidino-hexanoyloxy)-benzoic acid ethyl ester salt must be treated by, for example, sodium hydroxide.
In practice it is usually used as mesylate.

Therapeutic Function

Enzyme inhibitor

Biological Activity

Serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC 50 values are 9.4, 30, 41 and 110 mM respectively). Antithrombotic in vitro and in vivo . Also inhibits LPS-induced TNF- α production, probably by inhibiting NF- κ B and AP-1 activation.

GABEXATE Preparation Products And Raw materials

Raw materials

Preparation Products


GABEXATE Suppliers

Global( 29)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd
18192627656
+86-29-88380327 1012@dideu.com CHINA 3949 58
Career Henan Chemica Co
15093356674 0371-55982848
0371-86658258 laboratory@coreychem.com CHINA 30290 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9938 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30014 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 132148 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 821-50328103-801
86-21-50328109 3bsc@sina.com China 15877 69
BOC Sciences 16314854226
info@bocsci.com United States 21113 65
9ding chemical ( Shanghai) Limited 4009209199
86-021-52271987 sales@9dingchem.com China 18226 56
EMMX Biotechnology LLC 888-539-0666
888-539-0666 info@emmx.com United States 8454 60
UHN Shanghai Research & Development Co., Ltd. 18930822973 021-58958002-
021-58958618 xiaoyangw@gmail.com;xiaoyangw@gmail.com China 1920 58

View Lastest Price from GABEXATE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-04 Gabexate USP/EP/BP
US $1.10 / g 1g 0.999 100 Tons min Dideu Industries Group Limited
2020-03-16 Gabexate mesylate
39492-01-8
US $1.00-0.00 / KG 1KG 99% 10000KG Shaanxi Dideu Medichem Co. Ltd

39492-01-8(GABEXATE)Related Search:


  • GABEXATE
  • GabexateMesylateBase
  • [N'-[5-(4-ethoxycarbonylphenoxy)carbonylpentyl]carbamimidoyl]azanium methanesulfonate
  • 4-[(6-Guanidinohexanoyl)oxy]benzoic acid ethyl ester
  • 4-[[6-[[Amino(imino)methyl]amino]-1-oxohexyl]oxy]benzoic acid ethyl ester
  • diaminomethylidene-[6-(4-ethoxycarbonylphenoxy)-6-oxohexyl]ammonium
  • Benzoic acid, 4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethylester
  • Gabexate USP/EP/BP
  • 39492-01-8
  • Proteinase-activated receptor (PAR)
Copyright 2017 © ChemicalBook. All rights reserved