DWK-1339
- CAS No.
- 1018946-38-7
- Chemical Name:
- DWK-1339
- Synonyms
- SNU-0039;DWK-1339;SNU-0039 (DWK-133);DWK-1339;DWK 1339;DWK1339;2-(3,4-dimethoxyphenyl)-5-(3-methoxypropyl)-1-benzofuran;Benzofuran, 2-(3,4-diMethoxyphenyl)-5-(3-Methoxypropyl)-;2-(3,4-DiMethoxy-phenyl)-5-(3-Methoxy-propyl)-benzofuran;MDR1339,DWK1339,inhibit,β-amyloid peptide,Inhibitor,MDR 1339,Abeta,Amyloid-β,MDR-1339,DWK 1339
- CBNumber:
- CB12627783
- Molecular Formula:
- C20H22O4
- Molecular Weight:
- 326.39
- MDL Number:
- MFCD22665705
- MOL File:
- 1018946-38-7.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMF: 30mg/mL; DMSO: 30mg/mL; Ethanol: 2mg/mL |
| form | A crystalline solid |
| FDA UNII | WN8TEM4Q1F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
DWK-1339 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27642 | DWK-1339 | 1018946-38-7 | 500μg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 27642 | DWK-1339 | 1018946-38-7 | 5mg | $722 | 2024-03-01 | Buy |
| Cayman Chemical | 27642 | DWK-1339 | 1018946-38-7 | 1mg | $230 | 2024-03-01 | Buy |
| TRC | D103595 | DWK-1339 | 1018946-38-7 | 1mg | $275 | 2021-12-16 | Buy |
| ChemScene | CS-0003407 | MDR-1339 98.03% | 1018946-38-7 | 25mg | $560 | 2021-12-16 | Buy |
DWK-1339 Chemical Properties,Uses,Production
Description
DWK-1339 is an inhibitor of amyloid-β (Aβ) aggregation. It inhibits aggregation of monomeric Aβ (1-42) (Aβ42) and induces disaggregation of Aβ42 fibrils in vitro when used at concentrations ranging from 3.1 to 50 μM. DWK-1339 (10 μM) reduces Aβ42-induced toxicity in HT-22 cells. In vivo, DWK-1339 (10 mg/kg) increases step-through latency in a passive avoidance test and increases spontaneous alteration in the Y-maze compared with vehicle control mice in a mouse model of Aβ42-induced acute Alzheimer''s disease. It also decreases brain levels of Aβ42 and increases spontaneous alteration in the Y-maze in the APP/PS1 transgenic mouse model of Alzheimer''s disease.
Uses
DWK-1339, is an orally active and blood-brain-barrier-permeable Aβ-aggregation inhibitor, used in the research of Alzheimer''s disease.
DWK-1339 Preparation Products And Raw materials
Raw materials
Preparation Products
DWK-1339 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Xi'an Manareco New Materials Co., Ltd. | 029-02968669089-8816 | market@xarlm.com | China | 438 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| Guangzhou Zhiya Chemdrugs Co.,Ltd | 18122150900 | sculk28@163.com | China | 647 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1831 | 55 |
| Suzhou Ran enzyme Biotechnology Co., Ltd. | 0512-0512-62793604 18015430729 | 116667374@qq.com | China | 117 | 58 |