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ELR-510444

ELR-510444 structure

CAS No.: 1233948-35-0

Chemical Name:: ELR-510444

Synonyms: CS-1765;LR-510444;ELR-510444;ELR510444, >95%;ELR-510444;ELR510444;N-[5-(5-Cyano-2-thienyl)-2-methylphenyl]-4-methylbenzenesulfonamide;Benzenesulfonamide, N-[5-(5-cyano-2-thienyl)-2-methylphenyl]-4-methyl-;N-(5-(5-cyanothiophen-2-yl)-2-Methylphenyl)-4-MethylbenzenesulfonaMide;N-(5-(5-cyanothiophen-2-yl)-2-methylphenyl)-4-methylbenzenesulfonamide ELR-510444

CBNumber:: CB12627798

Molecular Formula:: C19H16N2O2S2

Molecular Weight:: 368.47

MDL Number:: MFCD25976813

MOL File:: 1233948-35-0.mol

MSDS File:: SDS

Last updated:2023-06-08 09:02:20

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ELR-510444 Properties

Boiling point	547.8±60.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in H2O; insoluble in EtOH; ≥11.9 mg/mL in DMSO
form	solid
pka	8.28±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P260-P280-P303+P361+P353-P301+P330+P331-P304+P340+P310-P305+P351+P338+P310

NFPA 704

	0
2		0

ELR-510444 price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	17696	ELR510444 ≥95%	1233948-35-0	1mg	$44	2024-03-01	Buy
Cayman Chemical	17696	ELR510444 ≥95%	1233948-35-0	5mg	$161	2024-03-01	Buy
Cayman Chemical	17696	ELR510444 ≥95%	1233948-35-0	10mg	$257	2024-03-01	Buy
Cayman Chemical	17696	ELR510444 ≥95%	1233948-35-0	25mg	$479	2024-03-01	Buy
AK Scientific	8445DG	N-(5-(5-Cyanothiophen-2-yl)-2-methylphenyl)-4-methylbenzenesulfonamide	1233948-35-0	25mg	$631	2021-12-16	Buy

Product number	Packaging	Price	Buy
17696	1mg	$44	Buy
17696	5mg	$161	Buy
17696	10mg	$257	Buy
17696	25mg	$479	Buy
8445DG	25mg	$631	Buy

ELR-510444 Chemical Properties,Uses,Production

Description

ELR510444 is an inhibitor of tubulin polymerization (IC₅₀ = 10 μM) that binds to tubulin at the colchicine binding site. It induces microtubule depolymerization in A-10 cells (EC₅₀ = 21 nM). ELR510444 inhibits growth in a cancer cell line panel (IC₅₀s = 9-43 nM) via formation of multiple spindles and induction of mitotic arrest. Oral administration of ELR510444 (3-6 mg/kg) reduces tumor size in an MDA-MB-231 breast cancer mouse xenograft model in a dose-dependent manner. ELR510444 also inhibits hypoxia-inducible factor 1α (HIF-1α) in RCC4 cells in a concentration-dependent manner.

in vitro

elr510444 has potent microtubuledisrupting activity, causing a loss of intracellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. elr510444 inhibited cell proliferation, inhibited the rate and extent of purified tubulin assembly potently, and displaced colchicine from tubulin, revealing that the drug directly interacts with tubulin at the colchicine-binding site [1].

in vivo

elr510444 also shows potent antitumor activity in the mda-mb-231 xenograft model with at least a 2-fold therapeutic window [1].

References

[1] risinger al, westbrook cd, encinas a, mülbaier m, schultes cm, wawro s, lewis jd, janssen b, giles fj, mooberry sl. elr510444, a novel microtubule disruptor with multiple mechanisms of action. j pharmacol exp ther. 2011 mar;336(3):652-60.

ELR-510444 Preparation Products And Raw materials

Raw materials

Preparation Products

ELR-510444 Suppliers

Global( 84)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9991	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Shenzhen Shengda Pharma Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58

View Lastest Price from ELR-510444 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-09-06	N-(5-(5-cyanothiophen-2-yl)-2-Methylphenyl)-4-MethylbenzenesulfonaMide 1233948-35-0	US $1.00 / KG	1KG	98%	20kg	Career Henan Chemical Co

N-(5-(5-cyanothiophen-2-yl)-2-Methylphenyl)-4-MethylbenzenesulfonaMide
1233948-35-0
US $1.00 / KG
98%
Career Henan Chemical Co

ELR-510444 Spectrum

ELR-510444(1233948-35-0)MS

N-(5-(5-cyanothiophen-2-yl)-2-Methylphenyl)-4-MethylbenzenesulfonaMide N-(5-(5-cyanothiophen-2-yl)-2-methylphenyl)-4-methylbenzenesulfonamide ELR-510444 LR-510444 N-[5-(5-Cyano-2-thienyl)-2-methylphenyl]-4-methylbenzenesulfonamide ELR-510444 CS-1765 ELR-510444;ELR510444 ELR510444, >95% Benzenesulfonamide, N-[5-(5-cyano-2-thienyl)-2-methylphenyl]-4-methyl- 1233948-35-0 API Inhibitors