4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
- CAS No.
- 1197377-47-1
- Chemical Name:
- 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
- Synonyms
- (3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile;4-(3-AMINO-1,2,4-TRIAZIN-6-YL)-2-FLUOROBENZONITRILE;Benzonitrile, 4-(3-amino-1,2,4-triazin-6-yl)-2-fluoro-
- CBNumber:
- CB12652323
- Molecular Formula:
- C10H6FN5
- Molecular Weight:
- 215.19
- MDL Number:
- MFCD24642894
- MOL File:
- 1197377-47-1.mol
- MSDS File:
- SDS
Boiling point | 497.4±55.0 °C(Predicted) |
---|---|
Density | 1.46±0.1 g/cm3 (20 ºC 760 Torr) |
pka | 2?+-.0.63(Predicted) |
InChI | InChI=1S/C10H6FN5/c11-8-3-6(1-2-7(8)4-12)9-5-14-10(13)16-15-9/h1-3,5H,(H2,13,14,16) |
InChIKey | JXQHTMHBDHVPDQ-UHFFFAOYSA-N |
SMILES | C(#N)C1=CC=C(C2N=NC(N)=NC=2)C=C1F |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H317 |
Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0101071 | 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile 97.05% | 1197377-47-1 | 100mg | $80 | 2021-12-16 | Buy |
ChemScene | CS-0101071 | 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile 97.05% | 1197377-47-1 | 250mg | $120 | 2021-12-16 | Buy |
AK Scientific | 2209AQ | 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile | 1197377-47-1 | 250mg | $244.4 | 2021-12-16 | Buy |
ChemScene | CS-0101071 | 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile 97.05% | 1197377-47-1 | 1g | $250 | 2021-12-16 | Buy |
ChemScene | CS-0101071 | 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile 97.05% | 1197377-47-1 | 5g | $750 | 2021-12-16 | Buy |
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile Chemical Properties,Uses,Production
Uses
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile is a useful research chemical compound used in the preparation of salts of [(quinolinylmethyl)imidazotriazinyl]benzamide as tyrosine kinase inhibitors useful in the treatment of diseases.
Synthesis
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile could be synthesize from the reaction of 6-bromo-1,2,4-triazin-3-amine with 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile. A solution concluding these two compounds in 1,4-dioxane (1200 mL) was stirred before K2CO3 was added. The reaction mixture was degassed by bubbling with nitrogen before 1,1'-bis(diphenyl phosphine)ferrocene dichloropalladium(II) complex with dichloromethane (1:1) (Pd(dppf)2Cl2 was added. The resulting reaction mixture was degassed by bubbling with nitrogen and then heated at 86° C. After the reaction mixture was cooled to 0-5° C. 1,4-Dioxane was added before aqueous hydrochloric acid solution was added dropwise to adjust pH to 0.40-0.93. The mixture was stirred at for 30 min and filtered. The solid collected was stirred with 1,4-dioxane, and HCl added. Finally, after purification, product 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile was obtained.
Solubility in organics
Very soluble in N,N-Dimethylformamide,Soluble in methanol,Sparingly soluble inglacial acetic acid, Very slightly soluble inchloroform, Practically insoluble in water.
storage
Keep in dark place,Inert atmosphere,Room temperature
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Suzhou Ryan Pharmachem Technology Co.,Ltd. | +86-512-68780025 +8618962125825 | sales@ryanchem.com | China | 137 | 58 |
Zison Pharmaceutical (Shandong) Co., Ltd. | +86-0086-531-88259693 +86-18660188356 | maguanglei@zisonpharm.com | China | 53 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7933 | 58 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
CR Corporation Lomited | fred.wen@crcorporation.cn | CHINA | 12069 | 58 | |
Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5905 | 58 |
View Lastest Price from 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2023-12-29 | 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
1197377-47-1
|
US $101.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | ||
2023-12-21 | 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
1197377-47-1
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd | ||
2023-12-01 | 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
1197377-47-1
|
US $0.00-0.00 / kg | 1kg | ≥98% by HPLC | 100kg/month | Zison Pharmaceutical (Shandong) Co., Ltd. |
- 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
1197377-47-1
- US $101.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
- 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
1197377-47-1
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
- 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
1197377-47-1
- US $0.00-0.00 / kg
- ≥98% by HPLC
- Zison Pharmaceutical (Shandong) Co., Ltd.