6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine
- CAS No.
- 1262888-28-7
- Chemical Name:
- 6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine
- Synonyms
- C43;CS-1649;Spautin-1;SPAUTIN-1;SPAUTIN1;Spautin 1 - MBCQ derivative C43;4-((4-Fluorobenzyl)amino)-6-fluoroquinazoline;6-Fluoro-N-(4-fluorobenzyl)-4-quinazolinamine;6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine;6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine 98+%;6-Fluoro-N-[(4-fluorophenyl)methyl]quinazolin-4-amine
- CBNumber:
- CB12658835
- Molecular Formula:
- C15H11F2N3
- Molecular Weight:
- 271.26
- MDL Number:
- MFCD16962292
- MOL File:
- 1262888-28-7.mol
- MSDS File:
- SDS
Melting point | 211 °C |
---|---|
Boiling point | 419.6±40.0 °C(Predicted) |
Density | 1.366±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: soluble15mg/mL (clear solution) |
pka | 5.75±0.50(Predicted) |
form | powder |
color | white to beige |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05,GHS07 |
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Signal word | Danger | |||||||||
Hazard statements | H302-H318 | |||||||||
Precautionary statements | P280-P301+P312+P330-P305+P351+P338+P310 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 22-41 | |||||||||
Safety Statements | 26-39 | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 2922390090 | |||||||||
NFPA 704 |
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6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine price More Price(39)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0440 | Spautin-1 ≥98% (HPLC) | 1262888-28-7 | 5mg | $127 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0440 | Spautin-1 ≥98% (HPLC) | 1262888-28-7 | 25mg | $202 | 2024-03-01 | Buy |
TCI Chemical | P2613 | Spautin-1 | 1262888-28-7 | 10MG | $162 | 2024-03-01 | Buy |
TCI Chemical | P2613 | Spautin-1 | 1262888-28-7 | 50MG | $560 | 2024-03-01 | Buy |
Cayman Chemical | 17769 | Spautin-1 ≥95% | 1262888-28-7 | 1mg | $32 | 2024-03-01 | Buy |
6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine Chemical Properties,Uses,Production
Description
Spautin-1 (1262888-28-7) is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes.1?Deranges dengue virion maturation.2?Spautin-1 inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells.3?Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency.4?Cell permeable.
Uses
Spautin-1 is a potent pharmacological autophagy inhibitor that promotes UVB-induced tumorigenesis. It is also a small-molecule drug that modulate autophagic pathways in different types of cancer.
Uses
Spautin-1 has been used as an autophagy inhibitor:
- to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model
- to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin
- to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay
Biochem/physiol Actions
Spautin-1 inhibits the activity of two ubiquitin-specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy.
in vitro
spautin-1 promotes the degradation of vps34 pi3 kinase complexes via inhibiting two ubiquitinspecific peptidases, usp10 and usp13, that target the beclin1 subunit of vps34 complexes. spautin-1 had no effect on the growth and survival of bcap-37 cells under normal culture conditions but dramatically enhanced cell death in glucose-free media. under glucose-free conditions, western blotting for lc3 further confirmed that autophagy was induced, which was inhibited by spautin-1. similar results were obtained with mcf-7 and bt549 cells. therefore, spautin-1 can sensitize tumor cells to apoptosis under nutritional deprived conditions [1].
IC 50
0.6 and 0.7 μm for usp10 and usp13 activity, respectively
storage
Store at +4°C
References
1) Liu et al. (2011), Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13; Cell, 147 223 2) Mateo et al. (2013), Inhibition of cellular autophagy deranges dengue virion maturation; J. Virol., 87 1312 3) Correa et al. (2014), Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability; Carcinogenesis,?35 1951 4) Vakifahmetoglu-Norburg et al. (1987), Chaperone-mediated autophagy degrades mutant p53; Genes Dev., 27 1718
6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Aceschem Inc. | +1-817863-6948 +1-(817)863-6948 | sales@aceschem.com | United States | 19639 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40068 | 58 |