5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)
- CAS No.
- 852391-15-2
- Chemical Name:
- 5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)
- Synonyms
- Nec-1s;CS-2815;7-Cl-O-Nec1;Nec-1s(7-Cl-O-Nec1);Necrostatin-2 raceMate;Necrostatin 2 (raceMate);Necrostatin 2 racemate (Nec-1s);RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem;5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione);5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione
- CBNumber:
- CB12662775
- Molecular Formula:
- C13H12ClN3O2
- Molecular Weight:
- 277.71
- MDL Number:
- MFCD19443135
- MOL File:
- 852391-15-2.mol
- MSDS File:
- SDS
| Melting point | 173-175℃ |
|---|---|
| Density | 1.450±0.06 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | Off-white to pale yellow solid |
| pka | 8.48±0.70(Predicted) |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.04297 | RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem | 852391-15-2 | 10mg | $258 | 2023-01-07 | Buy |
| Cayman Chemical | 20924 | (±)-Necrostatin-2 ≥98% | 852391-15-2 | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 20924 | (±)-Necrostatin-2 ≥98% | 852391-15-2 | 5mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 20924 | (±)-Necrostatin-2 ≥98% | 852391-15-2 | 10mg | $216 | 2024-03-01 | Buy |
| AK Scientific | 8960CC | Necrostatin2racemate | 852391-15-2 | 5mg | $221 | 2021-12-16 | Buy |
5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) Chemical Properties,Uses,Production
Description
7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50?= 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2?7-Cl-O-Nec1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4?7-Cl-O-Nec1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50?= 210 nM vs. EC50?= 490 nM), no non-specific cytotoxicity at high concentrations (100 μM) and reasonable pharmacokinetic characteristics when used in mice.2?7-Cl-O-Nec1 is recommended for cellular and?in vivo?use over Necrostatin-1.5
Uses
Necrostatin 1s is an inhibitor of indolamine 2,3-deoxygenase. Necrostatin 1s is a neuroprotective with potential therapeutic functions against brain ischemia.
References
1) Degterev?et al. (2005)?Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury; Nat. Chem. Biol.,?1?112 2) Teng?et al. (2005)?Structure-activity relationship of novel necroptosis inhibitors; Bioorg. Med. Chem. Lett.,?15?5039 3) Degterev?et al. (2012)?Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase; Cell Death Differ.,?20?366 4) Takahashi?et al. (2012)?Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models; Cell Death Dis.,?3?e437 5) Degterev?et al. (2013)?Addendum: Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury; Nat. Chem. Biol.,?9?192
5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3419 | 58 |