ChemicalBook >> CAS DataBase List >>3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)-

3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)-

3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)- structure

CAS No.: 1402709-93-6

Chemical Name:: 3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)-

Synonyms: CS-2683;CCT241736;CCT241736, 10 mM in DMSO;CCT241736;CCT-241736;CCT 241736;6-Chloro-7-(4-(4-chlorobenzyl)piperazin-1-yl)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-b]pyridine;6-chloro-7-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridine;1-[6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-7-yl]-4-[(4-chlorophenyl)methyl]piperazine;3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)-;CCT 241736,Fms like tyrosine kinase 3,CCT241736,CD135,Inhibitor,FLT3,CCT-241736,Aurora Kinase,Cluster of differentiation antigen 135,inhibit

CBNumber:: CB12668045

Molecular Formula:: C22H23Cl2N7

Molecular Weight:: 456.37

MDL Number:: MFCD25977004

MOL File:: 1402709-93-6.mol

Last updated:2025-04-18 09:51:41

Product description	Number	Pack Size	Price
CCT241736	26185	5mg	$81
CCT241736	26185	10mg	$129
CCT241736	26185	25mg	$298
CCT241736	26185	50mg	$553
CCT241736 99.86%	CS-0007372	100mg	$720
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3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)- Properties

storage temp.	Store at -20°C
solubility	DMSO:75.0(Max Conc. mg/mL);164.34(Max Conc. mM)
form	A crystalline solid
color	White to off-white
FDA UNII	ZE94SP78UG

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)- price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	26185	CCT241736	1402709-93-6	5mg	$81	2024-03-01	Buy
Cayman Chemical	26185	CCT241736	1402709-93-6	10mg	$129	2024-03-01	Buy
Cayman Chemical	26185	CCT241736	1402709-93-6	25mg	$298	2024-03-01	Buy
Cayman Chemical	26185	CCT241736	1402709-93-6	50mg	$553	2024-03-01	Buy
ChemScene	CS-0007372	CCT241736 99.86%	1402709-93-6	100mg	$720	2021-12-16	Buy

Product number	Packaging	Price	Buy
26185	5mg	$81	Buy
26185	10mg	$129	Buy
26185	25mg	$298	Buy
26185	50mg	$553	Buy
CS-0007372	100mg	$720	Buy

3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)- Chemical Properties,Uses,Production

Uses

CCT241736 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor, which inhibits Aurora kinases (Aurora-A Kd, 7.5 nM, IC50, 38 nM; Aurora-B Kd, 48 nM), FLT3 kinase (Kd, 6.2 nM), and FLT3 mutants including FLT3-ITD (Kd, 38 nM) and FLT3(D835Y) (Kd, 14 nM).

in vivo

CCT241736 (50, 100 mg/kg, b.i.d, p.o.) dose-dependently suppresses the growth of MV4-11 human tumor xenografts, and completely abolishes the tumors at 100 mg/kg via p.o. administration twice a day^[1].

IC 50

Aurora-A: 38 nM (IC₅₀); Aurora-A: 7.5 nM (Kd); Aurora-B: 48 nM (Kd); FLT3(K663Q): 5.1 nM (Kd); FLT3: 6.2 nM (Kd); FLT3(D835H): 11 nM (Kd); FLT3(D835Y): 14 nM (Kd); FLT3(N841I): 16 nM (Kd); FLT3-ITD: 38 nM (Kd); FLT3(R834Q): 110 nM (Kd)

References

[1] Bavetsias V, et al. Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia. J Med Chem. 2012 Oct 25;55(20):8721-34. DOI:10.1021/jm300952s

3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)- Suppliers

Global( 44)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39035	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	12952	65
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4759	55
BOC Sciences	16314854226	info@bocsci.com	United States	9923	65
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62
Shanghai Chaolan Chemical Technology Center	021-QQ：65489617 15618227136	Sales@ATKchemical.com	China	9118	58
Twochem Co.Ltd.	021-58111628 15800915896	sales@twochem.com	China	1788	58
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Taizhou Crene Biotechnology Co. Ltd.	+86-0576-88813233 +86-13396860566	sales@pharm-intermediates.com	China	1991	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
BOC Sciences	65
Shanghai Lollane Biological Technology Co.,Ltd.	55
BOC Sciences	65
ShangHai Biochempartner Co.,Ltd	62
Shanghai Chaolan Chemical Technology Center	58
Twochem Co.Ltd.	58
Fan De(Beijing) Biotechnology Co., Ltd.	58
Taizhou Crene Biotechnology Co. Ltd.	58

3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)- Spectrum

3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)-(1402709-93-6)¹HNMR

1402709-93-6(3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)-)Related Search:

CCT196969 N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide CCT245737

3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)- 6-chloro-7-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridine CCT241736 CCT241736;CCT-241736;CCT 241736 CS-2683 6-Chloro-7-(4-(4-chlorobenzyl)piperazin-1-yl)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-b]pyridine CCT 241736,Fms like tyrosine kinase 3,CCT241736,CD135,Inhibitor,FLT3,CCT-241736,Aurora Kinase,Cluster of differentiation antigen 135,inhibit 1-[6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-7-yl]-4-[(4-chlorophenyl)methyl]piperazine CCT241736, 10 mM in DMSO 1402709-93-6 C22H23Cl2N7 API