SR9011
- CAS No.
- 1379686-29-9
- Chemical Name:
- SR9011
- Synonyms
- SR9001;SR9011;CS-2028;SR-90011;SR-9011;SR 9011;Stenabolic Sr9011;SR9011 Sarms powder;SR-9011;SR 9011;SR9011;White Powder SR9011Cas# 1379686-29-9 Raw Chemical Material;Trifunctional Methacrylate Monomer Sarm Steroids Powder Sr9011
- CBNumber:
- CB12672925
- Molecular Formula:
- C23H31ClN4O3S
- Molecular Weight:
- 479.04
- MDL Number:
- MFCD29472235
- MOL File:
- 1379686-29-9.mol
| Boiling point | 642.8±50.0 °C(Predicted) |
|---|---|
| Density | 1.254±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 14.71±0.40(Predicted) |
| color | Dark Yellow to Very Dark Brown |
| InChI | InChI=1S/C23H31ClN4O3S/c1-2-3-4-12-25-23(29)27-13-11-19(16-27)15-26(14-18-5-7-20(24)8-6-18)17-21-9-10-22(32-21)28(30)31/h5-10,19H,2-4,11-17H2,1H3,(H,25,29) |
| InChIKey | PPUYOYQTTWJTIU-UHFFFAOYSA-N |
| SMILES | N1(C(NCCCCC)=O)CCC(CN(CC2=CC=C(Cl)C=C2)CC2SC([N+]([O-])=O)=CC=2)C1 |
| FDA UNII | VYI79FLZ6W |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
SR9011 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11930 | SR 9011 ≥98% | 1379686-29-9 | 1mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 11930 | SR 9011 ≥98% | 1379686-29-9 | 5mg | $384 | 2024-03-01 | Buy |
| TRC | S684260 | SR9011 | 1379686-29-9 | 25mg | $2180 | 2021-12-16 | Buy |
| AK Scientific | 4689DN | SR-9011 | 1379686-29-9 | 5mg | $525 | 2021-12-16 | Buy |
| ApexBio Technology | B1768 | SR9011 | 1379686-29-9 | 2mg | $126 | 2021-12-16 | Buy |
SR9011 Chemical Properties,Uses,Production
Biochem/physiol Actions
SR9011 is a potent nuclear receptor REV-ERB agonist (EC50 of REV-ERBα- and REV-ERBβ-dependent repressor activity = 790 and 560 nM, respectively, by cell-based reporter assay) that stimulates REV-ERB-dependent target genes suppression both in cultures in vitro and in mice in vivo (100 mg/kg i.p., b.i.d.) without activity toward a panel of 46 other nuclear receptors. SR9011 is shown to modulate circadian behavior by suppressing the transcription factors BMAL1 (brain and muscle ARNT-like protein 1) and CLOCK (circadian locomotor output cycles kaput) as well as induce energy expenditure and weight loss by regulating genes involved in lipid and glucose metabolism in mice in vivo with good bioavailabiilty (plasma conc. = 0.53 and 15.3 μM 2 hr post 10 or 100 mg/kg i.p. dosage; brain conc. = 0.24 μM 2 hr post 10 mg/kg i.p.), while its structure analog GSK4112 shows no plasma exposure.
Uses
SR 9011 is a synthetic REV-ERBα/β agonist with activity in vivo. It is a lead compound for a new class of cancer drugs associated with the body’s circadian clock.
Application
SR9011 has been used as a nuclear receptor subfamily 1 group D member 1 (NR1D1) receptor agonist:
to study its effects on microglial immune-metabolism
to study its effects on insulin secretion from human type 2 diabetes islet cells
to study its effects on thyroid-stimulating hormone β (TSHβ) gene expression
SR9011 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 | market02@senwayer.com | China | 874 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 436 | 58 |
| Hebei Anlijie Biotechnology Co., Ltd | +8619031013551 | ably@aljbio.com | China | 177 | 58 |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1100 | 58 |
| Wuhan Ruichi Technology Co., Ltd | +8613545065237 | admin@whrchem.com | China | 164 | 58 |
| Shanghai Aosiris new Material Technology Co., LTD | 86-15139564871 +8615139564871 | wrjmoon2000@163.com | China | 354 | 58 |
| Guangdong Tuoyuan Biotechnology Co., LTD | +85267545345 | sterodschina@gmail.com | China | 115 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Dorne Chemical Technology co. LTD | +86-13583358881 +86-18560316533 | Ethan@dornechem.com | China | 294 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 | salesvip2@hntmhg.com | China | 415 | 58 |
Related articles
- The Breakthrough of SR9011 in Chemical Research: A New Dawn for Biological Clock Studies
- The discovery of SR9011 marks a new era in our understanding of the biological clock and its mechanisms for disease treatment.
- Apr 10，2024
- SR9011: Synthesis, Detection and Bioactivity
- SR9011 is a REV-ERBα/β agonist, a member of the nuclear receptor family.
- Nov 29，2022
View Lastest Price from SR9011 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | SR9011
1379686-29-9
|
US $30.00 / Box | 1Box | 99.99% | 10000000000 | zhuzhou dingcheng meihei comestic co.,ltd | |
 |
2024-04-24 | SR9011
1379686-29-9
|
US $1.00 / g | 1g | 99% | 100kg | Dorne Chemical Technology co. LTD | |
 |
2024-04-24 | SR9011
1379686-29-9
|
US $9.90-17337.00 / g | 1g | 99% | 100kg | Wuhan Cell Pharmaceutical Co., Ltd |