Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>KPT-330

KPT-330

KPT-330 Structure
KPT-330 structure
CAS No.
1393477-72-9
Chemical Name:
KPT-330
Synonyms
Selinexor;Xpovio;KPT-330;CS-1056;Aloradine;KPT330; KPT 330;KPT330,Selinexor;KPT-330 USP/EP/BP;Selinexor (KPT-330);Selinexor free base
CBNumber:
CB12681123
Molecular Formula:
C17H11F6N7O
Molecular Weight:
443.31
MDL Number:
MFCD27987944
MOL File:
1393477-72-9.mol
Last updated:2024-01-23 15:27:11
Request For Quotation

KPT-330 Properties

Density 1.55±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (up to at least 25 mg/ml). or in Ethanol (up to at least 25 mg/ml)
pka 9.74±0.43(Predicted)
form solid
color Off-white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
NCI Dictionary of Cancer Terms selinexor
FDA UNII 31TZ62FO8F
NCI Drug Dictionary selinexor
ATC code L01XX66

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H332-H302-H312
Precautionary statements  P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501

KPT-330 price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18127 KPT-330 ≥98% 1393477-72-9 1mg $29 2021-12-16 Buy
Cayman Chemical 18127 KPT-330 ≥98% 1393477-72-9 5mg $94 2021-12-16 Buy
Cayman Chemical 18127 KPT-330 ≥98% 1393477-72-9 10mg $160 2021-12-16 Buy
Cayman Chemical 18127 KPT-330 ≥98% 1393477-72-9 50mg $508 2021-12-16 Buy
Biorbyt Ltd orb180928 KPT-330(Selinexor) >98% 1393477-72-9 100mg $765 2021-12-16 Buy
Product number Packaging Price Buy
18127 1mg $29 Buy
18127 5mg $94 Buy
18127 10mg $160 Buy
18127 50mg $508 Buy
orb180928 100mg $765 Buy

KPT-330 Chemical Properties,Uses,Production

Description

Selinexor (1393477-72-9) is a potent inhibitor of the nuclear export receptor, chromosome region maintenance 1 (CRM1; Exportin-1 (XPO1)). It exhibited potent growth suppression in various T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50’s = 34-203 nM)1?and pancreatic cancer cells (IC50?~ 150 nM)2. Selinexor is being investigated as a possible chemotherapeutic in treating multiple types of cancer.3-8?Currently in clinical trials.

Uses

KPT 330 is a chromosome maintenance protein 1 (CRM1) inhibitor. KPT 330 suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.

storage

Store at -20°C

References

1) Etchin?et al.?(2013),?KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-ALL and AML; Br. J. Haematol.?161?117 2) Azmi?et al. (2013),?Selective Inhibitors of Nuclear Export Block Pancreatic Cancer Cell Proliferation and Reduce Tumor Growth in Mice; Gastroenterology?144?447 3) Desisto?et al.?(2019),?Exportin 1 inhibition induces nerve growth factor receptor expression to inhibit the NF-kB pathway in preclinical models of pediatric high-grade glioma; Mol. Cancer Ther.?19 540 4) Aboukameel?et al. (2018),?Down-regulation of AR splice variants through XPO1 suppression contributes to the inhibition of prostate cancer progression;?Oncotarget?9?35327 5) Baek?et al.?(2018),?XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies; Oncotarget?9?34567 6) Wahba?et al.?(2018),?The XPO1 Inhibitor Selinexor Inhibits Translation and Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and In Vivo; Mol. Cancer Ther.?17?1717 7) Arango?et al.?(2017),?Selinexor (KPT-330) demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer; Breast Cancer Res.?19?93 8) Conforti?et al.?(2017),?Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors; Cancer Res.?77?5614

KPT-330 synthesis

1388842-44-1
54608-52-5
1393477-72-9
Synthesis of KPT-330 from (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid and 2-Hydrazinopyrazine

KPT-330 Preparation Products And Raw materials

Raw materials

3,5-Bis(trifluoromethyl)benzonitrile 2-Hydrazinopyrazine 3,5-DI(TRIFLUOROMETHYL)BENZENE-1-CARBOTHIOAMIDE (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid 3,5-Di(trifluoromethyl)benzamide
(Z)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

1of2

Preparation Products

3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazole

KPT-330 Suppliers

Global( 149)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ICH Biofarm Co., Ltd 		+undefined8613073685410 sales@ichemie.com China 985 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29220 58
Wuhan Nutra Biotechnology Co.,Ltd 		+8617786394783 nutrabiotech@outlook.com China 300 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9427 58
Supplier Advantage
Hangzhou ICH Biofarm Co., Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
Wuhan Nutra Biotechnology Co.,Ltd 		58
Baoji Guokang Healthchem co.,ltd 		58

Related articles

View Lastest Price from KPT-330 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Selinexor pictures 2023-11-01 Selinexor
1393477-72-9
 US $0.00-0.00 / KG 1KG 99% 200 Hangzhou ICH Biofarm Co., Ltd
Selinexor;KPT-330 pictures 2021-10-08 Selinexor;KPT-330
1393477-72-9
 US $0.00-0.00 / g 1g 98%+ 100kgs Wuhan Nutra Biotechnology Co.,Ltd
KPT-330 pictures 2019-07-06 KPT-330
1393477-72-9
 US $1.00 / KG 1G 98% 100KG Career Henan Chemical Co
  • Selinexor pictures
  • Selinexor
    1393477-72-9
  • US $0.00-0.00 / KG
  • 99%
  • Hangzhou ICH Biofarm Co., Ltd
  • KPT-330 pictures
  • KPT-330
    1393477-72-9
  • US $1.00 / KG
  • 98%
  • Career Henan Chemical Co

KPT-330 Spectrum

KPT-330(1393477-72-9)MSKPT-330(1393477-72-9)1HNMR

1393477-72-9(KPT-330)Related Search:

PD 173074 KPT-330, (E)-RN Verdinexor (KPT-335) Bortezomib (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-
MK-2206 2HCl OTX015 KPT-185 Ruxolitinib CONCANAMYCIN A
Prostaglandin E2 SGC-GAK-1 2-BROMOHEXADECANOIC ACID 3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazole (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid
2-Propenoic acid, 3-iodo-, 1-methylethyl ester, (2Z)- (Z)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

1of4

KPT-330 (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide Selinexor (KPT-330) (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide 2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2Z)- Aloradine KPT330,Selinexor (KPT330)(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide SELINEXOR;KPT330;KPT 330 KPT-330,Selinexor, >98% KPT330; KPT 330 CS-1056 (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide(Selinexor) Selinexor free base KPT-330 USP/EP/BP Selinexor Selinexor (KPT 330),Selinexor (KPT330) Avatrombopag Impurity 32 Hydrochloride Xpovio (Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide 1393477-72-9 C17H11F6N7O Inhibitors API