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p-Trifluoromethoxy phenol

p-Trifluoromethoxy phenol structure

CAS No.: 828-27-3

Chemical Name:: p-Trifluoromethoxy phenol

Synonyms: 4-(TRIFLUOROMETHOXY)PHENOL;TFMOPO;uoromethoxy)phenoL;TIMTEC-BB SBB006554;p-Trifluoromethoxy p;4-trifluoroMethoxylphenol;p-(Triflourmethoxy)phenol;P-(TRIFLUOROMETHOXY)PHENOL;PHENOL,4-(TRIFLUOROMETHOXY);4-(TrifluorMethoxy)benzolol

CBNumber:: CB1268120

Molecular Formula:: C7H5F3O2

Molecular Weight:: 178.11

MDL Number:: MFCD00040988

MOL File:: 828-27-3.mol

MSDS File:: SDS

Last updated:2026-01-13 11:14:39

Product description	Number	Pack Size	Price
4-(Trifluoromethoxy)phenol 98%	339865	1g	$24
4-(Trifluoromethoxy)phenol 98%	339865	5g	$43
4-(Trifluoromethoxy)phenol >95.0%(GC)	T1341	5g	$21
4-(Trifluoromethoxy)phenol >95.0%(GC)	T1341	25g	$29
4-(Trifluoromethoxy)phenol	T790885	100g	$475
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p-Trifluoromethoxy phenol Properties

Melting point	17-18°C
Boiling point	92 °C25 mm Hg(lit.)
Density	1.375 g/mL at 25 °C(lit.)
refractive index	n20/D 1.447(lit.)
Flash point	187 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform, Methanol
pka	9.30±0.13(Predicted)
form	Liquid
Specific Gravity	1.375
color	Clear brown
BRN	1945934
InChI	1S/C7H5F3O2/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4,11H
InChIKey	NWVVVBRKAWDGAB-UHFFFAOYSA-N
SMILES	Oc1ccc(OC(F)(F)F)cc1
CAS DataBase Reference	828-27-3(CAS DataBase Reference)
NIST Chemistry Reference	Phenol, 4-(trifluoromethoxy)-(828-27-3)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06

Signal word

Danger

Hazard statements

H301-H314-H412

Precautionary statements

P270-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,Xi

Risk Statements

20/21/22-36/37/38

Safety Statements

26-27-36/37/39

RIDADR

2927

WGK Germany

Hazard Note

Irritant

HazardClass

6.1

PackingGroup

III

HS Code

29095090

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 3 Oral
Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1B

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	2
3		1

p-Trifluoromethoxy phenol price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	339865	4-(Trifluoromethoxy)phenol 98%	828-27-3	1g	$24	2023-01-07	Buy
Sigma-Aldrich	339865	4-(Trifluoromethoxy)phenol 98%	828-27-3	5g	$43	2023-01-07	Buy
TCI Chemical	T1341	4-(Trifluoromethoxy)phenol >95.0%(GC)	828-27-3	5g	$21	2025-07-31	Buy
TCI Chemical	T1341	4-(Trifluoromethoxy)phenol >95.0%(GC)	828-27-3	25g	$29	2025-07-31	Buy
TRC	T790885	4-(Trifluoromethoxy)phenol	828-27-3	100g	$475	2021-12-16	Buy

Product number	Packaging	Price	Buy
339865	1g	$24	Buy
339865	5g	$43	Buy
T1341	5g	$21	Buy
T1341	25g	$29	Buy
T790885	100g	$475	Buy

p-Trifluoromethoxy phenol Chemical Properties,Uses,Production

Uses

4-(Trifluoromethoxy)phenol is used as a reactant in the preparation of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors.

Chemical Properties

clear brown liquid

Uses

4-(Trifluoromethoxy)phenol was employed in the catalytic enantioselective synthesis of esters.

Uses

Intermediates of Liquid Crystals

Uses

4-(Trifluoromethoxy)phenol is used as a reactant in the preparation of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 25, p. 1097, 1982 DOI: 10.1021/jm00351a018

Synthesis

139301-27-2

828-27-3

General procedure for the synthesis of 4-trifluoromethoxyphenol from 4-trifluoromethoxyphenylboronic acid: In an atypical method, a flask containing 4-trifluoromethoxyphenylboronic acid (100 mg, 0.82 mmol) was taken to which 10 mol% of iron(III) oxide photocatalyst (13.1 mg) and tetrahydrofuran (2 ml) were added. The reaction mixture was stirred in a normal open flask under diffuse sunlight until complete consumption of the feedstock was shown by thin layer chromatography (TLC) detection. Upon completion of the reaction, the reaction was quenched with water and filtered to remove the catalyst. The filtrate was concentrated under vacuum. The crude product was purified by column chromatography on silica gel (100-200 mesh) with an eluent of 15:1 ethyl acetate/hexane, resulting in 73.2 mg (95% yield) of pure crystalline 4-trifluoromethoxyphenol.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 4, p. 811 - 814
[2] Tetrahedron Letters, 2015, vol. 55, # 4, p. 811 - 814
[3] Synthesis (Germany), 2014, vol. 46, # 3, p. 295 - 300

p-Trifluoromethoxy phenol synthesis

Synthesis of p-Trifluoromethoxy phenol from 4-Trifluoromethoxyphenylboronic acid

p-Trifluoromethoxy phenol Preparation Products And Raw materials

Raw materials

4,4,5,5-TETRAMETHYL-2-(4-TRIFLUOROMETHOXYPHENYL)-1,3,2-DIOXABOROLANE 4-(Trifluoromethoxy)aniline 4-Trifluoromethoxyphenylboronic acid Oxygen Tetrahydrofuran

Hematite

1of2

Preparation Products

2-AMINO-4-(TRIFLUOROMETHOXY)PHENOL N-Boc-3,4-dihydro-2H-pyridine 4-(TRIFLUOROMETHOXY)THIOPHENOL 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE 1-(4-(TRIFLUOROMETHOXY)PHENOXY)-4-(METHYLSULFONYL)BENZENE

p-Trifluoromethoxy phenol Suppliers

Global( 461)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20128	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Chongqing Soarwin Technology Co., Ltd	+86-15790943001	crystal@sorawin.cn	China	421	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13620	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21599	55
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Chongqing Soarwin Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Fluoropharm Co., Ltd.	60

View Lastest Price from p-Trifluoromethoxy phenol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-05	p-Trifluoromethoxy phenol 828-27-3	US $1.00 / kg	1kg	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2026-01-05	p-Trifluoromethoxy phenol 828-27-3	US $0.00-0.00 / KG	10mg	99%	2000tons	Shaanxi Dideu Medichem Co. Ltd
2025-12-01	4-(Trifluoromethoxy)phenol 828-27-3	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

p-Trifluoromethoxy phenol
828-27-3
US $1.00 / kg
99%
Hebei Chuanghai Biotechnology Co., Ltd

p-Trifluoromethoxy phenol
828-27-3
US $0.00-0.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

4-(Trifluoromethoxy)phenol
828-27-3
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

p-Trifluoromethoxy phenol Spectrum

p-Trifluoromethoxy phenol(828-27-3)¹HNMR p-Trifluoromethoxy phenol(828-27-3)FT-IR p-Trifluoromethoxy phenol(828-27-3)IR p-Trifluoromethoxy phenol(828-27-3)Raman

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PHENOL,4-(TRIFLUOROMETHOXY) TFMOPO p-Trifluoromethoxy p 4-Hydroxy-alpha,alpha,alpha-trifluoroanisole 4-trifluoroMethoxylphenol 4-(TrifluoroMethoxy)phenol, 98% 1GR 4-TRIFLUOROMETHOXYPHENOL FOR SYNTHESIS 4-(TrifluorMethoxy)benzolol 4-(threeMethoxyphenolfluoride) 4-HYDROXYPHENYL TRIFLUOROMETHYL ETHER 4-HYDROXYTRIFLUOROMETHOXYBENZENE TIMTEC-BB SBB006554 P-(TRIFLUOROMETHOXY)PHENOL For trifluoromethoxy phenol p-Trifluoromethoxy Phenol 4-Trifluoromethoxy Phenol 4-(Trifluoromethoxy)phenol 98% 4-(Trifluoromethoxy)phenol98% p-(Triflourmethoxy)phenol uoromethoxy)phenoL 4-(trifluoromethoxy)phenole 4-(TRIFLUOROMETHOXY)PHENOL 828-27-3 828-27-1 CF3OC6H4OH C7H5F3O2 Phenols Oxygen Compounds Organic Building Blocks Building Blocks alcohol Trifluoro-methoxy-benzene series Phenol&Thiophenol&Mercaptan API intermediates Organic Building Blocks Oxygen Compounds Phenols Trifluoroanisole series Aromatic Hydrocarbons (substituted) & Derivatives Aromatic Phenols bc0001