ChemicalBook >> CAS DataBase List >>ACT-132577
ACT-132577
- CAS No.
- 1103522-45-7
- Chemical Name:
- ACT-132577
- Synonyms
- ACT-132577;Aprocitentan;Despropyl Macitentan;Macitentan ACT-132577;N-Despropyl Macitentan;Macitentan Impurity 07;Macitentan ACT-132577-D4;Macitentan N-Despropyl Impurity;Despropyl Macitentan (COLD SHIPMENT REQUIRED);APROCITENTAN; ACT-132577; ACT 132577; ACT132577; DESPROPYL MACITENTAN
- CBNumber:
- CB12685914
- Molecular Formula:
- C16H14Br2N6O4S
- Molecular Weight:
- 546.19
- MDL Number:
- MFCD28155267
- MOL File:
- 1103522-45-7.mol
- MSDS File:
- SDS
Last updated:2023-05-18 11:31:11
| Melting point | 139-141°C |
|---|---|
| Boiling point | 705.0±70.0 °C(Predicted) |
| Density | 1.841±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly, Heated), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 13.56±0.60(Predicted) |
| color | White to Off-White |
| FDA UNII | MZI81HV01P |
ACT-132577 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D297305 | N-DespropylMacitentan | 1103522-45-7 | 10mg | $580 | 2021-12-16 | Buy |
| TRC | D297305 | N-DespropylMacitentan | 1103522-45-7 | 5mg | $305 | 2021-12-16 | Buy |
| TRC | D297305 | N-DespropylMacitentan | 1103522-45-7 | 50mg | $1635 | 2021-12-16 | Buy |
| ChemScene | CS-2687 | Aprocitentan 98.13% | 1103522-45-7 | 100mg | $2520 | 2021-12-16 | Buy |
| ChemScene | CS-2687 | Aprocitentan 98.13% | 1103522-45-7 | 5mg | $420 | 2021-12-16 | Buy |
ACT-132577 Chemical Properties,Uses,Production
Uses
N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)
Definition
ChEBI: ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ether, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol.
ACT-132577 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 111)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| ENBRIDGE PHARMTECH CO., LTD. | +8613812269233 | tinayang@enbridgepharm.com | China | 303 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Jiangxi Huihe Chemical Co., Ltd. | +86-19189228086 +8618858568638 | wuzhouding@huihecrop.com | China | 886 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
N-Despropyl Macitentan
ACT-132577
N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]sulfamide
Aprocitentan
5-(4-BROMOPHENYL)-4-[2-(5-BROMOPYRIMIDIN-2-YL)OXYETHOXY]-6-(SULFAMOYLAMINO)PYRIMIDINE
APROCITENTAN; ACT-132577; ACT 132577; ACT132577; DESPROPYL MACITENTAN
Despropyl Macitentan
Sulfamide, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-
Macitentan N-Despropyl Impurity
N-[5-(4-bromophenyl)-6-[2-(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl
Macitentan ACT-132577
5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(sulfamoyl)pyrimidin-4-amine
Macitentan ACT-132577-D4
N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]aminosulfonamide
5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]-ethoxy]-4-pyrimidinyl]sulfamide
Macitentan Impurity 07
Despropyl Macitentan (COLD SHIPMENT REQUIRED)
N-(5-(4-Bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)sulfamide
1103522-45-7
C16H14Br2N6O4S
APIS