ChemicalBook >> CAS DataBase List >>PNU-159682
PNU-159682
- CAS No.
- 202350-68-3
- Chemical Name:
- PNU-159682
- Synonyms
- PNU-159682;PNU-159682 95%;PNU-159682 >95%; 5-hydroxy-6-tert.-butyl-1,1-pentamethylene-3,3-dimethyl-indane;inhibit,non-Hodgkin’s lymphoma,PNU159682,ADCs Toxin,PNU-159682,acute myeloid leukemia,ADC Payload,EDV nanocell,AML,Inhibitor,ADC Cytotoxin,PNU 159682,Topoisomerase,NMS249,NHL;(8S,10S)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-{[(2S,4R,6S,7S,9R,10S)-10-methoxy-6-methyl-5,8,11-trioxa-1-azatricyclo[7.4.0.02,?]tridecan-4-yl]oxy}-5,7,8,9,10,12-hexahydrotetracene-5,12-dione;(8S,10S)-6,8,11-Trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-(((1S,3R,4aS,9S,9aR,10aS)-9-methoxy-1-methyloctahydro-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl)oxy)-7,8,9,10-tetrahydrotetracene-5,12-dione;(8S,10S)-7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-5,12-naphthacenedione;5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-, (8S,10S)-
- CBNumber:
- CB12702958
- Molecular Formula:
- C32H35NO13
- Molecular Weight:
- 641.62
- MDL Number:
- MFCD12756329
- MOL File:
- 202350-68-3.mol
Last updated:2025-10-29 15:43:00
| Product description | Number | Pack Size | Price |
| PNU-159682 97.24% | CS-3298 | 5mg | $750 |
| PNU-159682 97.24% | CS-3298 | 10mg | $1000 |
| PNU-159682 97.24% | CS-3298 | 50mg | $2400 |
| PNU-159682 98+% | CD31002752 | 50mg | $3750 |
| PNU-159682 98+% | CD31002752 | 100mg | $6150 |
| Boiling point | 838.5±65.0 °C(Predicted) |
|---|---|
| Density | 1.58±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO: 2mg/mL, clear |
| pka | 7.34±0.60(Predicted) |
| form | Solid |
| color | Reddish Brown to red |
| InChIKey | SLURUCSFDHKXFR-WWMWMSKMSA-N |
| SMILES | C1(OC)=C2C(C(=O)C3=C(C2=O)C(O)=C2C(C[C@@](O)(C(CO)=O)C[C@@H]2O[C@@H]2O[C@@H](C)[C@@]4([H])O[C@@]5([H])N([C@@]4([H])C2)CCO[C@@H]5OC)=C3O)=CC=C1 |
| FDA UNII | CQ5A9ZNT7C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
PNU-159682 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-3298 | PNU-159682 97.24% | 202350-68-3 | 5mg | $750 | 2021-12-16 | Buy |
| ChemScene | CS-3298 | PNU-159682 97.24% | 202350-68-3 | 10mg | $1000 | 2021-12-16 | Buy |
| ChemScene | CS-3298 | PNU-159682 97.24% | 202350-68-3 | 50mg | $2400 | 2021-12-16 | Buy |
| Crysdot | CD31002752 | PNU-159682 98+% | 202350-68-3 | 50mg | $3750 | 2021-12-16 | Buy |
| Crysdot | CD31002752 | PNU-159682 98+% | 202350-68-3 | 100mg | $6150 | 2021-12-16 | Buy |
PNU-159682 Chemical Properties,Uses,Production
Characteristics
PNU-159682, a metabolite of the anthracycline neomycin metabolite, is a DNA topoisomerase I (TopoI) inhibitor with excellent cytotoxicity. It is a more potent and tolerable ADC cytotoxin than doxorubicin in ADC synthesis.
Uses
PNU-159682 can be used in EDV nanocell technology to overcome drug resistance.
Biological Activity
PNU-159682, an active nemorubicin metabolite, is a highly potent anthracycline toxin th at retains antitumor activity in vivo. Similarly to other anthracyclines PNU-159682 intercalates between the CG base pairs of DNA, but the stability of the complexes is much higher.
PNU-159682 Preparation Products And Raw materials
Raw materials
Preparation Products
PNU-159682 Suppliers
Global( 95)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| ChemExpress | +86-19370970350 +86-021-58950125 | info@chemexpress.com | China | 787 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 9942 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
View Lastest Price from PNU-159682 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-26 | PNU-159682
202350-68-3
|
US $84.00-363.00 / mg | 98.24% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-03-20 | PNU-159682
202350-68-3
|
US $10.00 / mg | 10mg | 95%+ | 500g | Wuhan Topule Biopharmaceutical Co., Ltd | |
 |
2020-02-14 | PNU-159682
202350-68-3
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- PNU-159682
202350-68-3
- US $84.00-363.00 / mg
- 98.24%
- TargetMol Chemicals Inc.
-
- PNU-159682
202350-68-3
- US $10.00 / mg
- 95%+
- Wuhan Topule Biopharmaceutical Co., Ltd
-
- PNU-159682
202350-68-3
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
PNU-159682
PNU-159682 >95%
PNU-159682 95%
(8S,10S)-7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-5,12-naphthacenedione
5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-, (8S,10S)-
5-hydroxy-6-tert.-butyl-1,1-pentamethylene-3,3-dimethyl-indane
inhibit,non-Hodgkin’s lymphoma,PNU159682,ADCs Toxin,PNU-159682,acute myeloid leukemia,ADC Payload,EDV nanocell,AML,Inhibitor,ADC Cytotoxin,PNU 159682,Topoisomerase,NMS249,NHL
(8S,10S)-6,8,11-Trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-(((1S,3R,4aS,9S,9aR,10aS)-9-methoxy-1-methyloctahydro-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl)oxy)-7,8,9,10-tetrahydrotetracene-5,12-dione
(8S,10S)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-{[(2S,4R,6S,7S,9R,10S)-10-methoxy-6-methyl-5,8,11-trioxa-1-azatricyclo[7.4.0.02,?]tridecan-4-yl]oxy}-5,7,8,9,10,12-hexahydrotetracene-5,12-dione
202350-68-3
