Sparsentan (RE-021)
- CAS No.
- 254740-64-2
- Chemical Name:
- Sparsentan (RE-021)
- Synonyms
- Sparsentan;RE-021;2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)benzenesulfonamide;RE 201;DARA-a;PS433540;Sparentan;BMS-346567;Sparsentan (RE-021);Sparsentan(PS433540)
- CBNumber:
- CB12707221
- Molecular Formula:
- C32H40N4O5S
- Molecular Weight:
- 592.75
- MDL Number:
- MFCD16628036
- MOL File:
- 254740-64-2.mol
| Melting point | 148 °C(Solv: isopropanol (67-63-0); water (7732-18-5)) |
|---|---|
| Boiling point | 744.4±70.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: soluble |
| form | A crystalline solid |
| pka | 7.06±0.50(Predicted) |
| InChIKey | WRFHGDPIDHPWIQ-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(CN3C(=O)C4(CCCC4)N=C3CCCC)C=C2COCC)=CC=CC=C1S(NC1C(C)=C(C)ON=1)(=O)=O |
| FDA UNII | 9242RO5URM |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Sparsentan (RE-021) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2808 | Sparsentan ≥98% (HPLC) | 254740-64-2 | 5MG | $85.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2808 | Sparsentan ≥98% (HPLC) | 254740-64-2 | 25MG | $352 | 2024-03-01 | Buy |
| TRC | R129300 | RE201 | 254740-64-2 | 1mg | $165 | 2021-12-16 | Buy |
| TRC | R129300 | RE201 | 254740-64-2 | 10mg | $1320 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 72248 | RE201 | 254740-64-2 | 10mg | $2200 | 2021-12-16 | Buy |
Sparsentan (RE-021) Chemical Properties,Uses,Production
Description
Sparsentan (PS-433540, RE-021, DARA) is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist.
Uses
RE 201 is used an Endothelin A receptor antagonist used in the treatment of hypertension.
Definition
Sparsentan (RE-021) is a selective dual-acting receptor antagonist with affinity for endothelin (A type) and angiotensin II receptors (Type 1). Sparsentan combines the active moieties of the selective AT1 receptor antagonist irbesartan and a selective ETA receptor antagonist.
Biological Activity
Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively.
in vitro
Sparsentan dose dependently antagonizes the angiotensin II-induced pressor response with an ED50 value of 0.8 μmol/kg iv and 3.6 μmol/kg po. Sparsentan also shows efficacious and long acting in the big ET-1-induced pressor model. Sparsentan causes a significant lowering of blood pressure at the lowest dose tested (10 μmol/kg/day) in spontaneously hypertensive rats. Sparsentan shows good oral bioavailability in rats, dogs, and monkeys, averaging 40%, 86%, and 21% F, respectively. At 100 μmol/kg/day, Sparsentan reduces the blood pressure from 170 to less than 100 mmHg during the course of the drug’s pharmacokinetic duration. Sparsentan at 100 μmol/kg/day essentially converts the spontaneously hypertensive rats into normotensive rats during the course of its pharmacokinetic duration.
Sparsentan (RE-021) Preparation Products And Raw materials
Raw materials
Preparation Products
Sparsentan (RE-021) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Ryan Pharmachem Technology Co.,Ltd. | +86-512-68780025 +8618962125825 | sales@ryanchem.com | China | 137 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 +86-15850508050 | sean.lv@synzest.com | China | 323 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
View Lastest Price from Sparsentan (RE-021) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-05-08 | Sparsentan
254740-64-2
|
US $0.00-0.00 / g | 100g | 98% | kg grade | Suzhou Ryan Pharmachem Technology Co.,Ltd. | |
 |
2020-01-10 | Sparsentan (RE-021)
254740-64-2
|
US $6.68 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- Sparsentan
254740-64-2
- US $0.00-0.00 / g
- 98%
- Suzhou Ryan Pharmachem Technology Co.,Ltd.
-
- Sparsentan (RE-021)
254740-64-2
- US $6.68 / KG
- 97%-99%
- Career Henan Chemical Co