ChemicalBook >> CAS DataBase List >>ESI 09
ESI 09
- CAS No.
- 263707-16-0
- Chemical Name:
- ESI 09
- Synonyms
- ESI09;ESI 09;ESI-09;Virus Protease,inhibit,ESI 09,ESI09,Inhibitor,ESI-09;2-(5-(tert-Butyl)isoxazol-3-yl)-N-(3-chlorophenyl)-2-oxoacetohydrazonoyl cyanide;(E)-2-(5-(tert-butyl)isoxazol-3-yl)-N-(3-chlorophenyl)-2-oxoacetohydrazonoyl cyanide;(E)-3-(5-tert-butylisoxazol-3-yl)-2-(2-(3-chlorophenyl)hydrazono)-3-oxopropanenitrile;alpha-[(3-Chlorophenyl)hydrazono]-5-(1,1-dimethylethyl)-beta-oxo-3-isoxazolepropanenitrile;α-[2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-b-oxo-3-isoxazolepropanenitrile;α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile
- CBNumber:
- CB12729362
- Molecular Formula:
- C16H15ClN4O2
- Molecular Weight:
- 330.77
- MDL Number:
- MFCD00109218
- MOL File:
- 263707-16-0.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
ESI 09 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0814 | ESI-09 ≥98% (HPLC) | 263707-16-0 | 5mg | $152 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0814 | ESI-09 ≥98% (HPLC) | 263707-16-0 | 25mg | $604 | 2024-03-01 | Buy |
| Cayman Chemical | 19130 | ESI-09 ≥95% | 263707-16-0 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19130 | ESI-09 ≥95% | 263707-16-0 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 19130 | ESI-09 ≥95% | 263707-16-0 | 10mg | $153 | 2024-03-01 | Buy |
ESI 09 Chemical Properties,Uses,Production
Uses
ESI 09 acts as an EPAC inhibitor, preventing EPAC-mediated insulin release form β-pancreatic cells. Selective control for EPAC over PKA and decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells.
Biochem/physiol Actions
ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP). ESI-09 inhibits EPAC1 and EPAC2 with IC50 values of 3.2 and 1.4 μM, respectively, with no activity against PKA at 25 μM. In pancreatic cell lines, the compound blocks phosphorylation of Akt and insulin secretion. ESI-09 inhibits migration of pancreatic cancer cell lines.
storage
Store at +4°C
ESI 09 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 80)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 | info@longyupharma.com | China | 2531 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Hebei Bonster Technology Co.,Limited | +8613315996897 | bsterltd.wendy@gmail.com | China | 796 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
263707-16-0(ESI 09)Related Search:
ESI 09
ESI09
ESI-09
(E)-3-(5-tert-butylisoxazol-3-yl)-2-(2-(3-chlorophenyl)hydrazono)-3-oxopropanenitrile
α-[2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-b-oxo-3-isoxazolepropanenitrile
alpha-[(3-Chlorophenyl)hydrazono]-5-(1,1-dimethylethyl)-beta-oxo-3-isoxazolepropanenitrile
α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile
3-Isoxazolepropanenitrile, α-[2-(3-chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-
(E)-2-(5-(tert-butyl)isoxazol-3-yl)-N-(3-chlorophenyl)-2-oxoacetohydrazonoyl cyanide
3-?Isoxazolepropanenitr?ile, α-?[2-?(3-?chlorophenyl)?hydrazinylidene]?-?5-?(1,?1-?dimethylethyl)?-?β-?oxo-
2-(5-(tert-Butyl)isoxazol-3-yl)-N-(3-chlorophenyl)-2-oxoacetohydrazonoyl cyanide
Virus Protease,inhibit,ESI 09,ESI09,Inhibitor,ESI-09
263707-16-0
Inhibitors