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AZ-5104

AZ-5104 Structure
AZ-5104 structure
CAS No.
1421373-98-9
Chemical Name:
AZ-5104
Synonyms
AZ7550;AZ5104;AZ-5104;CS-1709;AZD5104;AZ-5104;AZ 5104;AZ5104; AZ-5104;Demethylated AZ9291;metabolite of AZD9291;Osimertinib Impurity A
CBNumber:
CB12741564
Molecular Formula:
C27H31N7O2
Molecular Weight:
485.58
MDL Number:
MFCD28899992
MOL File:
1421373-98-9.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:22
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AZ-5104 Properties

Melting point 158 - 160°C
Density 1.267±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly)
pka 12.68±0.70(Predicted)
form Solid
color Off-White
FDA UNII 2DWZ6SE1E1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362
NFPA 704
0
2 0

AZ-5104 price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17994 AZ 5104 ≥98% 1421373-98-9 5mg $62 2024-03-01 Buy
Cayman Chemical 17994 AZ 5104 ≥98% 1421373-98-9 10mg $115 2024-03-01 Buy
Cayman Chemical 17994 AZ 5104 ≥98% 1421373-98-9 25mg $270 2024-03-01 Buy
Cayman Chemical 17994 AZ 5104 ≥98% 1421373-98-9 50mg $477 2024-03-01 Buy
TRC A795170 AZ5104 1421373-98-9 1mg $55 2021-12-16 Buy
Product number Packaging Price Buy
17994 5mg $62 Buy
17994 10mg $115 Buy
17994 25mg $270 Buy
17994 50mg $477 Buy
A795170 1mg $55 Buy

AZ-5104 Chemical Properties,Uses,Production

Uses

AZ7550 is an impurity of the drug Osimertinib (A808075). Osimertinib is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).

Biological Activity

az5104, is the demethylated metabolite of azd-9291,is a potent egfr inhibitor. ic50 <1 nm, 6 nm, 1 nm, 25 nm, for egfr (l858r/t790m), egfr (l858r), egfr (l861q), and egfr (wildtype), respectively.egfr (epidermal growth factor receptor) is a receptor tyrosine kinase on the cell surface. the receptor activation leads to dimerization and tyrosine autophosphorylation. it induces downstream cellular responses such as modification in gene expression, cell proliferation and cytoskeletal rearrangement etc.compare to azd9291, az5104 has somewhat more potency in mutant egfr cell lines ex19del (2 nmol/l in pc-9), t790m (2 nmol/l in h1975), and wild-type egfr (33 nmol/l in lovo) cell lines. in a phenotypic assay, az5104 showed a greater potency across cell lines in a phenotypic assay.3 hours after oral dosing in the mouse, the circulating active metabolites in plasma is 33% for az5104. in both c/l858r and c/l+t mice, 5 mg/kg/day dose of az5104, also show efficacy in shrinking tumors.

References

1. cross da, ashton se, ghiorghiu s et al. azd9291, an irreversible egfr tki, overcomes t790m-mediated resistance to egfr inhibitors in lung cancer. cancer discov. 2014 sep;4(9):1046-61.

AZ-5104 Preparation Products And Raw materials

Raw materials

Preparation Products

AZ-5104 Suppliers

Global( 128)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 		+86-86-22-87899925 +86-8618522618860 18522618860@163.com China 694 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
CD Chemical Group Limited 		+8615986615575 info@codchem.com China 20356 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
CD Chemical Group Limited 		58

View Lastest Price from AZ-5104 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AZ-5104 pictures 2019-07-06 AZ-5104
1421373-98-9
 US $1.00 / KG 1KG 98-100% 1000kg Career Henan Chemical Co
  • AZ-5104 pictures
  • AZ-5104
    1421373-98-9
  • US $1.00 / KG
  • 98-100%
  • Career Henan Chemical Co

AZ-5104 Spectrum

AZ-5104(1421373-98-9)1HNMR

1421373-98-9(AZ-5104)Related Search:

1,2,4-Benzenetriamine, N4-[4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-pyrimidinyl]-N1-[2-(dimethylamino)ethyl]-5-methoxy-N1-methyl- Osimertinib Impurity 7 Osimertinib Impurity N 2-Propenamide, N-[2-[[2-(dimethyloxidoamino)ethyl]methyloxidoamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]- 1,2,4-Benzenetriamine, 5-methoxy-N1,N1-dimethyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-
1,2,4-Benzenetriamine, N4-[4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-pyrimidinyl]-5-methoxy-N1-methyl-N1-[2-(methylmethyl-d3-amino)ethyl]- Osimertinib Impurity M N-(2-(dimethylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide AZ 7550 1,4-Benzenediamine, 5-methoxy-N1,N1-dimethyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-2-nitro-
3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

1of3

AZ7550 N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide AZ-5104 AZ5104 N-[2-[[2-(Dimethylamino)ethyl]methylamino]-5-[[4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-4-methoxyphenyl]-2-propenamide 2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-5-[[4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-4-methoxyphenyl]- Osimertinib Impurity A N-(4-methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide CS-1709 AZ-5104;AZ 5104 AZD5104 N-[2-(2-dimethylaminoethylmethylamino)-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide AZ5104; AZ-5104 Demethylated AZ9291 metabolite of AZD9291 1421373-98-9 C27H31N7O2 Inhibitors