"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one
- CAS No.
- 14892-97-8
- Chemical Name:
- "6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one
- Synonyms
- -2-suL;6,7-diphenyL;SCR7 pyrazine;SCR7; SCR-7; SCR 7.;6,7-Diphenyl-2-thiolumazine;6,7-Diphenyl-2-sulfanylpteridin-4-ol;"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one;2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone;6,7-Diphenyl-2-thioxo-2,3-dihydropteridin-4(1H)-one;6,7-Diphenyl-2-thioxo-2,3-dihydropteridin-4(8H)-one
- CBNumber:
- CB12741690
- Molecular Formula:
- C18H12N4OS
- Molecular Weight:
- 332.38
- MDL Number:
- MFCD02167478
- MOL File:
- 14892-97-8.mol
- MSDS File:
- SDS
| Melting point | 209 °C |
|---|---|
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.14±0.60(Predicted) |
| form | powder |
| color | faintly yellow to dark yellow |
| CAS DataBase Reference | 14892-97-8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| HS Code | 2933.59.8000 |
"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1546 | SCR7 pyrazine ≥98% (HPLC) | 14892-97-8 | 5MG | $108 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1546 | SCR7 pyrazine ≥98% (HPLC) | 14892-97-8 | 25MG | $435 | 2024-03-01 | Buy |
| TCI Chemical | C3577 | SCR7 Pyrazine | 14892-97-8 | 10MG | $139 | 2024-03-01 | Buy |
| TCI Chemical | C3577 | SCR7 Pyrazine | 14892-97-8 | 50MG | $386 | 2024-03-01 | Buy |
| Cayman Chemical | 18015 | SCR7 pyrazine ≥95% | 14892-97-8 | 1mg | $25 | 2021-12-16 | Buy |
"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one Chemical Properties,Uses,Production
Uses
SCR7 pyrazine has been used as a non-homologous end joining (NHEJ) modulator to study its effect on CRISPR/Cas9-mediated editing.
General Description
SCR7 pyrazine is an inhibitor of DNA ligase IV.
Biological Activity
scr7 pyrazine is an inhibitor of dna ligase iv [1].dna ligase iv is involved in sealing of double-strand breaks (dsbs) during nonhomologous end-joining (nhej). dsbs have been considered as one of the most lethal types of dna damage within cells. unrepaired dsbs may lead to chromosomal rearrangements such as translocations and deletions, resulting in oncogenic transformations or cell death. in higher eukaryotes, nhej is one of the primary mechanisms of dsb repair and is active throughout the cell cycle. nhej plays a major role in providing resistance to cancer cells to these radio- and chemotherapy agents [1].scr7 blocked ligase iv-mediated joining by interfering with its dna binding in cell-free repair system. scr7 inhibited nhej in a ligase iv-dependent manner within cells, and activated the intrinsic apoptotic pathway. scr7 dose-dependent decreased cell proliferation in mcf7, a549, and hela cells with an ic50 of 40, 34, and 44 μm, respectively. in t47d, a2780, and ht1080 cells, the ic50 values were 8.5, 120, and 10 μm, respectively [1].scr7 treatment (10 mg/kg, six doses) significantly reduced breast adenocarcinoma-induced tumor and impeded tumor progression in mouse models in mouse models. coadministered of scr7 with dsb-inducing therapeutic modalities significantly enhanced their sensitivity.
Biochem/physiol Actions
SCR7 pyrazine is reported to be an inhibitor of non-homologous end joining (NHEJ) and has been shown to enhance the efficiency of CRISPR-Cas9 genome editing. The effect of SCR7 pyrazine on the efficiency and targeting precision of CRISPR applications has been shown to be cell type specific and context dependent. SCR7 pyrazine is a product of spontaneous cyclization of SCR7, first reported by Srivastava, M., et al.
storage
Store at +4°C
References
[1] srivastava m, nambiar m, sharma s, et al. an inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression[j]. cell, 2012, 151(7): 1474-1487.
"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 |
View Lastest Price from "6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-26 | "6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one
14892-97-8
|
US $1.00 / g | 1g | 99% | 200kg | Career Henan Chemical Co |
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- "6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one
14892-97-8
- US $1.00 / g
- 99%
- Career Henan Chemical Co