Trifluoperazine dihydrochloride
- CAS No.
- 440-17-5
- Chemical Name:
- Trifluoperazine dihydrochloride
- Synonyms
- Urinox;skf5019;Stelazin;eskazine;STELAZINE;Eskazinyl;Ai3-50137;Calmazine;tryptazine;Einecs 207-123-0
- CBNumber:
- CB1274387
- Molecular Formula:
- C21H26Cl2F3N3S
- Molecular Weight:
- 480.42
- MDL Number:
- MFCD00012656
- MOL File:
- 440-17-5.mol
- MSDS File:
- SDS
| Melting point | 243 °C (dec.)(lit.) |
|---|---|
| Flash point | 9℃ |
| storage temp. | -20°C |
| solubility | ethanol: soluble5mg/mL |
| pka | pK1 3.9, pK2 8.1(at 25℃) |
| form | powder |
| color | white to off-white |
| λmax | 312nm(MeOH)(lit.) |
| Merck | 14,9680 |
| BRN | 3820024 |
| Stability | Hygroscopic |
| CAS DataBase Reference | 440-17-5(CAS DataBase Reference) |
| FDA UNII | 6P1Y2SNF5V |
| NCI Drug Dictionary | Stelazine |
| EPA Substance Registry System | 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride (440-17-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H319-H336-H341-H372-H410 | |||||||||
| Precautionary statements | P201-P273-P301+P312+P330-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SP1750000 | |||||||||
| F | 3-10 | |||||||||
| HS Code | 29343000 | |||||||||
| NFPA 704 |
|
Trifluoperazine dihydrochloride price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T-117 | Trifluoperazine dihydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 440-17-5 | 1mL | $172 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1685000 | Trifluoperazine hydrochloride United States Pharmacopeia (USP) Reference Standard | 440-17-5 | 200mg | $261.6 | 2024-03-01 | Buy |
| TCI Chemical | T2849 | Trifluoperazine Dihydrochloride >98.0%(HPLC)(T) | 440-17-5 | 5g | $100 | 2024-03-01 | Buy |
| TCI Chemical | T2849 | Trifluoperazine Dihydrochloride >98.0%(HPLC)(T) | 440-17-5 | 25g | $347 | 2024-03-01 | Buy |
| Cayman Chemical | 15068 | Trifluoperazine (hydrochloride) ≥98% | 440-17-5 | 1g | $32 | 2024-03-01 | Buy |
Trifluoperazine dihydrochloride Chemical Properties,Uses,Production
Description
Trifluoperazine (TFP) is a phenothiazine compound with anti-
Chemical Properties
Cream Fine Powder
Originator
Stelazine,SKF,US,1958
Uses
Antipsychotic
Uses
Trifluoperazine dihydrochloride has been used as a calmodulin kinase antagonist in cultured Aplysia californica neurons. Trifluoperazine dihydrochloride has also been used as a PMCA inhibitor in mouse duodenal tissues to block the transcellular active calcium flux.
Manufacturing Process
A mixture of 17.2 grams of 2-trifluoromethylphenothiazine, 3.1 grams of sodamide and 14 grams of 1-(3'-chloropropyl)-4-methylpiperazine in 200 ml of xylene is heated at reflux for 2 hours. The salts are extracted into 150 ml of water. The xylene layer is then extracted with several portions of dilute hydrochloric acid. The acid extracts are combined and neutralized with ammonium hydroxide solution. The product, 10-[3'-(4''-methyl-1''- piperazinyl)-propyl]-2-trifluoromethylphenothiazine, is taken into benzene and purified by vacuum distillation, BP 202° to 210°C at 0.6 mm.
Therapeutic Function
Tranquilizer
General Description
Trifluoperazinehydrochloride, 10-[3-(4-Methyl-1-piperazinyl)propyl-[2-(trifluoromethyl)phenothiazine dihydrochloride (Stelazine).The absorption of trifluoperazine is erratic and variable andit is widely distributed into tissues. The excretion of trifluoperazineoccurs 50% via kidneys and the other 50% isthrough enterohepatic circulation. The metabolism and druginteractions of trifluoperazine are the same as with the otherphenothiazines. Trifluoperazine does not show any specificdrug interactions. Trifluoperazine is indicated for the managementof schizophrenia and short-term treatment ofnonpsychotic anxiety.
Biochem/physiol Actions
Trifluoperazine dihydrochloride is useful in treating schizophrenia, disturbed behavior, severe anxiety, nausea and vomiting.
Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of F-, NOx, SOx, and HCl. See also FLUORIDES.
Purification Methods
Recrystallise the salt from absolute EtOH, filter the crystals, dry them in vacuo and store them in tightly stoppered bottles because it is hygroscopic. It is soluble in H2O but insoluble in *C6H6, Et2O and alkaline aqueous solution. It has UV at 258 and 307.5nm (log 4.50 and 3.50) in EtOH (neutral species). [Craig max et al. J Org Chem 22 709 1957.] It is a calmodulin inhibitor [Levene & Weiss J Parmacol Exptl Ther 208 454 1978] and is a psychotropic agent [Fowler Arzneim.-Forsch 27 866 1977]. [Beilstein 27 III/IV 1353.]
Trifluoperazine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Trifluoperazine dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | +8615377521700 | wangwendy93@gmail.com | China | 868 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9427 | 58 |
View Lastest Price from Trifluoperazine dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-16 | Trifluoperazine dihydrochloride
440-17-5
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | |
 |
2021-07-24 | Trifluoperazine dihydrochloride USP/EP/BP
440-17-5
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2021-07-13 | Trifluoperazine dihydrochloride
440-17-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Trifluoperazine dihydrochloride
440-17-5
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
-
- Trifluoperazine dihydrochloride USP/EP/BP
440-17-5
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Trifluoperazine dihydrochloride
440-17-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd