LL Z1640-2
- CAS No.
- 253863-19-3
- Chemical Name:
- LL Z1640-2
- Synonyms
- nol;C 292;L 783279;FR148083;f 152 A1;5Z-7-Oxoze&ÆTAK1 inhibitor 5ZO);5Z-7-Oxozeaenol >=98% (HPLC);1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-;(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
- CBNumber:
- CB12744545
- Molecular Formula:
- C19H22O7
- Molecular Weight:
- 362.37
- MDL Number:
- MFCD12912700
- MOL File:
- 253863-19-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 3507909090 | |||||||||
| NFPA 704 |
|
LL Z1640-2 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | O9890 | 5Z-7-Oxozeaenol ≥98% (HPLC) | 253863-19-3 | 1mg | $221 | 2024-03-01 | Buy |
| Cayman Chemical | 17459 | (5Z)-7-Oxo Zeaenol ≥99% | 253863-19-3 | 1mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 17459 | (5Z)-7-Oxo Zeaenol ≥99% | 253863-19-3 | 5mg | $299 | 2024-03-01 | Buy |
| TRC | O870678 | (5Z)-7-Oxozeaenol | 253863-19-3 | 5mg | $655 | 2021-12-16 | Buy |
| Apolloscientific | BIL0128 | LL-Z-1640-2 | 253863-19-3 | 10mg | $595 | 2021-12-16 | Buy |
LL Z1640-2 Chemical Properties,Uses,Production
Uses
(5Z)-7-Oxozeaenol is a highly potent inhibitor of TAK1, which is a member of the mitogen-acitvated kinase kinase kinase (MAPKKK) family. 5Z-?7-?Oxozeaenol blocked interleukin-?1-?induced activation of TAK1, JNK?/p38 MAPK, IκB kinases, and NF-?κB, resulting in inhibition of cyclooxgenase-?2 production.
Uses
LL Z1640-2 (5Z-7-oxozeaenol) is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.
Definition
ChEBI: 5Z-7-oxozeaenol is a macrolide that is the 7-oxo derivative of zeaenol (the 5Z stereoisomer). Isolated from Fungi, it exhibits cytotoxic, antibacterial and inhibitory activity against NF-kappaB. It has a role as a metabolite, an antibacterial agent, an antineoplastic agent and a NF-kappaB inhibitor. It is an aromatic ether, a macrolide, a member of phenols, a secondary alcohol and a secondary alpha-hydroxy ketone.
Biochem/physiol Actions
The anti-inflammatory effects of 5Z-7-oxozeaenol may affect cardiac hypertrophy.
storage
Desiccate at -20°C
LL Z1640-2 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3419 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7893 | 56 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Aikon International Limited | 025-58859352 18068836627 | sales01@aikonchem.com | China | 15085 | 58 |
| Beijing OKA biological technology co., LTD | 010-62971590 18548936886 | 3462612863@qq.com | China | 6912 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55672 | 58 |