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Liproxstatin-1

Liproxstatin-1 Structure
Liproxstatin-1 structure
CAS No.
950455-15-9
Chemical Name:
Liproxstatin-1
Synonyms
CS-1656;Liproxstatin-1;Liproxstatin-1 USP/EP/BP;LIPROXSTATIN-1;LIPROXSTATIN1;Liproxstatin-1 HCl(free base);N-(3-Chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine;N-(3-Chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine;N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4'-piperidine]-2-amine;N-[(3-chlorophenyl)methyl]-1'H-spiro[piperidine-4,2'-quinoxaline]-3'-amine;N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine
CBNumber:
CB12744611
Molecular Formula:
C19H21ClN4
Molecular Weight:
340.85
MDL Number:
MFCD14948691
MOL File:
950455-15-9.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:06
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Liproxstatin-1 Properties

Boiling point 581.4±50.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (15 mg/ml)
form powder
pka 9.45±0.40(Predicted)
color white to light brown
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Liproxstatin-1 price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1414 Liproxstatin-1 >98% (HPLC) 950455-15-9 5MG $109 2023-06-20 Buy
Sigma-Aldrich SML1414 Liproxstatin-1 >98% (HPLC) 950455-15-9 25MG $428 2023-06-20 Buy
Cayman Chemical 17730 Liproxstatin-1 ≥95% 950455-15-9 5mg $59 2024-03-01 Buy
Cayman Chemical 17730 Liproxstatin-1 ≥95% 950455-15-9 10mg $112 2024-03-01 Buy
Cayman Chemical 17730 Liproxstatin-1 ≥95% 950455-15-9 25mg $236 2024-03-01 Buy
Product number Packaging Price Buy
SML1414 5MG $109 Buy
SML1414 25MG $428 Buy
17730 5mg $59 Buy
17730 10mg $112 Buy
17730 25mg $236 Buy

Liproxstatin-1 Chemical Properties,Uses,Production

Description

Liproxstatin-1 is a ferroptosis inhibitor. It inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in mouse embryonic fibroblasts (MEFs) with an inducible knockdown of glutathione peroxidase 4 (Gpx4-/- MEFs) when used at a concentration of 50 nM. Liproxstatin-1 also inhibits ferroptosis induced by the ferroptosis-inducing agents L-buthionine sulphoximine (BSO), erastin , and (1S,3R)-RSL3 in a concentration-dependent manner in MEFs, but does not inhibit necroptosis, apoptosis, or necrosis. It inhibits cell death and lipid peroxidation induced by (1S,3R)-RSL3 in human renal proximal tubule epithelial cells. Liproxstatin-1 (10 mg/kg) increases survival and decreases TUNEL+ kidney cells in inducible Gpx4-/- mice and reduces tissue injury in a mouse model of hepatic ischemia/reperfusion injury. It is also an antioxidant that inhibits autooxidation of lipids by trapping peroxyl radicals.

Uses

Liproxstatin-1 has been used as a cell death inhibitor in the cell viability assay and for the determination of lipid peroxidation.

Definition

ChEBI: Liproxstatin-1 is an azaspiro compound that is 1'H-spiro[piperidine-4,2'-quinoxaline] in which the hydrogen at position 3' is replaced by a (3-chlorobenzyl)amino group. It is a potent inhibitor of ferroptosis. It has a role as a ferroptosis inhibitor, a radical scavenger, an antioxidant and a cardioprotective agent. It is a member of monochlorobenzenes, a secondary amino compound, an azaspiro compound and an organic heterotricyclic compound.

Biochem/physiol Actions

Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS). Liproxstatin-1 suppressed ferroptosis in human cells and in an ischaemia/reperfusion-induced tissue injury model in mice. Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice.

References

Angeli et al. (2014), Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice; Nat. Chem. Biol. 16 1180 Feng et al. (2019), Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels; Biochem. Biophys. Res. Commun. 520 606 Zilka et al. (2017), On the mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death; ACS Cent. Sci. 3 232

Liproxstatin-1 Preparation Products And Raw materials

Raw materials

Preparation Products

Liproxstatin-1 Suppliers

Global( 102)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569265 +86-18612256290 1056@dideu.com China 3632 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29271 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Biochempartner 		58
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58
career henan chemical co 		58
Shaanxi Dideu Medichem Co. Ltd 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58

View Lastest Price from Liproxstatin-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Liproxstatin-1 pictures 2021-07-20 Liproxstatin-1
950455-15-9
 US $0.00-0.00 / KG 5mg 99% 2000tons Shaanxi Dideu Medichem Co. Ltd
N-(3-Chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine pictures 2020-01-02 N-(3-Chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine
950455-15-9
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • Liproxstatin-1 pictures
  • Liproxstatin-1
    950455-15-9
  • US $0.00-0.00 / KG
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd

Liproxstatin-1 Spectrum

Liproxstatin-1(950455-15-9)1HNMR

950455-15-9(Liproxstatin-1)Related Search:

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide Tigecycline Elafibranor(GFT505) Acalabrutinib Y27632 (hydrochloride)
Necrostatin-1 Z-VAD-FMK

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Liproxstatin-1 N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine N-(3-Chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine LIPROXSTATIN-1;LIPROXSTATIN1 CS-1656 N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4'-piperidine]-2-amine Liproxstatin-1 USP/EP/BP N-[(3-chlorophenyl)methyl]-1'H-spiro[piperidine-4,2'-quinoxaline]-3'-amine Spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine, N-[(3-chlorophenyl)methyl]- Liproxstatin-1 HCl(free base) N-(3-Chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine 950455-15-9 Inhibitors