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ChemicalBook >> CAS DataBase List >>2-Chloro-5-methoxy-4-methylpyrimidine

2-Chloro-5-methoxy-4-methylpyrimidine

2-Chloro-5-methoxy-4-methylpyrimidine Structure
2-Chloro-5-methoxy-4-methylpyrimidine structure
CAS No.
1245506-61-9
Chemical Name:
2-Chloro-5-methoxy-4-methylpyrimidine
Synonyms
2-Chloro-5-methoxy-4-methylpyrimidine;Pyrimidine, 2-chloro-5-methoxy-4-methyl-
CBNumber:
CB12750151
Molecular Formula:
C6H7ClN2O
Molecular Weight:
158.59
MDL Number:
MFCD22394135
MOL File:
1245506-61-9.mol
Last updated:2025-07-24 18:13:45
Product description Number Pack Size Price
2-Chloro-5-methoxy-4-methylpyrimidine CS-0036515 1g $295
2-chloro-5-methoxy-4-methylpyrimidine 5134AQ 1g $410
2-Chloro-5-methoxy-4-methylpyrimidine CS-0036515 5g $885
2-chloro-5-methoxy-4-methylpyrimidine 5134AQ 5g $1133.6
2-chloro-5-methoxy-4-methylpyrimidine 5134AQ 10g $1901.6
Request For Quotation

2-Chloro-5-methoxy-4-methylpyrimidine Properties

Boiling point 255.6±20.0 °C(Predicted)
Density 1.237±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -0.76±0.29(Predicted)
Appearance Light brown to brown Solid

2-Chloro-5-methoxy-4-methylpyrimidine price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0036515 2-Chloro-5-methoxy-4-methylpyrimidine 1245506-61-9 1g $295 2021-12-16 Buy
AK Scientific 5134AQ 2-chloro-5-methoxy-4-methylpyrimidine 1245506-61-9 1g $410 2021-12-16 Buy
ChemScene CS-0036515 2-Chloro-5-methoxy-4-methylpyrimidine 1245506-61-9 5g $885 2021-12-16 Buy
AK Scientific 5134AQ 2-chloro-5-methoxy-4-methylpyrimidine 1245506-61-9 5g $1133.6 2021-12-16 Buy
AK Scientific 5134AQ 2-chloro-5-methoxy-4-methylpyrimidine 1245506-61-9 10g $1901.6 2021-12-16 Buy
Product number Packaging Price Buy
CS-0036515 1g $295 Buy
5134AQ 1g $410 Buy
CS-0036515 5g $885 Buy
5134AQ 5g $1133.6 Buy
5134AQ 10g $1901.6 Buy

2-Chloro-5-methoxy-4-methylpyrimidine Chemical Properties,Uses,Production

Synthesis

Methylmagnesium Bromide

75-16-1

2,4-Dichloro-5-methoxypyrimidine

19646-07-2

2-Chloro-5-methoxy-4-methylpyrimidine

1245506-61-9

To a mixed solution of 2,4-dichloro-5-methoxypyrimidine (1 g, 5.59 mmol) in tetrahydrofuran (32.2 mL) with N-methyl-2-pyrrolidinone (2.424 mL) was added ferric acetylacetonate (0.197 g, 0.559 mmol) and the mixture was cooled to 0°C under nitrogen protection. Subsequently, methylmagnesium bromide solution (2.62 mL, 8.38 mmol, 3.2 M, dissolved in 2-methyltetrahydrofuran) was added slowly and dropwise. The reaction mixture was stirred at 0 °C for 30 min under nitrogen atmosphere. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution (10 mL) and the mixture was gradually warmed to room temperature. Ether was added for partitioning and the aqueous phase was further extracted with ether (4 x 15 mL). All organic phases were combined, dried over hydrophobic glass material and concentrated under reduced pressure to give an orange oily crude product. The crude product was dissolved in dichloromethane (3 mL) and purified by chromatography on a silica gel column (25 g) using a gradient elution of 0-30% cyclohexane/ethyl acetate, and 10 column volumes of eluate were collected. Fractions containing the target product were combined and the solvent was evaporated under reduced pressure to afford the white solid product 2-chloro-5-methoxy-4-methylpyrimidine (475 mg, 3.00 mmol, 54% yield).LCMS (2 mm formic acid): retention time Rt = 0.64 min, [M+H]+ = 159.

References

[1] Patent: WO2014/140076, 2014, A1. Location in patent: Page/Page column 164; 165

2-Chloro-5-methoxy-4-methylpyrimidine Preparation Products And Raw materials

Raw materials

Methylmagnesium Bromide 2,4-Dichloro-5-methoxypyrimidine 2-Methyltetrahydrofuran N-Methyl-2-pyrrolidone Ferric acetylacetonate

Preparation Products

2-Chloro-5-methoxy-4-methylpyrimidine Suppliers

Global( 44)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
Cochemical Co. Ltd. 		+86-029-86115547 +86-17791676824 sales@cochemical.com China 3952 58
Hangzhou Milon Pharmatech Co.,Ltd. 		+8618083715844 sales02@milonpharm.com China 292 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42934 64
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7247 62
Shanghai Synthfine Chemical Co.,Ltd 15921303235 sales@synthfine.com China 1035 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
Labnetwork lnc. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
Cochemical Co. Ltd. 		58
Hangzhou Milon Pharmatech Co.,Ltd. 		58
Amadis Chemical Company Limited 		58
Shanghai Hanhong Scientific Co.,Ltd. 64
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
Shanghai Synthfine Chemical Co.,Ltd 58

2-Chloro-5-methoxy-4-methylpyrimidine Spectrum

2-Chloro-5-methoxy-4-methylpyrimidine(1245506-61-9)1HNMR
2-Chloro-5-methoxy-4-methylpyrimidine Pyrimidine, 2-chloro-5-methoxy-4-methyl- 1245506-61-9