4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
![4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Structure](CAS/20180629/GIF/854847-61-3.gif)
- CAS No.
- 854847-61-3
- Chemical Name:
- 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
- Synonyms
- HLY78;5-j]phenanthridine;4-Ethyl-5-methyl-5;HLY78 >=98% (HPLC);HLY78, 10 mM in DMSO;4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine;4-Ethyl-5,6-Dihydro-5-methyl-[1,3]dioxolo[4,5-j]phenanthridine;[1,3]Dioxolo[4,5-j]phenanthridine, 4-ethyl-5,6-dihydro-5-methyl-;Beta catenin,Neuronal apoptosis,HLY78,gastric cancer,SAH,subarachnoid hemorrhage,tumor cells,β-catenin,LRP6,inhibit,Inhibitor,anti-apoptotic,Blood-brain barrier,embryonic cells,Apoptosis,HLY-78,Wnt,HLY 78
- CBNumber:
- CB12750601
- Molecular Formula:
- C17H17NO2
- Molecular Weight:
- 267.32
- MDL Number:
- MFCD26961120
- MOL File:
- 854847-61-3.mol
| Boiling point | 444.0±34.0 °C(Predicted) |
|---|---|
| Density | 1.208±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| form | powder |
| pka | 4?+-.0.20(Predicted) |
| color | white to beige |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0833 | HLY78 ≥98% (HPLC) | 854847-61-3 | 5mg | $94.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0833 | HLY78 ≥98% (HPLC) | 854847-61-3 | 25mg | $479 | 2024-03-01 | Buy |
| Cayman Chemical | 19087 | HLY78 ≥98% | 854847-61-3 | 1mg | $45 | 2024-03-01 | Buy |
| Cayman Chemical | 19087 | HLY78 ≥98% | 854847-61-3 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 19087 | HLY78 ≥98% | 854847-61-3 | 10mg | $177 | 2024-03-01 | Buy |
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Chemical Properties,Uses,Production
Uses
HLY78, a Lycorine.html" class="link-product" target="_blank">Lycorine (HY-N0288) derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research[1][2][3].
Biological Activity
hly78 is a positive modulator of the wnt/β-catenin pathway.the evolutionarily conserved wnt/β-catenin signaling pathway has important roles in embryonic development and human diseases. during embryogenesis, the wnt signaling pathway regulates cell fate specification, differentiation, proliferation and survival. inappropriate regulation of the wnt signaling pathway is usually related to the progression of various human diseases including cancer, familial exudative vitreoretinopathy, alzheimer’s disease, and bone formation disorders.
in vitro
by screening a synthetic chemical library of lycorine derivatives, hly78 was identified as an activator of the wnt/β-catenin signaling pathway, which acted in a wnt ligand-dependent manner. hly78 was found to be alble to target the dix domain of axin and potentiate the axin-lrp6 association, therefore leading to the promotion of lrp6 phosphorylation and wnt signaling transduction. in addition, this study also identified the critical residues on axin for hly78 binding and suggested that hly78 might weaken the autoinhibition of axin1 [1].
in vivo
in-vivo study showed that hly78 could synergistically act with wnt in the embryonic development of zebrafish and increase the expression of the conserved hematopoietic stem cell (hsc) markers, cmyb and runx1, in zebrafish embryos [1].
References
[1] wang, s. ,yin, j.,chen, d., et al. small-molecule modulation of wnt signaling via modulating the axin-lrp5/6 interaction. nature chemical biology 9, 579-585 (2013).
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32265 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38659 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4613 | 55 | |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
