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ANTIPAIN, DIHYDROCHLORIDE

ANTIPAIN, DIHYDROCHLORIDE structure

CAS No.: 37682-72-7

Chemical Name:: ANTIPAIN, DIHYDROCHLORIDE

Synonyms: ANTIPAIN;BDBM32804;BDBM 32804;BDBM-32804;Antipain HCl;Antipain 2HCI;ANTIPAIN (2HCL);BDBM 32804, Antipain;ANTIPAIN HYDROCHLORIDE;Phe-Arg-Val-Arg-CHO.2HCl

CBNumber:: CB1279463

Molecular Formula:: C27H46Cl2N10O6

Molecular Weight:: 677.62

MDL Number:: MFCD00135957

MOL File:: 37682-72-7.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:19

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ANTIPAIN, DIHYDROCHLORIDE Properties

Melting point	209-217 °C
Boiling point	652.92°C (rough estimate)
Density	1.2423 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	-20°C
solubility	H₂O: 50 mg/mL
form	White powder
color	White
Water Solubility	0.01M in water
Stability	Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
FDA UNII	GWZ8LOU6OG

SAFETY

Risk and Safety Statements

Precautionary statements	P261-P271-P280
Safety Statements	22-24/25
WGK Germany	3
RTECS	YV9350800
F	1-10
HS Code	2934999090

ANTIPAIN, DIHYDROCHLORIDE price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	178220	Antipain, Hydrochloride	37682-72-7	5mg	$85.2	2024-03-01	Buy
Sigma-Aldrich	178220	Antipain, Hydrochloride	37682-72-7	10mg	$144	2024-03-01	Buy
Sigma-Aldrich	11004646001	Antipain dihydrochloride	37682-72-7	10mg	$244	2024-03-01	Buy
Alfa Aesar	J63680	Antipain dihydrochloride	37682-72-7	5mg	$73.65	2024-03-01	Buy
Cayman Chemical	26705	Antipain (hydrochloride)	37682-72-7	5mg	$43	2024-03-01	Buy

Product number	Packaging	Price	Buy
178220	5mg	$85.2	Buy
178220	10mg	$144	Buy
11004646001	10mg	$244	Buy
J63680	5mg	$73.65	Buy
26705	5mg	$43	Buy

ANTIPAIN, DIHYDROCHLORIDE Chemical Properties,Uses,Production

Description

Antipain is a protease inhibitor originally isolated from actinomycetes. It inhibits thrombokinase, plasmin, trypsin, and papain in vitro (IC₅₀s = 20, 93, 0.26, and 0.16 μg/ml, respectively). Antipain (6-600 μg/ml) inhibits the morphological transformation of and increases frequency of chromosomal aberrations in Syrian hamster embryo cells induced by N-methyl-N''-nitro-N-nitroso-guanidine (MNNG). In vivo, antipain (25-100 mg/kg) suppresses urethan-induced formation of cleft palates and cleft lips in mice.

Uses

Antipain inhibits trypsin, papain, and catherpsins A and B (a reversible inhibitor of cysteine and serine proteases). It is used to evaluate the role of proteases in cell transformations. It is used to help identify new proteases.

Uses

Concentrations for 50% inhibition (μg/ml): papain, 0.16trypsin, 0.26cathepsin A, 1.19cathepsin B, 0.59cathepsin D, 125plasmin, >93chymotrypsin and pepsin, >250It also has been reported to inhibit calpain I, (porcine) with Ki = 1.4 μM

General Description

Antipain is a protease inhibitor isolated from actinomycetes. It inhibits thrombokinase and blood coagulation.

Biochem/physiol Actions

Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.

References

1) Umezawa?et al.?(1976),?Structures and activities of protease inhibitors of microbial origin; Method Enzymol.,?45?678 2) Gotoh?et al.?(2001),?Proteolytic activity and recombinant protein production in virus-infected Sf-9 insect cell cultures supplemented with carboxyl and cysteine protease inhibitors; J. Biosci. Bioeng.,?92?248 3) Hockensmith?et al. (2016), Identification and characterization of a chymotrypsin-like serine protease from periodontal pathogen, Tannerella forsythia; Microb. Pathog.,?100?37 4) Mat Amin?et al. (2004),?Proteinases in Naegleria Fowleri (strain NF3), a pathogenic amoeba: a preliminary study.; Trop. Biomed.,?21?57 5) Moriyyasu & Inoue (2008),?Use of protease inhibitor for detecting autophagy in plants; Methods Enzymol.,?451?557

ANTIPAIN, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

ANTIPAIN, DIHYDROCHLORIDE Suppliers

Global( 99)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Syntechem Co.,Ltd		info@syntechem.com	China	12990	57
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12338	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Nextpeptide Inc	58
LEAPCHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
GL Biochem (Shanghai) Ltd	64
Syntechem Co.,Ltd	57
Beijing HuaMeiHuLiBiological Chemical	58

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ANTIPAIN HYDROCHLORIDE DIHYDRATE ANTIPAIN, DIHYDROCHLORIDE ANTIPAIN MONOHYDROCHLORIDE DIHYDRATE

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N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HYDROCHLORIDE l-valinamide,n(sup2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-l-arginyl-n-( ANTIPAIN HYDROCHLORIDE FROMMICROBIAL SOU RCE L-Valinamide, N2-(1-carboxy-2-phenylethyl)aminocarbonyl-L-arginyl-N-4-(aminoiminomethyl)amino-1-formylbutyl-, dihydrochloride antipain dihydrochloride from microbial source n-(nα-carbonyl-arg-val-arg-al)-phe N-(N-Carbonyl-Arg-Val-Arg-al)-Phe dihydrochloride TRIS-GLYCINE BUFFER 10X PWD PROTEOMICS N2-[[[(1S)-1-Carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide hydrochloride (1:2) L-Valinamide, N(sup 2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-, dihydrochloride Phe-Arg-Val-Arg-CHO.2HCl ANTIPAIN ;PHE-ARG-VAL-ARG-CHO.2HCL (9S,12S)-1-aMino-16-benzyl-6-forMyl-12-(3-guanidinopropyl)-1-iMino-9-isopropyl-8,11,14-trioxo-2,7,10,13,15-pentaazaheptadecan-17-oic acid dihydrochloride L-Valinamide,N2-[[[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-,hydrochloride (1:2) EZNA KIT ISOLATION FFPE RNA ANTIPAIN ANTIPAIN (2HCL) ANTIPAIN HYDROCHLORIDE [(S)-I-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-L-ARG-L-VAL-ARGINAL [(S)-1-CARBOXY-2-PHENETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE (S)-[1-CARBOXY-2-PHENYL-ETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARG-AL HYDROCHLORIDE [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARGINAL 2HCL [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-L-ARGININAL [(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYL-ARGININAL [(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYLARGININAL HYDROCHLORIDE N-(-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL)PHE N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HCL ANTIPAIN, DIHYDROCHLORIDE Antipain 2HCI Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem Antipain dihydrochloride from microbial source protease inhibitor Antipain HCl BDBM 32804 BDBM32804 BDBM-32804 BDBM 32804, Antipain 37682-72-7 C27H44N10O62HCl C27H44N10O62ClH C27H46Cl2N10O6 BioChemical Biochemicals and Reagents Antibiotics Analytical Enzymes Antibiotics A to Z Antibiotics A-F Enzymes, Inhibitors, and Substrates Trypsin Inhibitors peptides inhibitor AN-AZ Antineoplastic and Immunosuppressive Antibiotics Broad Spectrum Inhibitors of Proteolytic Enzyme Classes Cathepsin D Cysteine Protease Inhibitor A to C