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Erythromycin Estolate

Erythromycin Estolate
Erythromycin Estolate structure
Chemical Name:
Erythromycin Estolate
Eriscel;ilosone;Togiren;eromycin;Eupragin;eritroger;Erytrarco;Estomicina;NSC 263364;roxomicina
Molecular Formula:
Formula Weight:
MOL File:

Erythromycin Estolate Properties

Melting point:
135-140°C dec.
Boiling point:
1.0053 (rough estimate)
refractive index 
1.6550 (estimate)
Flash point:
storage temp. 
-20°C Freezer
chloroform: soluble4.0ML, clear, colorless (200 mg + 4.0 mL Chloroform)
6.9(at 25℃)
Water Solubility 
Freely soluble in organic solvents, practically insoluble in water /n
Light Sensitive
CAS DataBase Reference
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-42/43-36/37/38
Safety Statements  22-36-26
WGK Germany  3
RTECS  KF5775000
HS Code  29419000
Toxicity LD50 orally in rats: >5000 mg/kg (Goldenthal)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Erythromycin Estolate price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E1400000 Erythromycin estolate European Pharmacopoeia (EP) Reference Standard 3521-62-8 e1400000 $179 2018-11-23 Buy
Sigma-Aldrich 1243002 Erythromycin estolate 3521-62-8 200mg $357.7 2018-11-20 Buy
Alfa Aesar J66548 Erythromycin estolate 3521-62-8 5g $81.2 2018-11-13 Buy

Erythromycin Estolate Chemical Properties,Uses,Production

Chemical Properties

Long Needles


Macrolides Antibiotics


Used as an antibacterial agent. LD50 >5000 mg/kg for oral administration to rats

brand name

Antibio-aberel;Apo-erythro-s;Bio-exazol;Biometran;Biomicron;Chemthromycin;Cimetrin;Cusimicina balsamica;Doboiosol;Dowmicyn;Dreimicina;Duozplin vitaminado;Dynabiotal;Ees-200;Ees-400;E-mycine;Endoeritrina;Erimec;Erirobios;Eritrazol;Eritrobios;Eritrobiotic;Eritrocin;Eritrodes;Eritronicol;Eritropan;Eritroveinte;Eritrovienite;Eritrowolf;Eritro-wolf;Erymycin;Eryped;Ery-tar;Erythromictine;Erythro-prat;Ery-toxinal;Erytrodol;Erytro-prot;Eryt-toxinal;Espimina;Estimina;Estomiicina;Estomycin;Fesmicina;Ilosone pulvules;Ilosone ready-mix;Ilothycin;Kesso-mycin;Laucetin;Laurilin;Lauritran;Liferitrin;Loderm;Lubomycina;Lubomycine;Makrocyklina;Manilina;Marocid;Neo-ilolycina;Neo-iloticina;Niux;Novorythro;Propriocin enfante;Prospiocine;Proterytrin;Pulmomas;Purmycin;Ritromin;Roxo chemil;Roxochemil;Rp-mycin;Rubibacter;Selvicin;Spetrasone;Stella micina;Taimoxin;Togerin;Togrien;Tosinova;Tropoxin;Wyamycin s.

World Health Organization (WHO)

Erythromycin estolate, a macrolide antibiotic, was introduced in 1958 for the treatment of gram-positive infections. By the early 1970s its use had been associated with a higher incidence of hepatic toxicity than that seen with other salts and esters of erythromycin. This led to its withdrawal by some regulatory authorities whereas others required the addition of a warning in the product information. Evidence that the estolate ester is more hepatotoxic than other salts or esters has subsequently been disputed. It has been claimed to be the most effective ester for treatment of Legionnaire's disease and preparations remain widely available. (Reference: (BMJOAE) British Medical Journal, 286, 1954, 1983)

General Description

Erythromycin estolate, erythromycin propionate lauryl sulfate(Ilosone), is the lauryl sulfate salt of the 2'-propionateester of erythromycin. Erythromycin estolate is acid stableand absorbed as the propionate ester. The ester undergoesslow hydrolysis in vivo. Only the free base binds to bacterialribosomes. Some evidence, however, suggests that theester is taken up by bacterial cells more rapidly than thefree base and undergoes hydrolysis by bacterial esteraseswithin the cells. The incidence of cholestatic hepatitis is reportedlyhigher with the estolate than with other erythromycinpreparations.
Erythromycin estolate occurs as long needles that aresparingly soluble in water but soluble in organic solvents. administration for the treatment of serious infections,such as Legionnaires disease, or when oral administrationis not possible. Solutions are stable for 1 week whenrefrigerated.

Erythromycin Estolate Preparation Products And Raw materials

Raw materials

Preparation Products

Erythromycin Estolate Suppliers

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Erythromycin Estolate Spectrum

3521-62-8(Erythromycin Estolate)Related Search:

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