Erythromycin Estolate

Erythromycin Estolate Properties

Melting point	135-140°C dec.
Boiling point	743℃
Density	1.0053 (rough estimate)
refractive index	1.6550 (estimate)
Flash point	>110°(230°F)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	chloroform: soluble4.0ML, clear, colorless (200 mg + 4.0 mL Chloroform)
pka	6.9(at 25℃)
color	white
Water Solubility	Freely soluble in organic solvents, practically insoluble in water /n
Sensitive	Light Sensitive
CAS DataBase Reference	3521-62-8
FDA UNII	XRJ2P631HP

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H302-H317-H334
Precautionary statements	P261-P264-P280-P301+P312-P302+P352-P304+P340+P312
Hazard Codes	Xn,Xi
Risk Statements	22-42/43-36/37/38
Safety Statements	22-36-26
WGK Germany	3
RTECS	KF5775000
HS Code	29419000
Toxicity	LD50 orally in rats: >5000 mg/kg (Goldenthal)

Erythromycin Estolate price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	E1400000	Erythromycin estolate European Pharmacopoeia (EP) Reference Standard	3521-62-8	e1400000	$220	2024-03-01	Buy
Sigma-Aldrich	1243002	Erythromycin estolate	3521-62-8	200mg	$401	2024-03-01	Buy
Alfa Aesar	J66548	Erythromycin estolate	3521-62-8	5g	$160	2021-12-16	Buy
TRC	E650000	Erythromycin estolate	3521-62-8	10g	$195	2021-12-16	Buy
TRC	E650000	Erythromycin estolate	3521-62-8	500mg	$65	2021-12-16	Buy

Product number	Packaging	Price	Buy
E1400000	e1400000	$220	Buy
1243002	200mg	$401	Buy
J66548	5g	$160	Buy
E650000	10g	$195	Buy
E650000	500mg	$65	Buy

Erythromycin Estolate Chemical Properties,Uses,Production

Description

Erythromycin estolate was synthesized by the Lilly Research Laboratories in 1959. It shows a higher and longer lasting serum level than erythromycin and the other esters, ethylsuccinate and stearate, when administered orally. This antibiotic is stable against gastric acids, and after oral absorption it is hydrolyzed gradually into erythromycin. Long-term usage of erythromycin estolate is toxic to the liver. Erythromycin ethylsuccinate [41342-53-4], (C43H75NO16, Mr 862.07) and erythromycin stearate [643-22-1] (C37H67NO13 · C18H36O2, Mr 1018.43) also have been used orally, and erythromycin lactobionate [3847-29-8] (C37H67NO13 · C12H22NO12, Mr 1092.25) has been used by intravenous administration and opthalmic topical application

Chemical Properties

Long Needles

Originator

Ilosone,Dista,US,1958

Uses

Used as an antibacterial agent. LD50 >5000 mg/kg for oral administration to rats.

Uses

Macrolides Antibiotics

Definition

ChEBI: Erythromycin estolate is an aminoglycoside sulfate salt and an erythromycin derivative. It has a role as an enzyme inhibitor. It contains an erythromycin A 2'-propanoate.

Manufacturing Process

16.7 grams of monopropionylerythromycin are dissolved in 50 ml of warm acetone. To the solution are added 6.4 grams of sodium lauryl sulfate dissolved in 50 ml of distilled water containing 2 ml of glacial acetic acid. The white crystalline precipitate of rnonopropionylerythromycin lauryl sulfate which separates is filtered off and dried. It melts at about 135° to 137°C.

brand name

Antibio-aberel;Apo-erythro-s;Bio-exazol;Biometran;Biomicron;Chemthromycin;Cimetrin;Cusimicina balsamica;Doboiosol;Dowmicyn;Dreimicina;Duozplin vitaminado;Dynabiotal;Ees-200;Ees-400;E-mycine;Endoeritrina;Erimec;Erirobios;Eritrazol;Eritrobios;Eritrobiotic;Eritrocin;Eritrodes;Eritronicol;Eritropan;Eritroveinte;Eritrovienite;Eritrowolf;Eritro-wolf;Erymycin;Eryped;Ery-tar;Erythromictine;Erythro-prat;Ery-toxinal;Erytrodol;Erytro-prot;Eryt-toxinal;Espimina;Estimina;Estomiicina;Estomycin;Fesmicina;Ilosone pulvules;Ilosone ready-mix;Ilothycin;Kesso-mycin;Laucetin;Laurilin;Lauritran;Liferitrin;Loderm;Lubomycina;Lubomycine;Makrocyklina;Manilina;Marocid;Neo-ilolycina;Neo-iloticina;Niux;Novorythro;Propriocin enfante;Prospiocine;Proterytrin;Pulmomas;Purmycin;Ritromin;Roxo chemil;Roxochemil;Rp-mycin;Rubibacter;Selvicin;Spetrasone;Stella micina;Taimoxin;Togerin;Togrien;Tosinova;Tropoxin;Wyamycin s.

Therapeutic Function

Antibacterial

World Health Organization (WHO)

Erythromycin estolate, a macrolide antibiotic, was introduced in 1958 for the treatment of gram-positive infections. By the early 1970s its use had been associated with a higher incidence of hepatic toxicity than that seen with other salts and esters of erythromycin. This led to its withdrawal by some regulatory authorities whereas others required the addition of a warning in the product information. Evidence that the estolate ester is more hepatotoxic than other salts or esters has subsequently been disputed. It has been claimed to be the most effective ester for treatment of Legionnaire's disease and preparations remain widely available. (Reference: (BMJOAE) British Medical Journal, 286, 1954, 1983)

General Description

Erythromycin estolate, erythromycin propionate lauryl sulfate(Ilosone), is the lauryl sulfate salt of the 2＇-propionateester of erythromycin. Erythromycin estolate is acid stableand absorbed as the propionate ester. The ester undergoesslow hydrolysis in vivo. Only the free base binds to bacterialribosomes. Some evidence, however, suggests that theester is taken up by bacterial cells more rapidly than thefree base and undergoes hydrolysis by bacterial esteraseswithin the cells. The incidence of cholestatic hepatitis is reportedlyhigher with the estolate than with other erythromycinpreparations.
Erythromycin estolate occurs as long needles that aresparingly soluble in water but soluble in organic solvents. administration for the treatment of serious infections,such as Legionnaires disease, or when oral administrationis not possible. Solutions are stable for 1 week whenrefrigerated.

Erythromycin Estolate Preparation Products And Raw materials

Raw materials

Sodium dodecyl sulfate Acetone Propionic anhydride Erythromycin Sodium Lauryl Sulfate

Preparation Products

2-(4-chlorop henyl)-4，5-dihydro-1-methyl-5-(trifluoromethyl)-1H-pyr role-3-carbonitrile ROKITAMYCIN Zopiclone Pipecuronium bromide Disperse Yellow HG

DL-Histidine L-Isoleucine Ozagrel 2-cyano-N-[(ethylamino)carbonyl]acetamide disodium 5-((4-acetylamino-2-sulphophenyl)azo)-6-amino-4-hydroxynaphthalene-2-disulphonate

azafenidin DL-Tyrosine polybenzo conductive polymer materials PGA and its copolymer Acetylcholine chloride

Nilvadipine N-Hydroxymethyl-3,4,5,6-tetrahydrophthalimide

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Erythromycin Estolate Suppliers

Global( 378)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3791	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD	+8615377521700	wangwendy93@gmail.com	China	868	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Xiamen AmoyChem Co., Ltd	58
Chongqing Chemdad Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
SIMAGCHEM CORP	58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from Erythromycin Estolate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-16	Erythromycin Estolate 3521-62-8	US $0.00 / KG	100g	98%+	100kg	WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2023-06-15	Erythromycin Estolate 3521-62-8	US $215.00 / KG	1KG	98%	1-10mt	Baoji Guokang Bio-Technology Co., Ltd.
2022-02-25	Erythromycin Estolate 3521-62-8	US $10.00 / Kg/Bag	1KG	99%	10Tons	Hebei Senko Biotechnology Co., Ltd.

Erythromycin Estolate
3521-62-8
US $0.00 / KG
98%+
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Erythromycin Estolate
3521-62-8
US $215.00 / KG
98%
Baoji Guokang Bio-Technology Co., Ltd.

Erythromycin Estolate
3521-62-8
US $10.00 / Kg/Bag
99%
Hebei Senko Biotechnology Co., Ltd.

Erythromycin Estolate Spectrum

Erythromycin Estolate(3521-62-8)IR1 Erythromycin Estolate(3521-62-8)IR2

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ERYTHROMYCIN A DIHYDRATE 3-METHOXYETHOXYPROPYLAMINE Ammonium lauryl sulfate 1-AMINO-3,3-DIETHOXYPROPANE (S)-3-Hydroxy Myristic Acid

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erythromycinpropionatelaurylsulfate ERYTHROMYCIN ESTOLATE ERYTHROMYCIN 2'-PROPANOATE DODECYL SULFATE SALT ERYTHROMYCIN 2'-PROPIONATE DODECYL SULFATE ERYTHROMYCIN 2-PROPIONATE DODECYL SULFATE [4-DIMETHYLAMINO-2-[[14-ETHYL-7,12,13-TRIHYDROXY-4-(5-HYDROXY-4-METHOXY-4,6-DIMETHYL-OXAN-2-YL)OXY-3,5,7,9,11,13-HEXAMETHYL-2,10-DIOXO-1-OXACYCLOTETRADEC-6-YL]OXY]-6-METHYL-OXAN-3-YL] PROPANOATE, 1-SULFOOXYDODECANE Erythromycin Estolate BP Erythromycin Estolate I.P/Bp ERYTHROMYCIN ESTOLATE USP(CRM STANDARD) ERYTHROMYCIN ESTOLATE EPE(CRM STANDARD) ErythromycinEstolate-Bp/Ep/Usp ErythromycinEstolateErythromycinEstolateBp/Usp ERYTHROMYCINESTOLATE,USP Eriscel Erythromycin, 2'-propionate, dodecyl sulfate (salt) (8CI) Erythromycin, monopropanoate (ester), dodecyl sulfate (salt) Erythromycin, monopropionate (ester), compd. with monododecyl sulfate (1:1) Erythromycin, propionate, compd. with dodecyl sulfate (7CI) Erytrarco Estomicina Eupragin Lubomycine B Marcoeritrex NSC 263364 Propiocine Enfant Propionic acid, 2'-ester with erythromycin, dodecyl sulfate salt (6CI) Propionylerythromycin lauryl sulfate erythromycinpropionyllaurylsulfate lauromicina laurylsulfatepropionylerythromycinester neo-erycinum roxomicina stellamicina Sulfuric acid, monododecyl ester, compd. with erythromycin 2'-propanoate (1:1) (9CI) Sulfuric acid, monododecyl ester, compd. with erythromycin 2'-propionate (1:1) (8CI) Togiren ERYTHROMYCINPROPIONATELAURYLSULPHATE [4-Dimethylamino-2-[[(3R,4S,6R,7R,9R,11R,12R,13R,14R)-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-1-oxacyclotetradec-6-yl]oxy]-6-methyl-oxan-3-yl] propanoate 1-sulfooxydodecane Erythromycin estorate Erythro* Estolate Erythromycin 2'-prop Erythromycin Estolate (200 mg) ErythroMycin Estolate API eritroger eromycin erythromycin,propionate(ester),compd.withmonododecylsulfate(1:1) erythromycin5-(3-propionate)dodecylsulfate erythromycinpropionate,compd.withdodecylsulfate Relying on erythromycin Erytromycin ,Ilosone, Lauromycin, Laurylin, Propiocin, Ritromin Erythromycin estolate CRS (2S,3R,4S,6R)-4-(Dimethylamino)-2-(((3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-2,10-dioxooxacyclotetradecan-6-yl)oxy)-6-methyltet Erythromycin Estolate USP/EP/BP Erythromycin Estolate (1243002) propanoic acid [(2S,3R,4S,6R)-4-(dimethylamino)-2-[[(3R,4S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-[[(2S,4S,5R,6R)-5-hydroxy-4-methoxy-4,6-dimethyl-2-oxanyl]oxy]-3,5,7,9,11,13-hexameth Erythromycin Estolate Usp30 Phtalic anhydride ilosone