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o-Anisidine

o-Anisidine
o-Anisidine structure
CAS No.
90-04-0
Chemical Name:
o-Anisidine
Synonyms
nsc3122;ai3-08584;O-ANISOLE;2-Anisidin;O-ANISIDINE;2-ANISIDINE;o-Amnoanisde;O-AMINOANISOLE;2-AMINOANISOLE;ORTHO ANISIDINE
CBNumber:
CB1286995
Molecular Formula:
C7H9NO
Formula Weight:
123.15
MOL File:
90-04-0.mol

o-Anisidine Properties

Melting point:
3-6 °C(lit.)
Boiling point:
225 °C(lit.)
Density 
1.092 g/mL at 25 °C(lit.)
vapor pressure 
<0.1 at 25 °C (NIOSH, 1994)
refractive index 
n20/D 1.574(lit.)
Flash point:
210 °F
storage temp. 
Refrigerator
solubility 
14g/l
pka
4.52(at 25℃)
form 
Powder/Solid
color 
Off-white
PH
7.3 (1g/l, H2O, 20℃)
Water Solubility 
13 g/L (20 ºC)
Sensitive 
Light Sensitive
Merck 
14,667
BRN 
386210
Henry's Law Constant
1.25 at 25 °C (approximate - calculated from water solubility and vapor pressure)
Exposure limits
Potential occupational carcinogen. NIOSH REL: TWA 0.5 mg/m3, IDLH 50 mg/m3; OSHA PEL: TWA 0.5 mg/m3; ACGIH TLV: TWA 0.1 ppm (adopted).
Stability:
Stable. Incompatible with strong oxidizing agents, acid anhydrides, chloroformates, acids, some plastics, rubber. Air sensitive.
InChIKey
VMPITZXILSNTON-UHFFFAOYSA-N
CAS DataBase Reference
90-04-0(CAS DataBase Reference)
EWG's Food Scores
5
FDA UNII
NUX042F201
Proposition 65 List
o-Anisidine
IARC
2A (Vol. Sup 7, 73, 127)
NIST Chemistry Reference
Benzenamine, 2-methoxy-(90-04-0)
EPA Substance Registry System
o-Anisidine (90-04-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H320-H351-H371-H373-H401-H301+H311+H331-H341-H350-H301-H311-H331
Precautionary statements  P301+P310a-P501a-P201-P261-P280-P301+P310-P311-P202-P260-P264-P270-P271-P273-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P305+P351+P338+P337+P313-P308+P311-P403+P233-P405-P501
Hazard Codes  T,Xi
Risk Statements  45-23/24/25-68
Safety Statements  53-45
RIDADR  UN 2431 6.1/PG 3
WGK Germany  3
RTECS  BZ5410000
8
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29222200
Toxicity Acute oral LD50 for rats 2,000 mg/kg, wild birds 422 mg/kg, mice 1,400 mg/kg, rabbits 870 mg/kg (quoted, RTECS, 1985).
NFPA 704
1
0

o-Anisidine price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A88182 o-Anisidine ≥99% 90-04-0 5g $26.7 2021-03-22 Buy
Sigma-Aldrich 31597 o-Anisidine analytical standard 90-04-0 250mg $46.1 2021-03-22 Buy
TCI Chemical A0486 o-Anisidine >98.0%(GC)(T) 90-04-0 25mL $24 2021-03-22 Buy
TCI Chemical A0486 o-Anisidine >98.0%(GC)(T) 90-04-0 500mL $111 2021-03-22 Buy
Alfa Aesar A10288 o-Anisidine, 99% 90-04-0 1000g $96.4 2021-03-22 Buy

o-Anisidine Chemical Properties,Uses,Production

Description

o-Anisidine was produced commercially in the United States from the 1920s until late 1950s. By 2009, worldwide only six industries manufactured o-anisidine, but none produced hydrochloride salt. o-Anisidine was available from 44 suppliers, including 20 US suppliers, and the hydrochloride salt was available from eight suppliers, including five US suppliers. US imports of o-anisidine and its hydrochloride salt are reported in the category ‘o-anisidines, p-anisidines, and p-phenetidine,’ and US exports are reported in the category ‘anisidines, dianisidines, phenetidines, and their salts.’ From 1989 to 2008, imports ranged from a high of over 4.6 million kg in 1996 to zero in 2007 and 2008, and exports ranged from zero to 262 000 kg. Reports filed under the US Environmental Protection Agency’s (EPA) Toxic Substances Control Act Inventory Up Rule indicated that United States production plus imports of o-anisidine totaled 500 000 lb–1 million lb in 1986, 1990, and 2006; 1 million–10 million lb in 1990 and 1998; and 10 000–500 000 lb in 2002.

Chemical Properties

Anisidine exists as ortho-, meta-, and paraisomers. They have characteristic amine (fishy) odors.
o-Anisidine (or o-methoxyaniline) is an aromatic amine with a methoxyl group ortho to the amino group of aniline. It is a colorless to yellowish, pink, or reddish liquid.o-Anisidine is soluble in water and mineral oils, and miscible with alcohol, benzene, acetone, and diethylether. o-Anisidine hydrochloride, a salt of o-anisidine, is a grayish crystalline solid or powder at room temperature and is soluble in water (NTP, 2011).

Physical properties

Colorless, yellow to reddish liquid with an amine-like odor. Becomes brown on exposure to air.

Uses

Similar to other aromatic amines, o-anisidine may cause methemglobinemia and cancer in humans. It is used mainly as an intermediate for the production of azo dyes and pigments. Other industrial uses of o-anisidine include synthesis of other dyes and pharmaceuticals, as a corrosion inhibitor for steel, and as an antioxidant for polymercaptan resins (IARC, 1999; HSDB, 2012).
Intermediate for azo dyes and for guaiacol.

Uses

In the preparation of azo dyes; corrosion inhibitor; chemical intermediate

Uses

It is primarily used as a chemical intermediate in the production of pigments, dyes, pharmaceuticals, and fragrances. o-Anisidine hydrochloride is used as a chemical intermediate in the production of numerous azo and triphenylmethane dyes and pigments (e.g., C.I. direct red 72, disperse orange 29, direct yellow 44, direct red 24, and acid red 4); in the production of pharmaceuticals, including the expectorant guaiacol; as a corrosion inhibitor for steel; and as an antioxidant for polymercaptan resins.

Synthesis Reference(s)

Tetrahedron Letters, 24, p. 4733, 1983 DOI: 10.1016/S0040-4039(00)86242-5

General Description

Clear, yellowish to reddish or brown liquid with an amine (fishy) odor.

Air & Water Reactions

o-Anisidine darkens on exposure to air. Insoluble in water.

Reactivity Profile

o-Anisidine is sensitive to heat. o-Anisidine is also sensitive to exposure to light. o-Anisidine is incompatible with strong oxidizers. o-Anisidine is also incompatible with acids, acid chlorides, acid anhydrides and chloroformates. o-Anisidine will attack some forms of plastics, rubber and coatings. .

Hazard

Strong irritant. Toxic when absorbed through the skin. Possible carcinogen.

Health Hazard

o-Anisidine was carcinogenic in experimental animals.

Fire Hazard

o-Anisidine is combustible.

Safety Profile

Confirmed carcinogen. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

Anisidines are used in the manufacture of azo dyes; pharmaceuticals; textile-processing chemicals Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine,bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks some coatings and some forms of plastic and rubber.

Carcinogenicity

o-Anisidine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity in experimental animals.

Environmental Fate

Biological. o-Anisidine should be biodegradable according to OECD guidelines (Brown and Labouerer (1983). Chemical/Physical. At influent concentrations (pH 3.0) of 10, 1.0, 0.1, and 0.01 mg/L, the GAC adsorption capacities were 52, 20, 7.8, and 3.0 mg/g, respectively. At pHs 7 and 9, the GAC adsorption capacities were 110, 50, 23, and 10 mg/g at influent concentrations of 10, 1.0, 0.1, and 0.01 mg/L, respectively (Dobbs and Cohen, 1980).

Shipping

UN2431 Anisidines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Purification Methods

It is separated from the m-and p-isomers by steam distillation. It is also separated from its usual synthetic precursor o-nitroanisole by dissolving it in dilute HCl (pH <2.0) extracting the nitro impurity with Et2O, adjusting the pH to ~8.0 with NaOH, extracting the amine into Et2O or steam distilling. Extract the distillate with Et2O, dry the extract (Na2SO4), filter, evaporate and fractionate the residual oil. Protect the almost colourless oil from light which turns it yellow in color. [Biggs & Robinson J Chem Soc 3881961, Nodzu et al. Yakugaku Zasshi (J Pharm Soc Japan) 71 713, 715 1951, Beilstein 13 IV 806.]

Toxicity evaluation

It is primarily metabolized by cytochrome P450 isozymes, and it forms two o-anisidine–DNA adducts with DNA. It causes DNA damage by a metabolite in the presence of metals such as Cu(II). It can also cause Cu(II)-mediated oxidative DNA damage.

Waste Disposal

Dissolve in combustible solvent (alcohols, benzene, etc.) and spray solution into furnace equipped with afterburner and scrubber, or burn spill residue on sand and soda ash absorbent in a furnace.

o-Anisidine Preparation Products And Raw materials

Raw materials

Preparation Products


o-Anisidine Suppliers

Global( 293)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20907 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26762 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14344 58

View Lastest Price from o-Anisidine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-12 o-Anisidine
90-04-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-04-26 o-Anisidine
90-04-0
US $10.00 / PCS 1KG 99% 100 mt Hebei Guanlang Biotechnology Co., Ltd.
2020-01-03 o-Anisidine
90-04-0
US $1.00 / KG 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd

o-Anisidine Spectrum


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