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5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
CAS No.
89-25-8
Chemical Name:
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
Synonyms
PMP;NSC-12;Radicu;MCI-186;Radicut;NSC-2629;EDARAVONE;NSC-26139;Adaravone;developerz
CBNumber:
CB1287462
Molecular Formula:
C10H10N2O
Formula Weight:
174.2
MOL File:
89-25-8.mol

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Properties

Melting point:
126-128 °C(lit.)
Boiling point:
287 °C265 mm Hg(lit.)
Density 
1,12 g/cm3
refractive index 
1.6300 (estimate)
Flash point:
191°C/17mm
storage temp. 
Store at RT
solubility 
3.30g/l
form 
Crystalline Powder
color 
Yellow to beige
PH
4.0-4.4 (H2O, 20℃)(saturated aqueous solution)
Water Solubility 
3 g/L (20 ºC)
Merck 
14,6713
BRN 
609575
InChIKey
QELUYTUMUWHWMC-UHFFFAOYSA-N
CAS DataBase Reference
89-25-8(CAS DataBase Reference)
NIST Chemistry Reference
3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-(89-25-8)
EPA Substance Registry System
3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl- (89-25-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  1
RTECS  UQ9625000
TSCA  Yes
HS Code  29331990
Hazardous Substances Data 89-25-8(Hazardous Substances Data)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 443300 MCI-186 89-25-8 500mg $75.2 2018-11-20 Buy
Sigma-Aldrich 1040016 Antipyrine Related Compound A United States Pharmacopeia (USP) Reference Standard 89-25-8 25mg $1220 2018-11-13 Buy
TCI Chemical M0687 3-Methyl-1-phenyl-5-pyrazolone >98.0%(HPLC)(T) 89-25-8 25g $18 2018-11-22 Buy
TCI Chemical M0687 3-Methyl-1-phenyl-5-pyrazolone >98.0%(HPLC)(T) 89-25-8 500g $40 2018-11-22 Buy
Alfa Aesar A11161 3-Methyl-1-phenyl-2-pyrazolin-5-one, 98+% 89-25-8 100g $17.8 2018-11-13 Buy

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Chemical Properties,Uses,Production

Chemical Properties

Off white to light yellow powder

Uses

antioxidant, lipoxygenase inhibitor

Uses

Edaravone inhibits the disease activity in rheumatoid arthritis.

Definition

ChEBI: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.

Hazard

Toxic by ingestion.

Biological Activity

A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity.

Purification Methods

Crystallise the pyrazolone from hot H2O, EtOH or EtOH/water (1:1). It complexes with metals. [Veibel et al. Acta Chim Scand 6 1066 1952, Beilstein 24 II 9, 24 III/IV 71.]

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Preparation Products And Raw materials

Raw materials

Preparation Products


5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Suppliers

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View Lastest Price from 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-07 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
89-25-8
US $1.00 / KG 1KG 99% Customized

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Spectrum


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