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5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one structure
CAS No.
89-25-8
Chemical Name:
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
Synonyms
PMP;Radicu;NSC-12;Radicut;MCI-186;NSC-2629;Adaravone;EDARAVONE;NSC-26139;developerz
CBNumber:
CB1287462
Molecular Formula:
C10H10N2O
Formula Weight:
174.2
MOL File:
89-25-8.mol

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Properties

Melting point:
126-128 °C(lit.)
Boiling point:
287 °C265 mm Hg(lit.)
Density 
1,12 g/cm3
refractive index 
1.6300 (estimate)
Flash point:
191°C/17mm
storage temp. 
Store at RT
solubility 
3.30g/l
form 
Crystalline Powder
pka
2.73±0.50(Predicted)
color 
Yellow to beige
PH
4.0-4.4 (H2O, 20℃)(saturated aqueous solution)
Water Solubility 
3 g/L (20 ºC)
Merck 
14,6713
BRN 
609575
InChIKey
QELUYTUMUWHWMC-UHFFFAOYSA-N
CAS DataBase Reference
89-25-8(CAS DataBase Reference)
FDA UNII
S798V6YJRP
NIST Chemistry Reference
3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-(89-25-8)
EPA Substance Registry System
1-Phenyl-3-methyl-5-pyrazolone (89-25-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H303-H302-H315-H319-H335
Precautionary statements  P301+P312+P330-P305+P351+P338-P261
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  1
RTECS  UQ9625000
TSCA  Yes
HS Code  29331990
Toxicity LD50 orl-rat: 3500 mg/kg LONZA# 08FEB79

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 443300 MCI-186 89-25-8 500mg $75.2 2019-12-02 Buy
Sigma-Aldrich 1040016 Antipyrine Related Compound A United States Pharmacopeia (USP) Reference Standard 89-25-8 25mg $1212.75 2019-12-02 Buy
TCI Chemical M0687 3-Methyl-1-phenyl-5-pyrazolone >98.0%(HPLC)(T) 89-25-8 25g $18 2020-06-24 Buy
TCI Chemical M0687 3-Methyl-1-phenyl-5-pyrazolone >98.0%(HPLC)(T) 89-25-8 500g $38 2020-06-24 Buy
Alfa Aesar A11161 3-Methyl-1-phenyl-2-pyrazolin-5-one, 98+% 89-25-8 500g $38.8 2020-06-24 Buy

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Chemical Properties,Uses,Production

Description

Edaravone was marketed in Japan for improving neurologic recovery following acute brain infarction. Currently, several agents classified as neuroprotectants and acting by diverse mechanisms (inhibition of glutamate release, blockade of calcium channels, lazaroids) have been marketed for treating the outcomes of brain damage due to trauma, ischemia or cardiac arrest. Edavarone is the first antioxidant with free radical scavenging activity to be introduced for this pathology. This previously described molecule (in particular as norantipyrine, one of three metabolites of antipyrine in mammals) can be simply prepared by direct cyclization of phenylhydrazine with alkylacetoacetate. Edarevone is a lipophilic agent, readily accessible to brain tissue, that is capable of reducing edema in the brain following ischemia by blocking the arachidonic acid cascade triggering peroxidative neurodegeneration. Interestingly, this agent has been shown to quench active oxygen species in endothelial cell homogenate, as well as inhibiting in vitro lipid peroxidative disintegration of membranes, so making this compound effective during reperfusion following ischemic injury. As an additional indication, phase III trials started with edaravone for increasing the chance of recovery after subarachnoid hemorrhage.

Chemical Properties

Off white to light yellow powder

Originator

Mitsubishi Pharma (Japan)

Uses

antioxidant, lipoxygenase inhibitor

Uses

Edaravone inhibits the disease activity in rheumatoid arthritis.

Definition

ChEBI: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.

brand name

Radicut

Hazard

Toxic by ingestion.

Biological Activity

A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity.

Safety Profile

Moderately toxic by ingestion andintraperitoneal routes. An eye irritant. When heated todecomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise the pyrazolone from hot H2O, EtOH or EtOH/water (1:1). It complexes with metals. [Veibel et al. Acta Chim Scand 6 1066 1952, Beilstein 24 II 9, 24 III/IV 71.]

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Preparation Products And Raw materials

Raw materials

Preparation Products


5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Suppliers

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View Lastest Price from 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-06-28 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
89-25-8
US $667.00 / KG 1KG 98% 1T Shaanxi Dideu Medichem Co. Ltd
2020-06-28 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
89-25-8
US $667.00 / KG 1KG 98% 1T Shaanxi Dideu Medichem Co. Ltd
2019-04-04 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
89-25-8
US $6.00 / kg 1kg High quality Professional Factory Ms Ella chemwill_asia@126.com www.chemwill.com Chemwill Asia Co.,Ltd.

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Spectrum


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