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Nicorandil

Nicorandil
Nicorandil
CAS No.
65141-46-0
Chemical Name:
Nicorandil
Synonyms
SG-75;IKOREL;Dancor;ADANCOR;SIGMART;Zynicor;PERISALOL;NICORANDIL;Nicorandil(Ikorel);2-nicotinamidoethylnitrate
CBNumber:
CB1291140
Molecular Formula:
C8H9N3O4
Formula Weight:
211.17
MOL File:
65141-46-0.mol

Nicorandil Properties

Melting point:
92°C
Boiling point:
350.85°C (rough estimate)
Density 
1.4271 (rough estimate)
refractive index 
1.7400 (estimate)
RTECS 
US4667600
storage temp. 
Desiccate at +4°C
solubility 
DMSO: >10mg/mL
pka
pKa 空 (Uncertain)
form 
powder
color 
white to off-white
Merck 
14,6521
CAS DataBase Reference
65141-46-0
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-41
Safety Statements  26-39
WGK Germany  3
HS Code  29333990
Toxicity LD50 in rats (mg/kg): 1200-1300 orally; 800-1000 i.v. (Nagano)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Nicorandil price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N3539 Nicorandil ≥98% (HPLC) 65141-46-0 50mg $66.9 2018-11-13 Buy
Sigma-Aldrich N3539 Nicorandil ≥98% (HPLC) 65141-46-0 250mg $269 2018-11-13 Buy
TCI Chemical N0837 Nicorandil >98.0%(HPLC)(T) 65141-46-0 100mg $60 2018-11-22 Buy
TCI Chemical N0837 Nicorandil >98.0%(HPLC)(T) 65141-46-0 1g $178 2018-11-22 Buy
Alfa Aesar J60879 Nicorandil, 98+% 65141-46-0 1g $221 2018-11-13 Buy

Nicorandil Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

An antianginal

Uses

Antihypertensor

Definition

ChEBI: A pyrimidinecarboxamide that is nicotinamide in which one of the hydrogens attached to the carboxamide nitrogen is replaced by a 2-(nitrooxy)ethyl group. It has both nitrate-like and ATP-sensitive potassium channel activator properties, and is used for the prevention and treatment of angina pectoris.

Biological Activity

K ATP channel opener and NO donor, clinically used as antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing K ATP channels (EC 50 values are 10 and > 500 mM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.

Nicorandil Preparation Products And Raw materials

Raw materials

Preparation Products


Nicorandil Suppliers

Global( 171)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
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Henan DaKen Chemical CO.,LTD.
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Henan Tianfu Chemical Co.,Ltd.
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Shanghai Time Chemicals CO., Ltd.
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+86-021-57951555 jack.li@time-chemicals.com CHINA 1374 55
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TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
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