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Enalapril

Enalapril structure

CAS No.: 75847-73-3

Chemical Name:: Enalapril

Synonyms: Vasotec;Renitec;G1ioten;Hipoartd;ENALAPRIL;Enalapril hydrate;Enalapril (MK-421);ELAPRILAT DIHYDRAT;Enalapril USP/EP/BP;Enalapril AldrichCPR

CBNumber:: CB1295108

Molecular Formula:: C20H28N2O5

Molecular Weight:: 376.45

MDL Number:: MFCD00865774

MOL File:: 75847-73-3.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:11

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Enalapril Properties

Melting point	142-147℃
Boiling point	582.4±50.0 °C(Predicted)
Density	1.204±0.06 g/cm3(Predicted)
RTECS	TW3665500
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Soluble in DMSO
form	Powder
pka	pKa 2.97 (H2O t=25.0)(Approximate);5.35(H2O t=25.0)(Approximate)
Water Solubility	Soluble in water at 25mg/ml
BCS Class	3
CAS DataBase Reference	75847-73-3(CAS DataBase Reference)
NCI Dictionary of Cancer Terms	enalapril
FDA UNII	69PN84IO1A
NCI Drug Dictionary	Vasotec
ATC code	C09AA02
EPA Substance Registry System	L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl- (75847-73-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Warning
Hazard statements	H317-H361
Precautionary statements	P280
Safety Statements	22-24/25
WGK Germany	3

Enalapril price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Alfa Aesar	J60750	Enalapril	75847-73-3	1g	$93.65	2024-03-01	Buy
Alfa Aesar	J60750	Enalapril	75847-73-3	5g	$369.65	2024-03-01	Buy
Cayman Chemical	16041	Enalapril ≥98%	75847-73-3	5g	$165	2021-12-16	Buy
Cayman Chemical	16041	Enalapril ≥98%	75847-73-3	1g	$48	2021-12-16	Buy
Cayman Chemical	16041	Enalapril ≥98%	75847-73-3	10g	$270	2021-12-16	Buy

Product number	Packaging	Price	Buy
J60750	1g	$93.65	Buy
J60750	5g	$369.65	Buy
16041	5g	$165	Buy
16041	1g	$48	Buy
16041	10g	$270	Buy

Enalapril Chemical Properties,Uses,Production

Uses

It is used for hypertension and chronic cardiac insufficiency.

Uses

angiotensin converting enzyme inhibitor

Uses

Enalapril is used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. It has been proven to protect the function of the kidneys in hypertension, heart failure, and diabetes, and may be used in the absence of hypertension for its kidney protective effects. It is widely used in chronic kidney failure.

Definition

ChEBI: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).

Mechanism of action

Like captopril, enalapril selectively suppresses the rennin–angiotensin–aldosterone system, inhibits angiotensin-converting enzyme, and prevents conversion of angiotensin I into angiotensin II.

Synthesis

Enalapril, (S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline (22.7.12), is synthesized by reacting the benzyl ester of L-alanyl-L-proline with the ethyl ester of 3-benzoylacrylic acid, which forms the product 22.7.11, the reduction of which with hydrogen using a Raney nickel catalyst removes the protective benzyl group, giving the desired enalapril (22.7.12) [24]. Alternative methods of syntheses have also been proposed.

Synthesis_75847-73-3

Enalapril synthesis

Synthesis of Enalapril from Ethyl 2-oxo-4-phenylbutyrate and L-Alanyl-L-proline

Enalapril Preparation Products And Raw materials

Raw materials

N-Hydroxysuccinimide Enalapril maleate Palladium carbon fine chemical catalyzer Benzyl ester Ethyl 2-oxo-4-phenylbutyrate

Maleic acid CIS-BUTENEDIOIC ANHYDRIDE PROPYLENE dipeptide L-Alanyl-L-proline

Water L-Proline Bromobenzene Concentrated sulfuric acid Benzene

Ethyl acetate D-Alanine Acetic acid Ethyl acrylate DOWEX(R) 50WX4 HYDROGEN FORM

Sodium cyanoborohydride Dicyclohexylcarbodiimide Formamide

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Preparation Products

Enalapril Suppliers

Global( 184)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangxi Huihe Chemical Co., Ltd.	+86-19189228086 +8618858568638	wuzhouding@huihecrop.com	China	886	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	mcbio_sales@163.com	China	2255	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9320	58
Hebei Lingding Biotechnology Co., Ltd.	+86-18031140164 +86-19933155420	erin@hbldbiotech.com	China	878	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58

Supplier	Advantage
Jiangxi Huihe Chemical Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
Xi'an MC Biotech, Co., Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Lingding Biotechnology Co., Ltd.	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from Enalapril manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-10-20	Enalapril 75847-73-3	US $200.00 / KG	1KG	99%	9000kg/per week	Hebei Lingding Biotechnology Co., Ltd.
2021-08-12	Enalapril 75847-73-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-13	Enalapril 75847-73-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Enalapril
75847-73-3
US $200.00 / KG
99%
Hebei Lingding Biotechnology Co., Ltd.

Enalapril
75847-73-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Enalapril
75847-73-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

75847-73-3(Enalapril)Related Search:

cis-4-Hydroxy-L-proline Ethyl acrylate L-PROLINE-(4-3H(N)) Ethylbenzene Ethylparaben

D-Proline Tris(trimethylsilyl)phosphate Ethanol Ethyl acetate ENALAPRILAT-D5

ENALAPRILAT-D5, SODIUM SALT Trandolapril Indolapril N2-1[(1S)-Ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysyl-L-proline Spirapril

Enalapril maleate Diethyl ether Enalapril-D5 tert-Butyl Ester

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ENALAPRIL (s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-proline 1-(n-((s)-1-carboxy-3-phenylpropyl)-l-alanyl)-l-proline 1'-ethyl ester 1-[2-(1-ETHOXYCARBONYL-3-PHENYL-PROPYL)AMINOPROPANOYL]PYRROLIDINE-2-CARBOXYLIC ACID Renitec Enalapril Maleate USP24 L-Proline, 1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-, (S)- L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl- (-)-1-[N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline 1-[N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro-OH N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro-OH (S)-1-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)aMino)propanoyl)pyrrolidine-2-carboxylic acid Enalapril AldrichCPR (S)-1-[N-[1-(Ethoxyearbonyl)-3-phenylpropyl]-L-alanyl]-L-proline G1ioten Hipoartd (2S)-1-[(2S)-2-[[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid (S)-N-[1-Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline Enalapril hydrate Enalapril USP/EP/BP Enalaprilat dihydrat EnalaprilQ: What is Enalapril Q: What is the CAS Number of Enalapril Q: What is the storage condition of Enalapril Q: What are the applications of Enalapril Vasotec Enalapril (MK-421) ELAPRILAT DIHYDRAT 75847-73-3 C20H28N2O5 Angiotensin