Nebivolol
- CAS No.
- 99200-09-6
- Chemical Name:
- Nebivolol
- Synonyms
- R-65824;Nebivolol;Nibivolol;NEBIVOLOL-D4;NEBIVOLOL-D6;(Rac)-Nebivolol;Nebivolol (10mM in DMSO);rac-Nebivolol (Mixture of Diastereomers);2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol);2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethan-1-ol)
- CBNumber:
- CB1295698
- Molecular Formula:
- C22H25F2NO4
- Molecular Weight:
- 405.43
- MDL Number:
- MFCD00865796
- MOL File:
- 99200-09-6.mol
| Boiling point | 600.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.309±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 14.29±0.20(Predicted) |
| color | White to Off-White |
| InChIKey | KOHIRBRYDXPAMZ-AWIIVWKDNA-N |
| SMILES | C([2H])([2H])([C@H](O)[C@@]1([H])CCC2C=C(C=CC=2O1)F)NC([2H])([2H])[C@H](O)[C@]1([H])CCC2C=C(C=CC=2O1)F |&1:3,5,21,23,r| |
| CAS DataBase Reference | 99200-09-6(CAS DataBase Reference) |
| FDA UNII | 030Y90569U |
Nebivolol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | N387933 | Nebivolol | 99200-09-6 | 10mg | $180 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | ND34423 | (S,R,R,R)-Nebivolol-d2,15Nhydrochloride | 99200-09-6 | 5mg | $1690 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0031361 | NEBIVOLOL 95.00% | 99200-09-6 | 100G | $5699.93 | 2021-12-16 | Buy |
| Ambeed | A753261 | 2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol) 98% | 99200-09-6 | 100mg | $93 | 2021-12-16 | Buy |
| Ambeed | A753261 | 2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol) 98% | 99200-09-6 | 250mg | $170 | 2021-12-16 | Buy |
Nebivolol Chemical Properties,Uses,Production
Description
Nebilet was launched in Germany and the Netherlands as an antihypertensive agent. It is prepared by a five step route starting with 6-fluoro-4- oxobenzopyran-2-carboxylic acid. It is a selective β1-adrenergic receptor antagonist and is 50 times less potent at β2-receptors. Vasodialating properties occur via the nitric oxide pathway. While the L-isomer is more potent than the D-isomer, the racemic mixture is necessary for optimal activity. Upon administration, an immediate fall in blood pressure occurs, it improves both left ventricular systolic and diastolic function, and lowers peripheral blood resistance. Nebilet does not influence insulin sensitivity nor lipid profile comparible to atenolol. Doses of 50 mg of atenolol and 10 mg of Nebilet are equipotent but Nebilet has a longer duration of action due to an accumulation of the drug and increasing plasma levels of active metabolites.
Originator
Johnson & Johnson (US)
Uses
Labeled Nebivolol, intended for use as an internal standard for the quantification of Nebivolol by GC- or LC-mass spectrometry.
Uses
Nebivolol is a cardioselective beta-1 receptor blocking agent.
Definition
ChEBI: A member of the class of chromanes that is 2,2'-iminodiethanol in which one hydrogen attached to each hydroxy-bearing carbon is replaced by a 6-fluorochroman-2-yl group.
brand name
Nebilet
Nebivolol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Casorganics US Corp | +17326109938 | sales@casorganics.com | CHINA | 174 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5601 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5791 | 58 |
View Lastest Price from Nebivolol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-05-11 | Nebivolol
99200-09-6
|
US $0.00-0.00 / G | 1G | 99%HPLC | 100KG | Senova Technology Co. Ltd. | |
 |
2022-02-18 | nebivolol
99200-09-6
|
US $0.00 / gram | 1gram | 99% | 10kg | Zhejiang J&C Biological Technology Co.,Limited | |
 |
2021-08-12 | Nebivolol
99200-09-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |