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Progabide

Progabide
Progabide structure
CAS No.
62666-20-0
Chemical Name:
Progabide
Synonyms
Gabren;Gabrene;SL-76.002;progabide;Halogabide;C-abren(e);4-[α-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino]butyramide;4-[[(4-Chlorophenyl)(5-fluoro-2hydroxyphenyl)methylene]amino]butanamide;(E)-4-((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyleneamino)butanamide;BUTANAMIDE, 4-[[(4-CHLOROPHENYL)(5-FLUORO-2-HYDROXYPHENYL)METHYLENE]AMINO]-
CBNumber:
CB1296044
Molecular Formula:
C17H16ClFN2O2
Formula Weight:
334.77
MOL File:
62666-20-0.mol

Progabide Properties

Melting point:
133-135°; mp 142.5° (Kaplan, J. Med. Chem.)
Boiling point:
525.4±50.0 °C(Predicted)
Density 
1.2822 (estimate)
pka
pKa 3.41 ± 0.04(0.4% MeOH,t=37,Iundefined)(Approximate)
Water Solubility 
37.16mg/L(37 ºC)
FDA UNII
38C836J57Z
SAFETY
  • Risk and Safety Statements
Toxicity LD50 i.p. in mice: 900 mg/kg (Kaplan)

Progabide Chemical Properties,Uses,Production

Description

Progabide is a broad-spectrum anticonvulsant agent indicated for the treatment of a wide variety of seizure disorders. Synthesized as a GABA-prodrug, anticonvulsant activity appears due to the parent drug and its acid metabolite, as well as to GABAmide and GABA liberated therefrom.

Chemical Properties

Bright Yellow Solid

Originator

Synthelabo (France)

Uses

Progabide is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity.

brand name

Gabren (Synthelabo Pharmacie, France);Gabaphore;Sl 76 002;GABRENE.

World Health Organization (WHO)

Progabide, an anticonvulsant, was introduced in France in 1985 for the treatment of epilepsy. Its use has occasionally been associated with clinically evident signs of icteric hepatitis developing within the first six months of treatment. These signs are generally reversible on withdrawal of the drug but continuation of treatment has been associated with three reported fatalities (two of which are doubtfully related to the drug). The manufacturer revised the data sheet in March 1986 advising that use of progabide should be reserved for patients unresponsive to other anticonvulsants.

Progabide Preparation Products And Raw materials

Raw materials

Preparation Products


Progabide Suppliers

Global( 33)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24754 60
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47486 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 132149 58
J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18
0086-571-85864795 sales@capotchem.com China 18228 66
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32358 50
Beijing HuaMeiHuLiBiological Chemical 010-56205725
010-65763397 waley188@sohu.com China 12341 58
ATK CHEMICAL COMPANY LIMITED 13301690235 021-5161-9050
+86-21-5161 9052,QQ526763801 Sales@ATKchemical.com China 10191 58
Shenzhen Regent Biochemical Technology Co., Ltd. 18938635012 0755-85201366-
0755-85201366 sales@regentsciences.com;sales@regentsciences.com China 9776 58
Angel Pharmatech, Ltd. 17317130613
3358272972@qq.com China 3121 58

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