Progabide
- CAS No.
- 62666-20-0
- Chemical Name:
- Progabide
- Synonyms
- Gabren;Gabrene;SL-76．002;progabide;Halogabide;C-abren(e);Progabide USP/EP/BP;4-[α-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino]butyramide;4-[[(4-Chlorophenyl)(5-fluoro-2hydroxyphenyl)methylene]amino]butanamide;(E)-4-((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyleneamino)butanamide
- CBNumber:
- CB1296044
- Molecular Formula:
- C17H16ClFN2O2
- Molecular Weight:
- 334.77
- MDL Number:
- MFCD01740869
- MOL File:
- 62666-20-0.mol
| Melting point | 133-135°; mp 142.5° (Kaplan, J. Med. Chem.) |
|---|---|
| Boiling point | 525.4±50.0 °C(Predicted) |
| Density | 1.2822 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly, Sonicated), DMSO, Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | pKa 3.41 ± 0.04(0.4% MeOH,t=37,Iundefined)(Approximate) |
| color | Light Yellow to Yellow |
| Water Solubility | 37.16mg/L(37 ºC) |
| CAS DataBase Reference | 62666-20-0 |
| FDA UNII | 38C836J57Z |
| ATC code | N03AG05 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Toxicity | LD50 i.p. in mice: 900 mg/kg (Kaplan) |
Progabide price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | P755350 | Progabide | 62666-20-0 | 100mg | $185 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FP103146 | Progabide | 62666-20-0 | 50mg | $200 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 48387 | Progabide | 62666-20-0 | 100mg | $650 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009296 | PROGABIDE 95.00% | 62666-20-0 | 100MG | $750.75 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FP103146 | Progabide | 62666-20-0 | 10mg | $80 | 2021-12-16 | Buy |
Progabide Chemical Properties,Uses,Production
Description
Progabide is a broad-spectrum anticonvulsant agent indicated for the treatment of a wide variety of seizure disorders. Synthesized as a GABA-prodrug, anticonvulsant activity appears due to the parent drug and its acid metabolite, as well as to GABAmide and GABA liberated therefrom.
Chemical Properties
Bright Yellow Solid
Originator
Synthelabo (France)
Uses
Progabide is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity.
Definition
ChEBI: Progabide is a diarylmethane.
brand name
Gabren (Synthelabo Pharmacie, France);Gabaphore;Sl 76 002;GABRENE.
World Health Organization (WHO)
Progabide, an anticonvulsant, was introduced in France in 1985 for the treatment of epilepsy. Its use has occasionally been associated with clinically evident signs of icteric hepatitis developing within the first six months of treatment. These signs are generally reversible on withdrawal of the drug but continuation of treatment has been associated with three reported fatalities (two of which are doubtfully related to the drug). The manufacturer revised the data sheet in March 1986 advising that use of progabide should be reserved for patients unresponsive to other anticonvulsants.
Progabide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | sales@capotchem.com | China | 18217 | 66 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | sales@regentsciences.com | China | 9288 | 58 |
View Lastest Price from Progabide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-23 | Progabide USP/EP/BP
62666-20-0
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Progabide USP/EP/BP
62666-20-0
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited