4-BROMOISATIN
- CAS No.
- 20780-72-7
- Chemical Name:
- 4-BROMOISATIN
- Synonyms
- 4-BROM;4-Broisatin;4-BROMOISATIN;4-Bromoisatin 98%;BUTTPARK 50\07-93;4-Bromoisatin >4- broMoindigo carMine;Fampridine Impurity 25;4-BROMOINDOLE-2,3-DIONE;4-BROMOINDOLINE-2,3-DIONE
- CBNumber:
- CB1301591
- Molecular Formula:
- C8H4BrNO2
- Molecular Weight:
- 226.03
- MDL Number:
- MFCD03618555
- MOL File:
- 20780-72-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Bromoisatin >98.0%(GC)(T) | B2423 | 5g | $41 |
| 4-Bromoisatin >98.0%(GC)(T) | B2423 | 25g | $116 |
| 4-Bromoisatin | B685523 | 2.5g | $75 |
| 4-Bromo-1H-indole-2,3-dione | J98505 | 100g | $130 |
| 4-Bromoisatin,≥98%(GC) ≥98%(GC) | 44526 | 5G | $34.26 |
| More product size | |||
| Melting point | 253-256 |
|---|---|
| Density | 1.826±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Dimethylformamide |
| form | powder to crystal |
| pka | 8.73±0.20(Predicted) |
| color | Light yellow to Brown |
| InChI | InChI=1S/C8H4BrNO2/c9-4-2-1-3-5-6(4)7(11)8(12)10-5/h1-3H,(H,10,11,12) |
| InChIKey | ITRAKBJPMLKWIW-UHFFFAOYSA-N |
| SMILES | N1C2=C(C(Br)=CC=C2)C(=O)C1=O |
| CAS DataBase Reference | 20780-72-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
4-BROMOISATIN price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B2423 | 4-Bromoisatin >98.0%(GC)(T) | 20780-72-7 | 5g | $41 | 2025-07-31 | Buy |
| TCI Chemical | B2423 | 4-Bromoisatin >98.0%(GC)(T) | 20780-72-7 | 25g | $116 | 2025-07-31 | Buy |
| TRC | B685523 | 4-Bromoisatin | 20780-72-7 | 2.5g | $75 | 2021-12-16 | Buy |
| AK Scientific | J98505 | 4-Bromo-1H-indole-2,3-dione | 20780-72-7 | 100g | $130 | 2021-12-16 | Buy |
| Chem-Impex | 44526 | 4-Bromoisatin,≥98%(GC) ≥98%(GC) | 20780-72-7 | 5G | $34.26 | 2021-12-16 | Buy |
4-BROMOISATIN Chemical Properties,Uses,Production
Definition
ChEBI: 4-Bromoisatin is a member of indoles. It has a role as an anticoronaviral agent.
Synthesis
65971-74-6
6326-79-0
20780-72-7
The general procedure for the synthesis of 6-bromodihydroindole-2,3-diones and 4-bromoindoline-2,3-diones using 2-hydroxyimino-N-(3-bromophenyl)-acetamide as starting material is as follows: 1. to a solution of hydrogen chloride (50.0 g, 0.247 mol) in water (237 mL) was sequentially added a mixture of anhydrous sodium sulfate (69.0 g, 0.486 mol) and 3-bromoaniline (40.0 g, 0.233 mol) in 37% hydrochloric acid (25 mL). 2. Water (632 mL) was added slowly with vigorous stirring. After addition, the reaction mixture was heated to reflux for 10 minutes and then cooled to room temperature. 3. The precipitate formed was collected by filtration, washed with water (3 x 100 mL) and dried under vacuum to give crude isonitrosoacetanilide. 4. The crude product was added in batches to rapidly stirred concentrated sulfuric acid (790 mL), with the rate of addition controlled to maintain the reaction temperature between 50 and 70 °C. The reaction was carried out in a controlled manner. 5. The reaction mixture was heated to 80°C, held for 20 minutes, and then cooled to room temperature. 6. The cooled mixture was poured into crushed ice (about 320 g) and allowed to stand for 1 hour. 7. The orange precipitate was collected by filtration, washed with water and dried to give a mixture of 4-bromoindigo (K-98) and 6-bromoindigo (K-99) (40 g, 83% yield).
References
[1] Patent: WO2006/44415, 2006, A2. Location in patent: Page/Page column 118
[2] Synthetic Communications, 2010, vol. 40, # 21, p. 3125 - 3134
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 4, p. 935 - 946
[4] Journal of Medicinal Chemistry, 2001, vol. 44, # 26, p. 4641 - 4649
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 1, p. 18 - 36
4-BROMOISATIN Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20137 | 58 |
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +1-5184799099 | lbaochemicals@gmail.com | China | 619 | 58 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29847 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
View Lastest Price from 4-BROMOISATIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-06 | 4-Bromoisatin
20780-72-7
|
US $0.00 / kg | 1kg | 98% | Customise | Hefei Lbao Physical & Chemical Science Co.,Ltd | |
 |
2025-09-25 | 4-BROMOISATIN
20780-72-7
|
US $36.00-1.50 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2021-08-12 | 4-BROMOISATIN
20780-72-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 4-Bromoisatin
20780-72-7
- US $0.00 / kg
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- 4-BROMOISATIN
20780-72-7
- US $36.00-1.50 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-BROMOISATIN
20780-72-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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