Tenofovir alafenamide hemifumarate
- CAS No.
- 1392275-56-7
- Chemical Name:
- Tenofovir alafenamide hemifumarate
- Synonyms
- Tenofovir Alafenamide fumarate;GS7340(Tenofovir Alafenamide Fumarate);N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1);L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1);Anti-HIV;API-Anti-HBV;Tenofovir Alafenamid;GS-7340 (hemifumarate);Alafenamide hemifumarate;Tenofovir levamide amine fumarate
- CBNumber:
- CB13038481
- Molecular Formula:
- C25H33N6O9P
- Molecular Weight:
- 592.55
- MDL Number:
- MFCD30534429
- MOL File:
- 1392275-56-7.mol
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
---|---|
solubility | DMSO:75.0(Max Conc. mg/mL);70.16(Max Conc. mM) |
CAS DataBase Reference | 1392275-56-7 |
FDA UNII | FWF6Q91TZO |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
Tenofovir alafenamide hemifumarate price More Price(16)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-6112 | Tenofoviralafenamidehemifumarate 99.79% | 1392275-56-7 | 5mg | $50 | 2021-12-16 | Buy |
ChemScene | CS-6112 | Tenofoviralafenamidehemifumarate 99.79% | 1392275-56-7 | 10mg | $70 | 2021-12-16 | Buy |
ChemScene | CS-6112 | Tenofoviralafenamidehemifumarate 99.79% | 1392275-56-7 | 50mg | $140 | 2021-12-16 | Buy |
ChemScene | CS-6112 | Tenofoviralafenamidehemifumarate 99.79% | 1392275-56-7 | 100mg | $190 | 2021-12-16 | Buy |
AK Scientific | V9722 | Tenofoviralafenamidehemifumarate | 1392275-56-7 | 5g | $338 | 2021-12-16 | Buy |
Tenofovir alafenamide hemifumarate Chemical Properties,Uses,Production
Description
Tenofovir alafenamide hemifumarate is an investigational oral prodrug of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.
Chemical Properties
White to almost White crystal or crystalline powder.
Originator
Gilead Sciences
Uses
Tenofovir alafenamide hemifumarate is a newer, more effective prodrug used in combination with FTC that has recently been approved for the prevention of HIV transmission through the rectum. It is used to treat chronic hepatitis B virus (HBV) infection in adults with compensated liver disease.
Definition
ChEBI: A fumarate salt prepared from tenofovir alafenamide by reaction of one molecule of fumaric acid for every two molecules of tenofovir alafenamide. A prodrug for tenofovir, it is used in combination therapy for the treatment of HIV-1 infection.
Clinical Use
Tenofovir alafenamide hemifumarate is useful in the treatment and/or prophylaxis of one or more viral infections in man or animals, including infections caused by DNA viruses. RNA viruses, herpesviruses (e.g., CMV, HSV 1, HSV 2, VZV), retroviruses, hepadnaviruses (e.g., HBV), papillomavirus, hantavirus, adenoviruses and HIV. Like tenofovir disoproxil, tenofovir alafenamide is another prodrug form of tenofovir, and can be used in the treatment and/or prophylaxis of the same conditions.
Side effects
Check with your doctor immediately if any of the following side effects occur:
Abdominal or stomach discomfort,bloody urine,dark urine,decreased appetite,decreased frequency or amount of urine,troubled breathing,cough,headache,back pain.
Synthesis
Under a nitrogen atmosphere, 200 g of isopropanol, 9 g of fumaric acid, and 50 g of TAF-3 were sequentially added to a 2 L reaction flask. Turn on the stirring, control the temperature at 40 ~ 50 °C, stir and dissolve, filter while hot, collect the mother liquor. Transfer the mother liquor to a 2L reaction bottle, start stirring, control the temperature at 40 ~ 50 °C, stir and dissolve, slowly reduce the temperature to 0 ~ 5 ° C, cooling time 2 ~ 3 hours, heat stirring for 10 hours. Filtration, drying at 60-65 ° C for 12 to 16 hours, to obtain 37.5 g of Tenofovir Alafenamide Fumarate finished product, white powder, yield 75.0%.
Drug interactions
Some products that may interact with this drug are: adefovir, orlistat, other drugs that may harm the kidneys (including aminoglycosides such as amikacin/gentamicin).
Advantages
One major advantage of the hemifumarate form of tenofovir alafenamide over the monofumarate form is its exceptional capability to purge GS-7339 (i.e., 9-[(R)-2-[[(R)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine, which is the major diastereomeric impurity in the active pharmaceutical ingredient. Thus, the hemifumarate form of tenofovir alafenamide can be more readily and easily separated from impurities than the monofumarate form. Other major advantages of tenofovir alafenamide hemifumarate over the monofumarate form include improved thermodynamic and chemical stability (including long-term storage stability), superior process reproducibility, superior drug product content uniformity, and a higher melting point.
Tenofovir alafenamide hemifumarate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Zison Pharmaceutical (Shandong) Co., Ltd. | +86-0086-531-88259693 +86-18660188356 | maguanglei@zisonpharm.com | China | 53 | 58 |
ENBRIDGE PHARMTECH CO., LTD. | +8613812269233 | tinayang@enbridgepharm.com | China | 303 | 58 |
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd. | +8615065888978 | admin@hsnordpharma.com | China | 92 | 58 |
AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 900 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 | CHINA | 115 | 55 |
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- Sep 5,2022
View Lastest Price from Tenofovir alafenamide hemifumarate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-28 | Tenofovir alafenamide hemifumarate
1392275-56-7
|
US $1050.00-1000.00 / kilograms | 10kilograms | 99% | 100ton | Hebei Dangtong Import and export Co LTD | ||
2024-04-25 | Tenofovir Alafenamide Fumarate
1392275-56-7
|
US $0.00 / kg | 1kg | 99% | 1000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd | ||
2024-04-24 | Tenofovir Alafenamide Fumarate
1392275-56-7
|
US $0.00 / kg | 1kg | 99% | 1000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd |
- Tenofovir alafenamide hemifumarate
1392275-56-7
- US $1050.00-1000.00 / kilograms
- 99%
- Hebei Dangtong Import and export Co LTD
- Tenofovir Alafenamide Fumarate
1392275-56-7
- US $0.00 / kg
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
- Tenofovir Alafenamide Fumarate
1392275-56-7
- US $0.00 / kg
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
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