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PD-L1 inhibitor 1

PD-L1 inhibitor 1 structure

CAS No.: 1675203-84-5

Chemical Name:: PD-L1 inhibitor 1

Synonyms: BMS-202;CS-2416;PD1 inhibitor 2;PD 1 inhibitor 2;PD-1 inhibitor 2;PD-L1 inhibitor 2;PD-L1 inhibitor 1;PD1-PDL1 inhibitor 2;PD-1/PD-L1 inhibitor 2(BMS-202);BMS202 (PD-1/PD-L1 inhibitor 2)

CBNumber:: CB13043328

Molecular Formula:: C25H29N3O3

Molecular Weight:: 419.52

MDL Number:: MFCD29905455

MOL File:: 1675203-84-5.mol

Last updated:2023-06-08 09:02:36

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PD-L1 inhibitor 1 Properties

Boiling point	611.4±55.0 °C(Predicted)
Density	1.133±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
pka	16.06±0.46(Predicted)
form	solid
color	White
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
FDA UNII	KDA2HUE7KP

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

NFPA 704

	0
2		0

PD-L1 inhibitor 1 price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	19132	PD-1/PD-L1 Inhibitor 2 ≥98%	1675203-84-5	1mg	$44	2024-03-01	Buy
Cayman Chemical	19132	PD-1/PD-L1 Inhibitor 2 ≥98%	1675203-84-5	5mg	$172	2024-03-01	Buy
Cayman Chemical	19132	PD-1/PD-L1 Inhibitor 2 ≥98%	1675203-84-5	10mg	$321	2024-03-01	Buy
Cayman Chemical	19132	PD-1/PD-L1 Inhibitor 2 ≥98%	1675203-84-5	25mg	$576	2024-03-01	Buy
TRC	B695175	BMS-202	1675203-84-5	10mg	$310	2021-12-16	Buy

Product number	Packaging	Price	Buy
19132	1mg	$44	Buy
19132	5mg	$172	Buy
19132	10mg	$321	Buy
19132	25mg	$576	Buy
B695175	10mg	$310	Buy

PD-L1 inhibitor 1 Chemical Properties,Uses,Production

Description

The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis. PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC₅₀ value of 18 nM.

Uses

BMS-202 is a Novel inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface.

References

1) Zak?et al.?(2016),?Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1);?Oncotarget?7?30323 2) Guzik?et al.?(2017),?Small-molecule inhibitors of the programmed cell death -1/programmed cell death -ligand 1(PD-1/PD-L1) interaction via transiently induced protein states and dimerization of PD-L1;?J. Med. Chem.?60?5857

PD-L1 inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

PD-L1 inhibitor 1 Suppliers

Global( 92)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10297	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
RR Scientific LLC	+86-13917743231	sales@rrscientific.com	United States	878	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
career henan chemical co	58
Fuxin Pharmaceutical	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
RR Scientific LLC	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58

View Lastest Price from PD-L1 inhibitor 1 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-10	PD-L1 inhibitor 1 1675203-84-5	US $5.50 / KG	1KG	98%min	1kg,10kg,100kg	Career Henan Chemical Co

PD-L1 inhibitor 1
1675203-84-5
US $5.50 / KG
98%min
Career Henan Chemical Co

PD-L1 inhibitor 1 Spectrum

PD-L1 inhibitor 1(1675203-84-5)¹HNMR

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1of3

PD-L1 inhibitor 1 PD1-PDL1 inhibitor 2 N-[2-[[[2-Methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]acetamide BMS-202 Acetamide, N-[2-[[[2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]- PD 1 inhibitor 2 PD1 inhibitor 2 PD-1 inhibitor 2 PD-L1 inhibitor 2 PD-L1 INHIBITOR 2;PD-1 INHIBITOR 2;PD1 INHIBITOR 2;PD 1 INHIBITOR 2;BMS 202;BMS202 PD-1/PD-L1 inhibitor 2(BMS-202) CS-2416 N-{2-[({2-methoxy-6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amino]ethyl}acetamide PD1 INHIBITOR 2;PD 1 INHIBITOR 2;BMS202;BMS 202 BMS202 (PD-1/PD-L1 inhibitor 2) N-(2-(((2-Methoxy-6-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)pyridin-3-yl)methyl)amino)ethyl)acetamide 1675203-84-5