COELENTERAZINE H
- CAS No.
- 50909-86-9
- Chemical Name:
- COELENTERAZINE H
- Synonyms
- COEL;CLZ-H;CLZN-H;ENTERAZINE H;Colenterazine H;COELENTERAZINE H;H-coelenterazine;Renilla Luciferin;LUCIFERIN (RENILLA);2-DEOXYCOELENTERAZINE
- CBNumber:
- CB1304820
- Molecular Formula:
- C26H21N3O2
- Molecular Weight:
- 407.46
- MDL Number:
- MFCD00798394
- MOL File:
- 50909-86-9.mol
| Melting point | >200℃ |
|---|---|
| Boiling point | 593.5±60.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in methanol, ethanol |
| pka | 10.50±0.30(Predicted) |
| form | solid |
| color | Yellow |
| λmax | 437nm |
| Stability | Stable for 1 year from ate of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month. |
| Biological Applications | Calcium indicator; assaying luminescent enzyme; measuring luciferase activity; as a substrate for luciferase; screening HIV-1 protease inhibitors; bioluminescence resonance energy transfer (BRET) detection system |
| FDA UNII | W6HKC9Y0YK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
COELENTERAZINE H price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C3230 | Coelenterazine h solid | 50909-86-9 | 50μg | $203 | 2024-03-01 | Buy |
| Cayman Chemical | 16894 | Coelenterazine h ≥95% | 50909-86-9 | 500μg | $183 | 2024-03-01 | Buy |
| Cayman Chemical | 16894 | Coelenterazine h ≥95% | 50909-86-9 | 1mg | $345 | 2024-03-01 | Buy |
| TRC | C636025 | Coelenterazine h | 50909-86-9 | 1mg | $285 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0007260 | COELENTERAZINE H 95.00% | 50909-86-9 | 5MG | $496.66 | 2021-12-16 | Buy |
COELENTERAZINE H Chemical Properties,Uses,Production
Description
Coelenterazine-h (50909-86-9) may be used as a substrate in gene reporter assays, live cell assays, and biochemical assays (ELISA, BRET etc). Renilla luciferase catalyzes coelenterazine oxidation by oxygen to produce light. Coelenterazine-h produces 10-fold higher light output than native coelenterazine. Coelenterazine-h also undergoes autoluminescence, which is enhanced by superoxide anion and peroxynitrite in cells.
Uses
Coelenterazine h, is a derivative of Coelenterazine (C636000), and iis more sensitive to Ca2+ than is the native complex, thus providing a valuable tool for measuring small changes in Ca2+ concentrations.
Definition
ChEBI: Renilla luciferin is a member of phenols and an imidazopyrazine. It has a role as a luciferin. It derives from a hydride of an imidazo[1,2-a]pyrazine.
General Description
Coelenterazine is an imidazopyrazinone derivative. It is a substrate for bioluminescence in many luminous marine organisms.
Biochem/physiol Actions
10 times higher luminescence intensity than native coelenterazine.
References
1) Shimomura?et al. (1989),?Semi-synthetic aequorins with improved sensitivity to Ca2+ ions; Biochem. J.,?261?913 2) Nakajima-Shimada?et al.?(1991),?Monitoring of intracellular calcium in Saccharomyces cerevisiae with an apoaequorin cDNA expression system; Proc. Natl. Acad. Sci. USA,?88?6878 3) Inouye?et al. (1992),?Monitoring gene expression in Chinese hamster ovary cells using secreted apoaequorin; Anal. Biochem.,?201?114
COELENTERAZINE H Preparation Products And Raw materials
Raw materials
Preparation Products
COELENTERAZINE H Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Deyang Sino Biotech. Co., LTD | 19182167371 19182167371 | service@synlord.com | China | 93 | 58 |
| Beijing Ouhe Technology Co., Ltd | 010-82967028 13552068683 | 2355560935@qq.com | China | 12426 | 60 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12990 | 57 | |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 4548 | 62 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4647 | 58 |
| Nanjing Asian Chemical Co., Ltd. | +86 (25) 82263158 | China | 262 | 60 | |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
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