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DIENESTROL

DIENESTROL
DIENESTROL structure
CAS No.
84-17-3
Chemical Name:
DIENESTROL
Synonyms
DV;Agaldog;Restrol;Retalon;Dinovex;Estroral;Oestrora;Sexadien;Teserene;para-Dien
CBNumber:
CB1312612
Molecular Formula:
C18H18O2
Formula Weight:
266.33
MOL File:
84-17-3.mol

DIENESTROL Properties

Melting point:
229 °C
Boiling point:
349.54°C (rough estimate)
Density 
1.184 g/cm3
refractive index 
1.4800 (estimate)
storage temp. 
2-8°C
form 
neat
pka
9.21±0.15(Predicted)
Water Solubility 
3mg/L(37 ºC)
Merck 
3104
BRN 
2053694
CAS DataBase Reference
84-17-3
EWG's Food Scores
1
FDA UNII
RRW32X4U1F
EPA Substance Registry System
Dienestrol (84-17-3)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H350-H361
Precautionary statements  P201-P280-P308+P313-P202-P405-P501
Hazard Codes  Xn,T
Risk Statements  40-48-62-45
Safety Statements  22-24/25-45-36/37-53
WGK Germany  3
RTECS  SL0580000

DIENESTROL price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1192003 Dienestrol United States Pharmacopeia (USP) Reference Standard 84-17-3 0 $0 2019-12-02 Buy
Sigma-Aldrich D1200000 Dienestrol European Pharmacopoeia (EP) Reference Standard 84-17-3 d1200000 $190 2020-08-18 Buy
Sigma-Aldrich D1200000 Dienestrol European Pharmacopoeia (EP) Reference Standard $190 2021-03-22 Buy
TCI Chemical D0449 Dienestrol >96.0%(GC) 84-17-3 1g $128 2021-03-22 Buy
TCI Chemical D0449 Dienestrol >96.0%(GC) 84-17-3 100mg $20 2021-03-22 Buy

DIENESTROL Chemical Properties,Uses,Production

Chemical Properties

Colorless, needles or powder; odorless. Soluble in alcohol; practically insoluble in water; sensitive to light.

Originator

Synestrol,Schering,US,1947

Uses

Medicine (estrogenic hormone).

Definition

ChEBI: An olefinic compound that is hexa-2,4-diene substituted by 4-hydroxyphenyl groups at positions 3 and 4 respectively.

Manufacturing Process

Preparation of γ,δ-Bis-(4-Hydroxylphenyl)-Hexane-γ,δ-Diol: A sodium amalgam is prepared containing 6 grams of sodium and 400 grams of mercury. The amalgam is covered with a solution of 20 grams of 4-hydroxypropiophenone in a mixture of 30 ml of 5 N sodium hydroxide solution and 220 ml of water and the mixture is heated to 28°-30°C and stirred gently. The reduction is accompanied by development of heat and the temperature of the solution rises to 34°-35°C, and then falls slowly. After 5 hours the alkaline solution is separated from the mercury and diluted with 3 or 4 times its volume of water, when, in order to form the benzoyl derivatives of the products, the solution is vigorously stirred, while it is being cooled, with 20 ml of benzoyl chloride, the solution being kept at a temperature of 15°-20°C. When the reaction is completed, the benzoyl derivatives are filtered off, washed with water and recrystallized from a mixture of benzene and alcohol, when a product with a melting point of 195°-215°C is obtained.
Preparation of Dienestrol: In order to obtain dienoestrol, 14.6 grams of dry 4,4'-dibenzoate are refluxed with a mixture of 40 ml of acetic anhydride and 40 ml acetylchloride by heating in an oil-bath at about 90°C for 6 hours after which the bath temperature is increased to 120°C and heating continued for a further 18 hours, after which time the evolution of hydrogen chloride practically ceases. The mixture is allowed to cool for several hours and the crystals which separate are filtered off and recrystallized from an alcoholbenzene mixture when the product melts at 210°-222°C. This product is converted into dienoestrol by adding 10.8 grams of it to 100 ml of 10% (w/v) alcoholic potassium hydroxide solution and then refluxing during 1 hour. After dilution with 200 ml of water and filtration from a small amount of insoluble material, dienoestrol is precipitated from the alkaline solution by treatment with carbon dioxide. It is filtered off, washed with water and recrystallized from dilute alcohol after which it melts at 233°-234°C according to US Patent 2,464,203.

brand name

Avc/dienestrol;Crinohermal fem;D.v.;Dienostrol cream;Dienstrogen;Dinol;Dufemine;Foragynol;Frein;Klianyi forte;Klianyl;Neo-oestrogenine;Ortho (cream);Ortho dienestrol cream.

Therapeutic Function

Estrogen

World Health Organization (WHO)

Dienestrol is a stilbene derivative. See WHO comment for diethylstilbestrol. Vaginal forms of dienestrol, which were introduced in 1947, are currently available in over 35 countries for the management of hypoestrogenic vaginal atrophy. (Reference: (WHODI) WHO Drug Information, 77.1, 16, 1977)

Safety Profile

Suspected human carcinogen. Human mutation data reported. Experimental reproductive effects. Used as a drug for the treatment of postmenopausal symptoms. When heated to decomposition it emits acrid smoke and irritating fumes.

DIENESTROL Preparation Products And Raw materials

Raw materials

Preparation Products


DIENESTROL Suppliers

Global( 103)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8875 55
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29865 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9937 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 29997 58
J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 400-660-8290 21-61259100-
86-21-61259102 sh@meryer.com China 40264 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24555 81
Energy Chemical 400-005-6266 021-58432009-
021-58436166 sales8178@energy-chemical.com China 42936 61

View Lastest Price from DIENESTROL manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-06-11 DIENESTROL USP/EP/BP
84-17-3
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
2021-05-26 DIENESTROL
84-17-3
US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
2020-01-03 DIENESTROL
84-17-3
US $1.00 / KG 1KG 95-99% 1ton Career Henan Chemical Co

DIENESTROL Spectrum


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