Nolatrexed dihydrochloride
- CAS No.
- 152946-68-4
- Chemical Name:
- Nolatrexed dihydrochloride
- Synonyms
- AG 337;CS-254;Thymitaq;NOLATREXED HCL;NOLATREXED 2HCL;Nolatrexed (AG-337);Nolatrexed hydrochloride;Nolatrexed 2hydrochloride;AG337;NOLATREXED (AG 337);NOLATREXED DIHYDROCHLORIDE
- CBNumber:
- CB1313745
- Molecular Formula:
- C14H14Cl2N4OS
- Molecular Weight:
- 357.26
- MDL Number:
- MFCD00917041
- MOL File:
- 152946-68-4.mol
- MSDS File:
- SDS
| Melting point | 301-3020C |
|---|---|
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | Methanol, Water |
| form | Solid |
| pka | 4.1; 5.9; 9.8(at 25℃) |
| color | Off-White to Pale Yellow |
| Stability | Hygroscopic |
| CAS DataBase Reference | 152946-68-4(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | AG337; Thymitaq |
| FDA UNII | 1XA69O733O |
| NCI Drug Dictionary | nolatrexed dihydrochloride |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361-H341 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501 |
Nolatrexed dihydrochloride price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29247 | Nolatrexed (hydrochloride) | 152946-68-4 | 10mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 29247 | Nolatrexed (hydrochloride) | 152946-68-4 | 100mg | $765 | 2024-03-01 | Buy |
| Cayman Chemical | 29247 | Nolatrexed (hydrochloride) | 152946-68-4 | 5mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 29247 | Nolatrexed (hydrochloride) | 152946-68-4 | 50mg | $437 | 2024-03-01 | Buy |
| Usbiological | 018433 | Nolatrexed Dihydrochloride | 152946-68-4 | 10mg | $382 | 2021-12-16 | Buy |
Nolatrexed dihydrochloride Chemical Properties,Uses,Production
Chemical Properties
Tan Solid
Uses
Antifolate thymidylate synthase inhibitor. Antineoplastic.
Biological Activity
thymidylate synthase (ts) is a crucial enzyme in the synthesis of 2'-deoxythymidine-5'-monophosphate, an essential precursor for dna biosynthesis. thus, this enzyme is a critical target in cancer chemotherapy. nolatrexed (ag-337) is a non-classical thymidylate synthase inhibitor.
in vitro
nolatrexed was designed using x-ray crystallographic data from the ts molecular modeling and folate binding site. it is a non-classical ts inhibitor in that it lacks a terminal glutamate side chain and is uncharged at physiological ph. nolatrexed does not require a specific transport mechanism to enter into cells and, once within the cell, is not a substrate for the enzyme folyl polyglutamate synthetase [1].
in vivo
when nolatrexed was administered to nude mice bearing bu25tk- tumor xenografts, a time-dependent increase in antitumor activity was observed [1].
IC 50
1.0, 0.81 and 1.0 μm for l1210, ccrf-cem and gc3/m tk- cell lines, respectively
References
[1] hughes an, rafi i, griffin mj, calvert ah, newell dr, calvete ja, johnston a, clendeninn n, boddy av. phase i studies with the nonclassical antifolate nolatrexed dihydrochloride (ag337, thymitaq) administered orally for 5 days. clin cancer res. 1999 jan;5(1):111-8.
[2] rafi i, boddy av, calvete ja, taylor ga, newell dr, bailey np, lind mj, green m, hines j, johnstone a, clendeninn n, calvert ah. preclinical and phase i clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors. j clin oncol. 1998 mar;16(3):1131-41.
Nolatrexed dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Nolatrexed dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuxi Rejoys chemical Technology Co., Ltd. | 0510-86103381 | sales@rejoyschem.com | CHINA | 976 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
View Lastest Price from Nolatrexed dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | Nolatrexed dihydrochloride
152946-68-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-02-01 | Nolatrexed dihydrochloride
152946-68-4
|
US $1.00 / KG | 1KG | 98% | 200kgs | Career Henan Chemical Co |
-
- Nolatrexed dihydrochloride
152946-68-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Nolatrexed dihydrochloride
152946-68-4
- US $1.00 / KG
- 98%
- Career Henan Chemical Co